Intelligent Pharmacy最新文献

英文中文

Role of IOT in healthcare: Applications, security & privacy concerns 物联网在医疗保健中的作用：应用、安全和隐私问题

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.01.003

Employing the Internet of Things (IoT) in healthcare provides many advantages for patient monitoring and analysis of the patient's health with the help of generated data. The basic role of IoT in healthcare is to ease the patient's life by giving them a monitor over their medical condition. The use of IoT in medical devices requires a focus on the end-user. Medical devices such as glucose meters are designed to record the data of the patient and their vital signs. The generated information can be used to enhance decision-making for the physician. The collected information about the patient can be at risk due to certain security issues during the transferring of information can compromise the identity and social life of the patient. This review explores the IoT regarding its structural requirement and its role in various fields with special emphasis on healthcare. The security and privacy issues than can hinder the utilization of IoT at its potential and ways to overcome these issues are being addressed.

在医疗保健领域采用物联网（IoT）可利用生成的数据监测和分析病人的健康状况，具有诸多优势。物联网在医疗保健中的基本作用是通过监控病人的医疗状况来缓解病人的生活。在医疗设备中使用物联网需要关注最终用户。血糖仪等医疗设备旨在记录病人的数据及其生命体征。生成的信息可用于加强医生的决策。由于信息传输过程中的某些安全问题，收集到的病人信息可能会危及病人的身份和社会生活。本综述探讨了物联网的结构要求及其在各个领域的作用，并特别强调了医疗保健领域。安全和隐私问题可能会阻碍物联网发挥其潜力，而克服这些问题的方法也正在探讨之中。

引用次数: 0

Cardioprotective potential of Rosuvastatin against isoproterenol induced cardiac dysfunction and hypertrophy in the experimental model of rodents 在啮齿动物实验模型中，瑞舒伐他汀对异丙肾上腺素诱发的心功能障碍和心肌肥厚具有保护作用

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2023.09.002

Aims

Cardiovascular disease is the primary cause of mortality and morbidity, and its terminal phase is chronic heart failure. The present study aimed to examine the protective impact of rosuvastatin on isoproterenol-induced chronic heart failure and investigate plausible related mechanisms. Rosuvastatin, a drug with multiple pleiotropic properties, has been examined for its cardioprotective effects in heart failure induced by isoproterenol.

Methods

Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure by subcutaneous injection. Simultaneously, rosuvastatin (10 mg/kg) was orally administrated from day 1 to day 14. Protective effects were evaluated by heart grading and gross morphology, hemodynamic parameter, cardiac troponin I, heart mitochondrial enzyme and lysosomal hydrolases and pro inflammatory cytokines levels were analyzed.

Results

Rosuvastatin (10 mg/kg) significantly attenuated isoproterenol-induced hypertrophy, remodeling and dysfunction of the ventricle, reduced the heart mitochondrial enzyme and lysosomal hydrolases and normalized the increased hemodynamic and pro inflammatory cytokines levels.

Conclusions

The study highlights the preventive effects of, rosuvastatin, against heart failure. The results of the research indicate that rosuvastatin has cardioprotective effects on the experimental model, which were supported by several characteristics. However, further research is required to identify the precise molecular mechanisms and signalling pathways of rosuvastatin's impact on heart failure.

目的心血管疾病是导致死亡和发病的主要原因，其终末阶段是慢性心力衰竭。本研究旨在探讨洛伐他汀对异丙肾上腺素诱导的慢性心力衰竭的保护作用，并研究相关的合理机制。罗苏伐他汀是一种具有多种生物效应的药物，其对异搏定诱导的心力衰竭具有保护作用。同时，从第 1 天到第 14 天口服洛伐他汀（10 毫克/千克）。通过对心脏分级和大体形态、血液动力学参数、心肌肌钙蛋白 I、心脏线粒体酶和溶酶体水解酶以及促炎细胞因子水平进行分析，评估其保护作用。结果罗苏伐他汀（10 毫克/千克）明显减轻了异丙肾上腺素诱导的心室肥大、重塑和功能障碍，降低了心脏线粒体酶和溶酶体水解酶，并使增加的血液动力学和促炎细胞因子水平恢复正常。研究结果表明，洛伐他汀对实验模型具有心脏保护作用，并得到了一些特征的支持。然而，要确定罗伐他汀对心力衰竭影响的确切分子机制和信号通路，还需要进一步的研究。

