The Role of Anti-DFS70 in the Diagnosis of Systemic Autoimmune Rheumatic Diseases

Liudmila Zotova, Victoria Kotova, Zakhar Kuznetsov
{"title":"The Role of Anti-DFS70 in the Diagnosis of Systemic Autoimmune Rheumatic Diseases","authors":"Liudmila Zotova, Victoria Kotova, Zakhar Kuznetsov","doi":"10.3390/biologics3040019","DOIUrl":null,"url":null,"abstract":"The diagnosis of systemic autoimmune rheumatic disease (SARD) or its exclusion is carried out taking into account the results of immunological studies, primarily antinuclear antibodies (ANA) and specific autoantibodies. Often, during ANA analysis via indirect immunofluorescence reaction on cellular and tissue substrates, a dense fine speckled 70 (DFS70) fluorescence pattern is observed. Studies on the diagnostic significance of antibodies to anti-DFS70 allow for optimizing the stepwise diagnosis of SARD. Currently, a two-step strategy for laboratory diagnostic investigation is recommended: in the first step, ANA screening is performed, and in the second step, patients with positive results undergo confirmatory tests to detect specific antibodies against individual nuclear antigens. The detection of anti-DFS70 in ANA-seropositive patients without clinical and/or other specific serological markers characteristic of a particular disease within the SARD group may be considered a negative prognostic marker. Also, in the process of decision making in clinical practice, we should remember that anti-DFS70 can be found in the blood of patients with a different, non-SARD pathology and that most people showing anti-DFS70 are healthy individuals.","PeriodicalId":93526,"journal":{"name":"Biologics (Basel, Switzerland)","volume":"8 6","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biologics (Basel, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/biologics3040019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The diagnosis of systemic autoimmune rheumatic disease (SARD) or its exclusion is carried out taking into account the results of immunological studies, primarily antinuclear antibodies (ANA) and specific autoantibodies. Often, during ANA analysis via indirect immunofluorescence reaction on cellular and tissue substrates, a dense fine speckled 70 (DFS70) fluorescence pattern is observed. Studies on the diagnostic significance of antibodies to anti-DFS70 allow for optimizing the stepwise diagnosis of SARD. Currently, a two-step strategy for laboratory diagnostic investigation is recommended: in the first step, ANA screening is performed, and in the second step, patients with positive results undergo confirmatory tests to detect specific antibodies against individual nuclear antigens. The detection of anti-DFS70 in ANA-seropositive patients without clinical and/or other specific serological markers characteristic of a particular disease within the SARD group may be considered a negative prognostic marker. Also, in the process of decision making in clinical practice, we should remember that anti-DFS70 can be found in the blood of patients with a different, non-SARD pathology and that most people showing anti-DFS70 are healthy individuals.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
抗dfs70在系统性自身免疫性风湿病诊断中的作用
系统性自身免疫性风湿病(SARD)的诊断或排除要考虑免疫学研究的结果,主要是抗核抗体(ANA)和特异性自身抗体。通常,在细胞和组织底物上通过间接免疫荧光反应进行ANA分析时,可以观察到密集的细斑点70 (DFS70)荧光模式。研究抗dfs70抗体的诊断意义,可以优化SARD的逐步诊断。目前,实验室诊断调查建议采取两步策略:第一步,进行ANA筛查,第二步,结果阳性的患者进行确认试验,以检测针对单个核抗原的特异性抗体。在无临床和/或SARD组中特定疾病特征的其他特异性血清学标志物的ana血清阳性患者中检测到抗dfs70可被视为阴性预后标志物。此外,在临床实践决策过程中,我们应该记住,抗dfs70可以在不同的非sard病理患者的血液中发现,并且大多数显示抗dfs70的人是健康个体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The Role of Anti-DFS70 in the Diagnosis of Systemic Autoimmune Rheumatic Diseases Is Metagenomics the Future Routine Diagnosis Tool for Brain Abscesses? About a Case Neoantigens: The Novel Precision Cancer Immunotherapy Dose-Dependency of the Glycemic Response to Polyphenol-Rich Sugarcane Extract (PRSE) Robust Porcine GFR Measurement with Radiotracers and Only Late Blood Samples
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1