Microneedle technology- an insight into advancements, latest scholarly and patent data

Dhanvanth Kumar C , Prakash S. Goudanavar , Koteswara Rao GSN , M Pradeep Kumar , Kiran Kumar G B , B. Ramesh , N Raghavendra Naveen
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Abstract

Microneedles (MN) have been used to deliver small molecular weight drugs, nucleotides, DNA, peptides, proteins, and even viruses that have been turned off. Over the past ten years, different kinds of MN have been made using several different production methods. Different kinds of materials have been used to make different shapes of microneedles. Using these MNs, different ways of putting drugs through the skin with microneedles have been tried. After a short introduction to microneedles for transdermal use, this review talks about the different kinds, how they are made, and recent improvements in MN delivery. In a separate part of this review, patents survey on MN using databases such as USPTO (United States Patent and Trademark Office), EPO (European Patent Office), and WIPO (World Intellectual Property Organization), etc. are discussed in detail. We talked about recent improvements to MN-based methods for getting drugs and vaccines to people. Because MN worked so well, there was a lot of interest in taking advantage of the opportunities, as patent data shows. With a current worldwide perspective, the current analysis confirms the overall evolution and unexplored areas of MN research and makes microneedle-based (trans)dermal drug delivery systems for effective therapeutic effects.

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微针技术--洞察先进技术、最新学术和专利数据
微针(MN)已被用于输送小分子量药物、核苷酸、DNA、肽、蛋白质,甚至已被关闭的病毒。在过去的十年中,人们使用几种不同的生产方法制造出了不同种类的微针。不同的材料被用来制造不同形状的微针。利用这些微针,人们尝试了不同的微针穿透皮肤给药方法。在简短介绍了透皮微针之后,本综述将讨论不同种类的微针、微针的制作方法以及最近在微针给药方面的改进。本综述的另一部分详细讨论了利用 USPTO(美国专利商标局)、EPO(欧洲专利局)和 WIPO(世界知识产权组织)等数据库对微针进行的专利调查。我们谈到了最近对基于 MN 的向人们提供药物和疫苗的方法的改进。正如专利数据所显示的那样,由于 MN 效果显著,人们对利用这一机会产生了浓厚的兴趣。从当前全球的角度来看,目前的分析证实了微针研究的整体演变和尚未开发的领域,并使基于微针的(经)皮肤给药系统产生了有效的治疗效果。
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