Correlation between CD3+, CD4+, CD8+ T Lymphocytes and CRP, IL-6, and PCT in Children with Sepsis and their Value in Disease Assessment

Abstract

Objective: To analyze the relationship between CD3+, CD4+, CD8+ T lymphocyte percentages in peripheral blood lymphocytes and CRP, IL-6, and PCT in children with sepsis and its value in evaluating the severity of the disease. Methods: 91 children diagnosed with sepsis who were hospitalized at the First Affiliated Hospital of Xinxiang Medical College from December 2019 to April 2021 were retrospectively included. Among them, 60 were male (65.9%) and 31 were female (34.1%), aged 3 (1.00, 7.00) years old. Group according to severity of illness. Data were collected within 24 hours of admission. Spearman correlation was used to analyze the relationship between the percentages of CD3+T, CD4+T, CD8+T lymphocytes and CRP, IL-6, and PCT. The non-parametric rank sum test was used to compare differences between mild and severe groups. Logistic regression was used to analyze the relationship between CD3+T, CD4+T, CD8+T lymphocytes and sepsis. Build predictive models to evaluate conditions. Use the Receiver-Operating Curve (ROC) to evaluate the model effect. Results: CD3+T lymphocytes were negatively correlated with PCT, IL-6, and CRP (r=-0.450, P=<0.001; r=-0.378, P=<0.001; r=-0.378). CD8+T lymphocytes were negatively correlated with PCT and CRP (r=-0.215, P=0.041, r=-0.310, P=0.003). There was a negative correlation between the percentage of CD4+T lymphocytes and PCT (r=-0.224, P=0.033). The fever peak, CT3+T (%), CD8+T (%), PCT, CRP, and IL-6 in the mild group were lower than those in the severe group. CD3+T lymphocyte percentage, CRP, and fever peak are risk factors for severe sepsis. Conclusion: The increases in CRP, IL-6, and PCT are negatively correlated with CD3+T, CD8+T, and CD4+T lymphocytes. CD3+T lymphocytes combined with CRP and fever peak can improve the performance of predicting the occurrence of severe sepsis.