Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan

IF 2.9 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterological Surgery Pub Date : 2023-09-14 DOI:10.1002/ags3.12740

Hiroyasu Kagawa, Yusuke Kinugasa, Tomohiro Yamaguchi, Masayuki Ohue, Kazushige Kawai, Junichiro Hiro, Seiichi Shinji, Hiroaki Nozawa, Yasumitsu Hirano, Koji Komori, Yasumasa Takii, Takeshi Suto, Shunsuke Tsukamoto, Yoshito Akagi, Heita Ozawa, Yuji Toiyama, Kazuhito Minami, Tomoharu Shimizu, Kay Uehara, Kazuhiro Sakamoto, Keita Mori, Kenichi Sugihara, Yoichi Ajioka

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Abstract

Aim

The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics.

Methods

In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors.

Results

The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [P < 0.01] and noncurative resection vs nonresection [P < 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (P < 0.01), bilateral ovarian metastasis (P = 0.01), peritoneal metastasis (P < 0.01), pulmonary metastasis (P = 0.04), liver metastasis (P < 0.01), and remnant of ovarian metastasis (P < 0.01) were statistically significantly different.

Conclusion

The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.

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结直肠癌卵巢转移灶切除术的影响及临床病理分析：日本多中心回顾性研究

目的本研究旨在明确结直肠癌卵巢转移灶切除术的意义，并确定其临床病理特征。方法在这项多中心回顾性研究中，我们评估了 2000 年至 2014 年期间从日本 20 个中心获得的结直肠癌卵巢转移患者的数据。我们研究了切除术对卵巢转移患者预后的影响，并探讨了预后因素。结果研究纳入了296例卵巢转移患者。单发卵巢转移患者的3年总生存率为68.6%。在该队列的所有病例中，治愈性切除、非治愈性切除和非切除后的 3 年总生存率分别为 65.9%、31.8% 和 6.1%（治愈性切除 vs 非治愈性切除 [P < 0.01] 和非治愈性切除 vs 非切除 [P < 0.01]）。在预后因素的多变量分析中，卵巢转移灶的肿瘤大小（P <0.01）、双侧卵巢转移灶（P = 0.01）、腹膜转移灶（P <0.01）、肺转移灶（P = 0.04）、肝转移灶（P <0.01）和卵巢转移灶残余（P <0.01）在统计学上有显著差异。结论与 IV 期结直肠癌相比，单发卵巢转移灶根治性切除术后的预后相对较好。卵巢转移灶切除，不仅是根治性切除，还包括非根治性切除，都能带来生存获益。大的卵巢转移灶、双侧卵巢转移灶、卵巢外转移灶和残余卵巢转移灶是预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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