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引用次数: 0

Comprehensive evaluation of PD-1 inhibitors marketed in China based on a Quick Guideline for drug evaluation and selection in Chinese Medical Institutions (second edition) 基于《中国医疗机构药物评价与遴选快速指南》（第二版）对在中国上市的PD-1抑制剂进行综合评价

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.07.006

Long Min , Zhao Yulan , Li Wenrui , Shi Weilin , Chen Wanyi

Objective

To conduct a comprehensive evaluation of PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China, using A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions (Second Edition), and to provide a reference for the selection of and decision-making on clinical drugs in hospitals.

Method

The Sanzhi drug evaluation and selection system was used to evaluate the PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China, according to five characteristics: pharmaceutical characteristics, efficiency, safety, economy, and others.

Results

Based on the above evaluation criteria, the scores of all PD-1 inhibitors were above 61 points. The main difference among the five characteristics were efficiency and economy. The difference between the other characteristics was relatively small. Sintilimab injection had the highest score due to the advantages among characteristics except the other attributes. Nivolumab injection (100 mg/10 mL (10 mg/mL)) had the lowest total score due to its low effectiveness and economy scores.

Conclusion

PD-1 inhibitors are effective therapeutic drugs for immunotherapy in patients with advanced non-small cell lung cancer. Different PD-1 inhibitors have different advantages in clinical treatment. The comprehensive evaluation of PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China through A Quick Guide for Drug Evaluation and Selection of Chinese Medical Institutions (Second Edition) can provide a basis for drug selection and scientific, reasonable, and safe drug use in medical institutions.

目的运用《中国医疗机构药品评价与遴选快速指南（第二版）》对我国上市的治疗晚期非小细胞肺癌的PD-1抑制剂进行综合评价，为医院临床用药的遴选和决策提供参考。方法采用 "三智 "药物评价与遴选系统，按照药物特性、有效率、安全性、经济性和其他五个方面对中国上市的治疗晚期非小细胞肺癌的PD-1抑制剂进行评价。五个特征之间的主要差异在于高效性和经济性。其他特征之间的差异相对较小。除其他特性外，辛替利单抗注射液因其特性优势而得分最高。结论PD-1抑制剂是晚期非小细胞肺癌患者免疫疗法的有效治疗药物。不同的 PD-1 抑制剂在临床治疗中具有不同的优势。通过《中国医疗机构药品评价与遴选快速指南（第二版）》对我国上市的治疗晚期非小细胞肺癌的PD-1抑制剂进行综合评价，可为医疗机构遴选药品和科学、合理、安全用药提供依据。

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引用次数: 0

AI's role in revolutionizing personalized medicine by reshaping pharmacogenomics and drug therapy 通过重塑药物基因组学和药物疗法，人工智能在个性化医疗变革中的作用

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.08.005

Hamed Taherdoost , Alireza Ghofrani

This paper examines the transformative impact of artificial intelligence (AI) on pharmacogenomics, signaling a paradigm shift in personalized medicine. With a focus on enhancing drug response prediction and treatment optimization, AI, particularly machine learning and deep learning algorithms, navigates the complexity of genomic data. By elucidating intricate relationships between genetic factors and drug responses, AI augments the identification of genetic markers and contributes to the development of comprehensive models. The review emphasizes AI's role in guiding treatment decisions, minimizing adverse reactions, and optimizing drug dosages in clinical settings. Ethical considerations, challenges, and future directions are also discussed. This work underscores the synergy of AI and pharmacogenomics, offering a more effective and patient-centric approach to drug therapy, marking a significant advancement in the field of personalized medicine.

