Annals of Gastroenterological Surgery最新文献

{"title":"Message From the New Editor-In-Chief: Advancing AGSurg Into a Leading International Surgical Journal","authors":"Ken Shirabe","doi":"10.1002/ags3.70151","DOIUrl":"https://doi.org/10.1002/ags3.70151","url":null,"abstract":"<p>Trends in the Impact Factor of <i>Annals of Gastroenterological Surgery (Ag Surg)</i>. <i>AGSurg</i> achieved an impressive first impact factor of 5.164 in 2021. Although the impact factor temporarily declined to 2.7, it has since recovered, reaching 3.3 last year.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"4-5"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1002/ags3.70154","DOIUrl":"https://doi.org/10.1002/ags3.70154","url":null,"abstract":"&lt;p&gt;The publication of invaluable papers in &lt;i&gt;Annals of Gastroenterological Surgery&lt;/i&gt; depends on the prompt, careful review of submitted manuscripts. We would like to thank the following experts for reviewing manuscripts submitted between December 1, 2024 and November 30, 2025.&lt;/p&gt;&lt;p&gt;Abe, Yuta&lt;/p&gt;&lt;p&gt;Aizawa, Masaki&lt;/p&gt;&lt;p&gt;Ajiki, Tetsuo&lt;/p&gt;&lt;p&gt;Akagi, Tomonori&lt;/p&gt;&lt;p&gt;Akamatsu, Nobuhisa&lt;/p&gt;&lt;p&gt;Akita, Hirofumi&lt;/p&gt;&lt;p&gt;Akiyama, Shintaro&lt;/p&gt;&lt;p&gt;Akiyoshi, Takashi&lt;/p&gt;&lt;p&gt;Ando, Koji&lt;/p&gt;&lt;p&gt;Aoki, Takeshi&lt;/p&gt;&lt;p&gt;Aoki, Taku&lt;/p&gt;&lt;p&gt;Aoyagi, Yasuko&lt;/p&gt;&lt;p&gt;Aoyama, Toru&lt;/p&gt;&lt;p&gt;Araki, Kenichiro&lt;/p&gt;&lt;p&gt;Arigami, Takaaki&lt;/p&gt;&lt;p&gt;Arima, Kota&lt;/p&gt;&lt;p&gt;Asai, Koji&lt;/p&gt;&lt;p&gt;Asano, Toshimichi&lt;/p&gt;&lt;p&gt;Baba, Kenji&lt;/p&gt;&lt;p&gt;Bekki, Yuki&lt;/p&gt;&lt;p&gt;Booka, Eisuke&lt;/p&gt;&lt;p&gt;Daiko, Hiroyuki&lt;/p&gt;&lt;p&gt;Ebata, Tomoki&lt;/p&gt;&lt;p&gt;Eguchi, Hidetoshi&lt;/p&gt;&lt;p&gt;Endo, Shungo&lt;/p&gt;&lt;p&gt;Eo, Wankyu&lt;/p&gt;&lt;p&gt;Etoh, Tsuyoshi&lt;/p&gt;&lt;p&gt;Fujio, Atsushi&lt;/p&gt;&lt;p&gt;Fujita, Fumihiko&lt;/p&gt;&lt;p&gt;Fujita, Takeo&lt;/p&gt;&lt;p&gt;Fujiyoshi, Kenji&lt;/p&gt;&lt;p&gt;Fukami, Yasuyuki&lt;/p&gt;&lt;p&gt;Fukui, Yudai&lt;/p&gt;&lt;p&gt;Fukushima, Ryoji&lt;/p&gt;&lt;p&gt;Furuhata, Tomohisa&lt;/p&gt;&lt;p&gt;Furukawa, Kenei&lt;/p&gt;&lt;p&gt;Fuse, Masahiro&lt;/p&gt;&lt;p&gt;Ganeko, Riki&lt;/p&gt;&lt;p&gt;Gohda, Yoshimasa&lt;/p&gt;&lt;p&gt;Goto, Toru&lt;/p&gt;&lt;p&gt;Hagi, Takaomi&lt;/p&gt;&lt;p&gt;Hamabe, Atsushi&lt;/p&gt;&lt;p&gt;Hamada, Madoka&lt;/p&gt;&lt;p&gt;Hanaoka, Marie&lt;/p&gt;&lt;p&gt;Harada, Kazuto&lt;/p&gt;&lt;p&gt;Harimoto, Norifumi&lt;/p&gt;&lt;p&gt;Haruki, Koichiro&lt;/p&gt;&lt;p&gt;Hasegawa, Kiyoshi&lt;/p&gt;&lt;p&gt;Hasegawa, Suguru&lt;/p&gt;&lt;p&gt;Hasegawa, Yasushi&lt;/p&gt;&lt;p&gt;Hashimoto, Daisuke&lt;/p&gt;&lt;p&gt;Hashimoto, Masashi&lt;/p&gt;&lt;p&gt;Hatano, Etsuro&lt;/p&gt;&lt;p&gt;Hayama, Tamuro&lt;/p&gt;&lt;p&gt;Hayami, Shinya&lt;/p&gt;&lt;p&gt;Hayano, Koichi&lt;/p&gt;&lt;p&gt;Hayashi, Hiromitsu&lt;/p&gt;&lt;p&gt;Hayata, Keiji&lt;/p&gt;&lt;p&gt;Hibi, Taizo&lt;/p&gt;&lt;p&gt;Hida, Koya&lt;/p&gt;&lt;p&gt;Hidaka, Masaaki&lt;/p&gt;&lt;p&gt;Hirano, Satoshi&lt;/p&gt;&lt;p&gt;Hirano, Yasumitsu&lt;/p&gt;&lt;p&gt;Hirashita, Teijiro&lt;/p&gt;&lt;p&gt;Hisaka, Toru&lt;/p&gt;&lt;p&gt;Hiyoshi, Yukiharu&lt;/p&gt;&lt;p&gt;Honda, Goro&lt;/p&gt;&lt;p&gt;Honda, Michitaka&lt;/p&gt;&lt