Predictability of Postprandial Lipidemia by Fasting Values in Young Women

Abstract

For postprandial hyperlipidemia, screening large numbers of subjects by fat-ingestion tests is inconvenient and unrealistic. In the present study, we performed a fat-ingestion test and searched for fasting items to predict postprandial lipidemia. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: In multiple regression analyses, the area under the curve (AUC) and the peak of serum triglyceride (TG) were predictable by fasting (f)-TG itself, the AUC of remnant-like particle-TG (RP-TG) was predictable by f-TG and f-RP-TG, the AUC and the peak of remnant lipoprotein-cholesterol (RLP-C) were predictable by f-RLP-C itself, and those of apolipoprotein B-48 (ApoB48) were predictable by f-ApoB48 itself. The AUC and the peak of TG–RP-TG, an index of non-remnant TG, were predictable by f-TG. Conclusion: Postprandial lipidemia may be predictable by the measurement of the set of fasting serum TG, RLP-C, and ApoB48. For daily medical practice, without performing a fat-ingestion test, the set may provide a useful device for predicting postprandial lipidemia.