本文探讨了人工智能（AI）对药物基因组学的变革性影响，这标志着个性化医疗模式的转变。人工智能，尤其是机器学习和深度学习算法，以加强药物反应预测和治疗优化为重点，在复杂的基因组数据中游刃有余。通过阐明遗传因素与药物反应之间错综复杂的关系，人工智能增强了遗传标记的识别能力，并促进了综合模型的开发。综述强调了人工智能在指导治疗决策、减少不良反应和优化临床用药剂量方面的作用。此外，还讨论了伦理考虑因素、挑战和未来方向。这项工作强调了人工智能和药物基因组学的协同作用，为药物治疗提供了更有效和以患者为中心的方法，标志着个性化医疗领域的重大进展。

引用次数: 0

Removal notice to “Ziziphus mauritiana: An in-depth review of its medicinal attributes and pharmacological activities” [Intell. Pharm. 2 (2024) 274–283] 删除 "Ziziphus mauritiana：关于其药用特性和药理活性的深入研究" [Intell.

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.07.005

Deepak Jha , Pallavi Hangargekar , Md Akbar , Ashish Singh Parihar , Saurabh Kashyap , Amol Joshi , Md Azizur Rahman

引用次数: 0

A systematic review on the effectiveness of Zingiber officinale in reducing dental caries 关于辣根在减少龋齿方面功效的系统综述

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.08.001

Raghu Dhanapal , Subramani Parasuraman , Mohammed Zahedul Islam Nizami , Galvin Sim Siang Lin , Jogikalmat Krithikadatta

According to the Global Burden of Disease Study and the World Health Organization, dental caries is one of the most prevalent oral diseases globally. It is well known that dental caries are associated with cariogenic bacteria and their biofilm. Many preventive strategies and therapeutic compounds have been proposed for decades. Among them, various plant-based phytochemical compounds have been investigated against cariogenic bacteria. In this review, we plan to show the effectiveness of Zingiber officinale to reduce dental caries. Z. officinale in ginger is a bioactive spice compound that shows antimicrobial activity. Therefore, it is reasonable to consider the antimicrobials and biofilm inhibition properties of bioactive Z. officinale to rationalize its potential in reducing dental caries. While the literature highlights the general antimicrobial properties of Z. officinale, this review focuses on Z. officinale’s capability against cariogenic microbes and their biofilms. Reported results of minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC), and biofilm inhibition (glucans and adhesion) were systematically reviewed. Common search engines like PubMed, Science Direct, and the Web of Science database are used to retrieve data using the keywords “Zingiber officinale” and “dental caries”. Out of 122 resulting reports, 11 of them were included in this review. It can be concluded that Z. officinale effect against cariogenic bacteria varies depending on microbial and analytical factors. However, translational advanced studies have not yet been conducted to verify its clinical application.

根据全球疾病负担研究和世界卫生组织的数据，龋齿是全球最普遍的口腔疾病之一。众所周知，龋齿与致龋细菌及其生物膜有关。几十年来，人们提出了许多预防策略和治疗化合物。其中，针对致龋细菌的各种植物性植物化学物质已被研究。在这篇综述中，我们计划展示姜科植物 Zingiber officinale 在减少龋齿方面的功效。生姜中的 Z. officinale 是一种生物活性香料化合物，具有抗菌活性。因此，我们有理由考虑生物活性姜辣素的抗菌和生物膜抑制特性，以合理解释其在减少龋齿方面的潜力。虽然文献强调了欧当归的一般抗菌特性，但本综述侧重于欧当归对致龋微生物及其生物膜的抑制能力。我们系统地回顾了最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和生物膜抑制（葡聚糖和粘附）的报告结果。使用 PubMed、Science Direct 和 Web of Science 数据库等常用搜索引擎，以 "细辛 "和 "龋齿 "为关键词检索数据。在检索到的 122 篇报告中，有 11 篇被纳入本综述。可以得出的结论是，欧当归对致癌细菌的作用因微生物和分析因素而异。然而，尚未开展转化性高级研究来验证其临床应用。