;p&gt;Hosoda, Kei&lt;/p&gt;&lt;p&gt;Hu, Qingjiang&lt;/p&gt;&lt;p&gt;Ichikawa, Nobuki&lt;/p&gt;&lt;p&gt;Igaki, Takahiro&lt;/p&gt;&lt;p&gt;Ikenaga, Naoki&lt;/p&gt;&lt;p&gt;Ikeuchi, Hiroki&lt;/p&gt;&lt;p&gt;Ikoma, Hisashi&lt;/p&gt;&lt;p&gt;Imai, Katsunori&lt;/p&gt;&lt;p&gt;Inaki, Noriyuki&lt;/p&gt;&lt;p&gt;Inoue, Mikihiro&lt;/p&gt;&lt;p&gt;Inoue, Yosuke&lt;/p&gt;&lt;p&gt;Irino, Tomoyuki&lt;/p&gt;&lt;p&gt;Ishido, Keinosuke&lt;/p&gt;&lt;p&gt;Ishiyama, Yasuhiro&lt;/p&gt;&lt;p&gt;Ishizawa, Takeaki&lt;/p&gt;&lt;p&gt;Ishizuka, Mitsuru&lt;/p&gt;&lt;p&gt;Ito, Sono&lt;/p&gt;&lt;p&gt;Ito, Takashi&lt;/p&gt;&lt;p&gt;Itoh, Shinji&lt;/p&gt;&lt;p&gt;Iwashita, Yoshiaki&lt;/p&gt;&lt;p&gt;Jiang, Weizhong&lt;/p&gt;&lt;p&gt;Kagawa, Hiroyasu&lt;/p&gt;&lt;p&gt;Kagawa, Yoshinori&lt;/p&gt;&lt;p&gt;Kaibori, Masaki&lt;/p&gt;&lt;p&gt;Kaido, Toshimi&lt;/p&gt;&lt;p&gt;Kajiwara, Yoshiki&lt;/p&gt;&lt;p&gt;Kakisaka, Tatsuhiko&lt;/p&gt;&lt;p&gt;Kakiuchi, Nobuyuki&lt;/p&gt;&lt;p&gt;Kaku, Keizo&lt;/p&gt;&lt;p&gt;Kanaji, Shingo&lt;/p&gt;&lt;p&gt;Kanemitsu, Yukihide&lt;/p&gt;&lt;p&gt;Kanetaka, Kengo&lt;/p&gt;&lt;p&gt;Kasai, Shunsuke&lt;/p&gt;&lt;p&gt;Kato, Yutaro&lt;/p&gt;&lt;p&gt;Kawaguchi, Yoshihiko&lt;/p&gt;&lt;p&gt;Kawai, Kazushige&lt;/p&gt;&lt;p&gt;Kawai, Manabu&lt;/p&gt;&lt;p&gt;Kawaida, Hiromichi&lt;/p&gt;&lt;p&gt;Kawamura, Junichiro&lt;/p&gt;&lt;p&gt;Kawamura, Mikio&lt;/p&gt;&lt;p&gt;Kawanaka, Hirofumi&lt;/p&gt;&lt;p&gt;Kawazoe, Tetsuro&lt;/p&gt;&lt;p&gt;Kikuchi, Hirotoshi&lt;/p&gt;&lt;p&gt;Kimura, Yasutoshi&lt;/p&gt;&lt;p&gt;Kimura, Yutaka&lt;/p&gt;&lt;p&gt;Kinoshita, Takahiro&lt;/p&gt;&lt;p&gt;Kishi, Yoji&lt;/p&gt;&lt;p&gt;Kishino, Takayoshi&lt;/p&gt;&lt;p&gt;Kitago, Minoru&lt;/p&gt;&lt;p&gt;Kitahata, Yuji&lt;/p&gt;&lt;p&gt;Kitami, Chie&lt;/p&gt;&lt;p&gt;Kitano, Shoichi&lt;/p&gt;&lt;p&gt;Kobayashi, Hirotoshi&lt;/p&gt;&lt;p&gt;Kobayashi, Shogo&lt;/p&gt;&lt;p&gt;Kobayashi, Tsuyoshi&lt;/p&gt;&lt;p&gt;Koike, Yuhki&lt;/p&gt;&lt;p&gt;Komatsu, Shoh","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"288-290"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpectedly High Incidence of Immune-Related Adverse Events in Gastric Cancer Patients Who Received Conversion Surgery After Nivolumab-Including Chemotherapy","authors":"Masashi Nishino,&nbsp;Takaki Yoshikawa,&nbsp;Hirokazu Shoji,&nbsp;Yuki Takenaka,&nbsp;Maho Takuwa,&nbsp;Yurina Fujisaki,&nbsp;Rei Ogawa,&nbsp;Takeyuki Wada,&nbsp;Tsutomu Hayashi,&nbsp;Yukinori Yamagata,&nbsp;Nobuyoshi Hiraoka,&nbsp;Yasuyuki Seto","doi":"10.1002/ags3.70103","DOIUrl":"https://doi.org/10.1002/ags3.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nivolumab-including chemotherapy (nivo-CTX) for stage IV gastric cancer (GC) may increase the chance of conversion surgery but risk of immune-related adverse events (irAEs) during perioperative period remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We examined irAEs in 36 patients with marginally resectable GC who received nivo-CTX followed by surgery between November 2021 and March 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Marginally resectable factors were para-aortic lymph node in 23, liver in 3, esophageal intramural metastasis in 2, mediastinal lymph node in 1, peribiliary lymph node in 1, P1b in 2, Bulky N in 5, and T4b in 1. IrAE was observed in 12 patients (33.3%). Among 12 patients, irAE was detected during chemotherapy in 6 patients (50%), after chemotherapy to admission to surgery in 2 (16.7%), and after surgery in 4 (33.3%). Grade 2 irAE was found in 6 patients (16.7%); rash in 6 and thyroiditis in 2, grade 3 was in 3 (8.3%); adrenal insufficiency in 1, hepatitis in 1, and pituitary insufficiency in 1, grade 4 was in 3 (8.3%); type 1 diabetes mellitus in 2, pemphigus in 1, and encephalitis in 1. Grade 3 or 4 irAE was found in 6 patients (16.7%). Among the patients who had irAE, grade 3 or 4 was detected in 2 of 6 during chemotherapy (33.3%) but was in 3 of 4 (75%) after surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>IrAE was frequently observed not only during chemotherapy but also during perioperative period. Surgeons must pay special attention to unfamiliar irAE events during perioperative period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"6-14"},"PeriodicalIF":3.3,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Prophylactic Administration of Sulbactam/Ampicillin Versus Cefmetazole for Prevention of Perineal Wound Infection Following Abdominoperineal Resection for Rectal Cancer: A Multicenter Randomized Controlled Trial","authors":"Akitoshi Nankaku,&nbsp;Shunsuke Kasai,&nbsp;Akio Shiomi,&nbsp;Taiki Masuda,&nbsp;Hiroyuki Hazama,&nbsp;Noriko Iwata,&nbsp;Shunichiro Kato,&nbsp;Shinichi Yamauchi,&nbsp;Hiroyuki Sato,&nbsp;Akihiro Hirakawa,&nbsp;Hiroyasu Kagawa,&nbsp;Masanori Tokunaga,&nbsp;Yusuke Kinugasa","doi":"10.1002/ags3.70118","DOIUrl":"https://doi.org/10.1002/ags3.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Perineal wound infection (PWI) is a critical complication unique to abdominoperineal resection (APR) that requires preventive interventions. This study compared the efficacy of a 4-day regimen of sulbactam/ampicillin (SBT/ABPC) with that of a 1-day regimen of cefmetazole (CMZ) for preventing PWI after APR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty patients who underwent APR for rectal cancer were enrolled in this multicenter, open-label, randomized controlled trial. The primary outcome was the incidence of PWI, and secondary outcomes included the incidence of surgical site infections (SSI), other complications, and length of postoperative hospital stay. Based on an assumed PWI incidence of 46% for CMZ and 14% for SBT/ABPC, a sample size of 40 participants per group was required to achieve a 90% power at a two-sided 10% significance level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 80 randomized patients, 76 were analyzed in the SBT/ABPC (<i>n</i> = 39) and CMZ (<i>n</i> = 37) groups. The incidence of PWI (10.3% vs. 24.3%, respectively; <i>p</i> = 0.096) was significantly lower in the SBT/ABPC group than in the CMZ group, based on a planned two-sided significance level of 10%. SSI, other complications, including antibiotic-related adverse events, and length of postoperative hospital stay, were not significantly different between the two groups. SBT/ABPC demonstrated broader bacterial coverage than CMZ in the PWI treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 4-day SBT/ABPC regimen significantly reduced the incidence of PWI after APR compared to the 1-day CMZ regimen. This simple approach to antibiotic selection may be beneficial for preventing