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引用次数: 0

Sea buckthorn: A potential dietary supplement with multifaceted therapeutic activities 沙棘：具有多方面治疗作用的潜在膳食补充剂

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2023.12.003

Sea buckthorn (Hippophae rhamnoides L.) is a plant with various nutritional and medicinal properties. It contains vitamins, carotenoids, polyphenols, fatty acids, and phytosterols, which have antioxidant, anticancer, anti-hyperlipidemic, anti-obesity, anti-inflammatory, antimicrobial, antiviral, dermatological, neuroprotective, and hepatoprotective effects. Sea buckthorn can be used as a functional food or a dietary supplement for the prevention and treatment of chronic diseases. This review summarizes the phytochemistry, health benefits, and food applications of sea buckthorn, and highlights the potential and challenges for its further development and utilization. Sea buckthorn not only has greatmedicinal and therapeutic potential, but also is a promising economic plant. The potential of seabuckthorn in the human food industry has attracted the research interest of researchers and pro- ducers. The present review mainly summarizes the phytochemistry, nutrients, health benefits, andfood applications of sea buckthorn. Overall, sea buckthorn is a dietary source of bioactive ingredi- ents with the potential to be developed into functional foods or dietary supplements for the pre- vention and treatment of certain chronic diseases, which deserves further research.

沙棘（Hippophae rhamnoides L.）是一种具有多种营养和药用价值的植物。它含有维生素、类胡萝卜素、多酚、脂肪酸和植物甾醇，具有抗氧化、抗癌、抗高血脂、抗肥胖、抗炎、抗菌、抗病毒、皮肤病、神经保护和肝脏保护作用。沙棘可用作预防和治疗慢性疾病的功能性食品或膳食补充剂。本综述总结了沙棘的植物化学、健康益处和食品应用，并强调了进一步开发和利用沙棘的潜力和挑战。沙棘不仅具有巨大的药用和治疗潜力，也是一种前景广阔的经济植物。沙棘在人类食品工业中的潜力吸引了研究人员和生产商的研究兴趣。本综述主要概述了沙棘的植物化学、营养成分、保健功效和食品应用。总体而言，沙棘是一种生物活性成分的膳食来源，具有开发成功能性食品或膳食补充剂以预防和治疗某些慢性疾病的潜力，值得进一步研究。

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引用次数: 0

Artificial intelligence in anti-dengue drug development 人工智能在抗登革热药物开发中的应用

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.01.006

Dengue fever is a mosquito-borne illness that affects millions of people worldwide. Artificial intelligence (AI) is being employed in the battle against it. AI is being used to analyse dengue immune repertoires, which may yield hitherto unheard-of insights into the complexities of dengue adaptive immunity, help in the development of novel treatments, and influence the creation of vaccines. This AI-driven strategy may contribute to the creation of dengue fever therapies that are more potent.

登革热是一种由蚊子传播的疾病，影响着全球数百万人。人工智能（AI）正被用于防治登革热。人工智能正被用于分析登革热免疫复合物，这可能会产生迄今为止闻所未闻的洞察力，揭示登革热适应性免疫的复杂性，帮助开发新型治疗方法，并影响疫苗的制造。这种人工智能驱动的战略可能有助于开发出更有效的登革热疗法。

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A comprehensive review on the chemical composition and pharmacological activities of ACACIA ARABICA 阿拉伯金合欢化学成分和药理活性综述

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2024.01.008

Since the dawn of time, people have used herbal medications to both prevent and treat a variety of illnesses. Numerous illnesses, including diabetes, skin conditions, and most seriously cancer, have been claimed to be successfully treated by Acacia Arabica. According to Indian traditional medicine, the fresh sections of Acacia Arabica have beneficial nutritional properties as well as astringent, demulcent, aphrodisiac, anthelmintic, antibacterial, and antidiarrheal properties. The ethnobotanical and therapeutic benefits of Acacia Arabica are briefly reviewed in this article along with information about the plants. This is an attempt to gather and record data regarding many facets of Acacia Arabica and its prospective applications. Before using Acacia Arabica's therapeutic potential, more research is required.