PWI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"15-24"},"PeriodicalIF":3.3,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Pancreaticojejunostomy Reconstruction Following Pancreaticoduodenectomy for Patients With Concomitant Chronic Pancreatitis: How I Do It","authors":"Hideaki Sato,&nbsp;Masaharu Ishida,&nbsp;Naoki Rikiyama,&nbsp;Masamichi Mizuma,&nbsp;Michiaki Unno","doi":"10.1002/ags3.70098","DOIUrl":"https://doi.org/10.1002/ags3.70098","url":null,"abstract":"<p>Surgical management of pancreatic head lesions complicated by chronic pancreatitis (CP) presents significant challenges, particularly in ensuring effective pancreatic duct drainage after resection. This report describes the detailed technique and key considerations for longitudinal pancreaticojejunostomy (LPJ) as a reconstructive method following pancreaticoduodenectomy (PD) in patients with CP. This approach aims to achieve wide-area drainage of the remnant pancreatic duct through a side-to-side anastomosis between the extensively opened pancreatic duct and jejunum. Conceptually derived from conventional drainage procedures such as the Frey and Partington procedures, this technique is particularly beneficial when significant ductal dilatation persists distal to the resection margin. Critical steps for successful LPJ include meticulous exposure of the pancreatic parenchyma, an adequate longitudinal incision of the main pancreatic duct, and precise anastomotic technique. We have successfully applied this procedure in three male patients (median age 68 years, range: 48–77), including one with CP complicated by duodenal bleeding and two with pancreatic head region malignancies complicated with CP. All patients had favorable postoperative outcomes with no clinically relevant postoperative pancreatic fistula (Grade B or C). Long-term follow-up showed significant symptom improvement without medication, and pancreatic function were relatively well preserved. Our preliminary experience suggests that LPJ provides safe and effective drainage of the pancreas following PD in patients with CP-complicated pancreatic head pathology and may represent a valuable reconstructive option, particularly in cases with marked pancreatic duct dilatation.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"281-286"},"PeriodicalIF":3.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘A Multicenter Randomized Controlled Trial Evaluating the Effect of the Use of an Anti-Adhesion Barrier for Diverting Ileostomy on the Multidimensional Workload in Minimally Invasive Surgery for Rectal Cancer (YCOG 2005: The ADOBARRIER Study)’","authors":"","doi":"10.1002/ags3.70102","DOIUrl":"https://doi.org/10.1002/ags3.70102","url":null,"abstract":"<p>E. Ota, J. Watanabe, Y. Suwa, M, et al., “A multicenter randomized controlled trial evaluating the effect of the use of an anti-adhesion barrier for diverting ileostomy on the multidimensional workload in minimally invasive surgery for rectal cancer (YCOG 2005: The ADOBARRIER study),” <i>Annals of Gastroenterological Surgery</i> 9, no. 5 (2025): 971–979. https://doi/full/10.1002/ags3.70009.</p><p>Errors have been identified in Tables 1 and 4 of the published article.</p><p>In Table 1:</p><p>The value for ‘Sex, Female’, column ‘AdSpray™ arm (<i>n</i> = 61)’ should be ‘23 (37.7%)’ instead of ‘38 (37.7%)’.</p><p>The value for ‘PS, 1’, column ‘Control arm (<i>n =</i> 60)’ should be ‘3 (5%)’ instead of ‘3 (5.9%)’.</p><p>In Table 4:</p><p>The value for ‘Blood loss, mL’, column ‘AdSpray™ arm (<i>n</i> = 61)’ should be ‘0 (0–5)’ instead of ‘5 (0–5)’.</p><p>The value for ‘Postoperative complications, Yes’, column ‘AdSpray™ arm (<i>n</i> = 61)’ should be ‘5 (8.2%)’ instead of ‘56 (8.2%)’.</p><p>We apologize for these errors.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Serum Tumor Markers in Esophageal and Gastric Cancers: A Systematic Literature Review","authors":"Yasunori Matsumoto,&nbsp;Takeshi Toyozumi,&nbsp;Hideaki Shimada","doi":"10.1002/ags3.70095","DOIUrl":"https://doi.org/10.1002/ags3.70095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Serum tumor markers are helpful for diagnosis, monitoring treatment outcomes, and prognosis. However, their clinical utility for esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) remains unclear. This study aimed to comprehensively evaluate recent studies on serum tumor markers in ESCC and GC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review and meta-analysis of studies published between January 2010 and March 2025 using PubMed. Overall, 84 and 468 articles on ESCC and GC were extracted, respectively. The sensitivity, specificity, positive predictive value, and summary receiver operating characteristic curves were calculated and evaluated using a systematic review and meta-analysis. Prognostic values were assessed using the hazard ratio based on univariate and multivariate analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In ESCC, squamous cell carcinoma antigen (SCC-Ag) exhibited the highest sensitivity (38.7%) and positive predictive value (85.2%); moreover, it was the only independent prognostic factor across multiple articles. Carcinoembryonic antigen (CEA) and cytokeratin 19 fragment had low sensitivity and predictive value, whereas serum p53 antibody demonstrated moderate prognostic relevance. In GC, CEA and CA125 had the highest sensitivity (37.2%) and positive predictive value (72.2%), respectively, and CA125 and CA72-4 were associated with peritoneal dissemination. CEA and CA125 levels were independent prognostic markers of GC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SCC-Ag is a key marker for ESCC diagnosis and prognosis. CEA and CA125 are valuable markers for GC prognosis, whereas CA125 and CA72-4 help detect peritoneal dissemination. Further research integrating the molecular characteristics of each tumor marker is warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"54-66"},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Survey of the Surgical Treatment for Hiatal Hernia in Japan","authors":"Soji Ozawa,&nbsp;Nobuo Omura,&nbsp;Kazuo Koyanagi,&nbsp;Junya Oguma,&nbsp;Akihito Kazuno,&nbsp;Yuko Kitagawa,&nbsp;Yoshihiro Kakeji,&nbsp;Yasushi Toh,&nbsp;Hisahiro Matsubara","doi":"10.1002/ags3.70079","DOIUrl":"https://doi.org/10.1002/ags3.