自古以来，人们就使用草药来预防和治疗各种疾病。许多疾病，包括糖尿病、皮肤病，以及最严重的癌症，都声称阿拉伯相思树可以成功治疗。根据印度传统医学，阿拉伯相思树的新鲜部分具有有益的营养特性，以及收敛、镇静、壮阳、驱虫、抗菌和止泻特性。本文简要回顾了阿拉伯相思树的人种植物学和治疗功效，以及有关该植物的信息。本文试图收集和记录有关阿拉伯相思树的许多方面及其应用前景的数据。在利用阿拉伯相思树的治疗潜力之前，需要进行更多的研究。

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Mimusops elengi: A comprehensive review Mimusops elengi 的药理、植物化学和治疗功效

Intelligent Pharmacy

Pub Date : 2024-10-01 DOI: 10.1016/j.ipha.2023.11.007

Mimusops elengi, a widely distributed tree species in tropical regions, has been used for centuries in traditional medicine due to its numerous therapeutic properties. In this study, we conducted a comprehensive analysis of the phytocompounds present in various parts of Mimusops elengi, including leaves, bark, and flowers using advanced analytical techniques. The objective was to identify and quantify the bioactive compounds responsible for the plant's medicinal attributes. Our findings revealed a diverse range of phytochemicals in Mimusops elengi. The analysis detected various classes of compounds, including alkaloids, flavonoids, tannins, phenolic compounds, terpenoids and glycosides. Notably, the leaves contained a significant concentration of alkaloids, particularly elengioside, which has demonstrated potential anti-inflammatory and analgesic properties. Additionally, the flowers were rich in flavonoids and tannins, such as quercetin and catechin, known for their antioxidant and anti-cancer activities. Furthermore, the bark of Mimusops elengi exhibited the presence of terpenoids, including lupeol and betulinic acid, which have been associated with anti-inflammatory and antiviral properties. These compounds may contribute to the plant's traditional use for treating various ailments, including skin disorders and respiratory issues. This review provides valuable insights into the phytochemical composition of Mimusops elengi, shedding light on its potential therapeutic applications. Mimusops elengi holds promise as a valuable source of natural compounds with health-promoting benefits.

Mimusops elengi 是一种广泛分布于热带地区的树种，由于其具有多种治疗特性，几个世纪以来一直被用于传统医药中。在这项研究中，我们利用先进的分析技术对 Mimusops elengi 不同部位（包括叶、树皮和花）中的植物化合物进行了全面分析。目的是鉴定和量化导致该植物药用特性的生物活性化合物。我们的发现揭示了 Mimusops elengi 中多种多样的植物化学物质。分析发现了多种化合物，包括生物碱、类黄酮、单宁、酚类化合物、萜类化合物和苷类化合物。值得注意的是，叶片中含有大量生物碱，尤其是elengioside，它具有潜在的抗炎和镇痛特性。此外，花含有丰富的类黄酮和鞣质，如槲皮素和儿茶素，具有抗氧化和抗癌活性。此外，Mimusops elengi 树皮中还含有萜类化合物，包括羽扇豆醇和白桦脂酸，这些化合物具有消炎和抗病毒作用。这些化合物可能有助于该植物在传统上用于治疗各种疾病，包括皮肤病和呼吸道疾病。这篇综述提供了有关 Mimusops elengi 植物化学成分的宝贵见解，揭示了其潜在的治疗用途。Mimusops elengi有望成为具有促进健康功效的天然化合物的宝贵来源。

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