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to clarify patient background characteristics, preoperative findings, surgical factors, and postoperative outcomes according to hernia type in patients who underwent surgery for hiatal hernia in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective, questionnaire-based clinical review of patients who underwent surgery between January 2001 and December 2015 at institutions with board-certified esophagologists accredited by the Japan Esophageal Society. Data from 960 cases across 80 institutions in Japan were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 960 cases, data on hernia type were available in 838 and included in the analysis. The distribution was as follows: Type I, 524 cases (63%); Type II, 53 (6%); Type III, 171 (20%); and Type IV, 90 (11%). Compared with Types II–IV, Type I patients were younger, more often male, had longer symptom duration, more heartburn, fewer comorbidities, and more severe esophagitis. Strictures were rare, and surgery was more often indicated due to refractoriness to medical treatment. Type I cases had higher rates of laparoscopic surgery and Toupet fundoplication, with shorter operative times, fewer complications, and shorter hospital stays. They had lower rates of postoperative dysphagia. Risk factors for postoperative dysphagia included Types II–IV hernia (OR 1.676, <i>p</i> = 0.002), preoperative dysphagia (OR 1.898, <i>p</i> = 0.006), and esophageal strictures (OR 3.102, <i>p</i> = 0.016). Hernia type was not associated with postoperative recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with Type I hernia differed from those with Types II–IV in background characteristics, preoperative findings, surgical factors, and postoperative outcomes. Given the higher risk of postoperative dysphagia in Types II–IV, careful attention to surgical technique is warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"113-127"},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Clinician-Friendly Online Dynamic Nomogram for Survival Prediction in Colon Cancer Patients","authors":"Mohammad Asghari-Jafarabadi,&nbsp;Simon Wilkins,&nbsp;John Paul Plazzer,&nbsp;Raymond Yap,&nbsp;Paul J. McMurrick","doi":"10.1002/ags3.70091","DOIUrl":"https://doi.org/10.1002/ags3.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study used Bayesian model averaging to develop an online dynamic nomogram for predicting colon cancer survival, showcasing its value in integrating key prognostic factors for clinical use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analysed surgical colon cancer cases from the Cabrini Monash colorectal neoplasia database using Bayesian model averaging to identify survival risk factors. Model performance was validated with data from Alfred Hospital, and dynamic online nomograms were developed using the DynNom R package.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study analysed 2475 colon cancer patients (2010–2021), reporting an overall mortality rate of 6.4 per 100 (95% CI: 5.9–7.1) and post-relapse mortality of 7.0 per 100 (95% CI: 6.4–7.6), with 5-year overall and relapse-free survival probabilities of 0.75 and 0.74, respectively. Bayesian model averaging identified key predictors with posterior inclusion probabilities greater than 0.3, including age, ASA score, stage, chemotherapy, lymph node ratio and cancer side. The model showed strong performance (C-index: 0.84 training, 0.80 validation; AUCs: 0.88–0.91 training, 0.84–0.88 validation), good calibration and clinical utility across thresholds. A dynamic nomogram incorporating these factors was developed using the entire dataset as an accessible online tool to support personalised survival prediction in clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study showcases the robust capabilities of Bayesian model averaging in uncovering key prognostic factors for colon cancer survival. By integrating these predictors into a dynamic online nomogram, it delivers a powerful, clinician-friendly tool that significantly enhances prognostic accuracy and enables personalised, data-driven decision-making in oncology care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"167-177"},"PeriodicalIF":3.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study","authors":"Hiroto Matsui,&nbsp;Naoki Ikenaga,&nbsp;Masafumi Nakamura,&nbsp;Takaaki Tatsuguchi,&nbsp;Shingo Kozono,&nbsp;Hirohisa Okabe,&nbsp;Hiromitsu Hayashi,&nbsp;Tomohiko Adachi,&nbsp;Susumu Eguchi,&nbsp;Kazuaki Hashimoto,&nbsp;Toru Hisaka,&nbsp;Takao Ide,&nbsp;Hirokazu Noshiro,&nbsp;Teijiro Hirashita,&nbsp;Atsushi Miyoshi,&nbsp;Atsushi Nanashima,&nbsp;Masatoshi Kajiwara,&nbsp;Tomoharu Yoshizumi,&nbsp;Yasuhisa Mori,&nbsp;Hiroaki Nagano,&nbsp;Kyushu Study Group of Treatment for Pancreatobilliary Cancer","doi":"10.1002/ags3.70090","DOIUrl":"https://doi.org/10.1002/ags3.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors while also evaluating the effectiveness of neoadjuvant and adjuvant chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed clinicopathological and follow-up data from 1068 PDAC patients who underwent surgical resection at 13 Kyushu Study Group institutions (January 2016–December 2020). Patients were categorized into two groups: without (Group A) or with (Group B) unexpected postoperative noncurative factors. Kaplan–Meier analysis assessed disease-free and overall survival, while univariate and multivariate analyses using the Cox proportional hazards model identified prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Group B (<i>n</i> = 44) had poorer survival than Group A (<i>n</i> = 981) (16.8 vs. 38.6 months; <i>p</i> &lt; 0.001). The noncurative factors were associated with poor disease-free survival (hazard ratio, 1.544; 95% confidence interval, 1.067–2.179; <i>p</i> = 0.022) but not overall survival (hazard ratio, 1.332; 95% confidence interval, 0.910–1.950; <i>p</i> = 0.140). In Group B, patients receiving adjuvant chemotherapy had better disease-free survival (6.8 months vs. 3.4 months; <i>p</i> = 0.092), However, no significant difference was observed in overall survival. Furthermore, patients in Group B who received adjuvant chemotherapy had a worse prognosis compared to both Group A patients who received chemotherapy and those who did not. Preoperative therapy did not improve disease-free survival or overall survival in cases with postoperative noncurative factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cases with noncurative factors had significantly poorer prognoses than those without. In the present study, effective adjuvant chemotherapy for these patients could not be demonstrated. Therefore, thorough preoperative and intraoperative evaluation of noncurative factors is crucial to prevent futile surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"10 1","pages":"251-262"},"PeriodicalIF":3.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}