Advances in Carotenoid Based Delivery Systems for Alleviating Inflammatory Bowel Disease

IF 5.3 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Reviews International Pub Date : 2023-10-26 DOI:10.1080/87559129.2023.2273928
Yan Zhang, Jiangfeng Song, Hongjuan Wang, Ying Li, Caie Wu
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Abstract

ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, and its etiology remains unclear. Presently, main drugs such as aminosalicylic acid, glucocorticoid, immunosuppressive and biological agents are employed to treat IBD. However, because of the long-term use of medication, it adversely affects other human organs. Therefore, natural bioactive compounds are applied as supplements or alternative drugs to alleviate IBD. As a kind of plant natural compounds with strong antioxidant and anti-inflammatory activities, carotenoids have exhibited potent effects in reducing intestinal inflammation. However, direct oral administration of carotenoids might cause the low specificity of inflammatory sites, which is attributed to its poor aqueous solubility and limited stability. The construction of nutrient delivery system has become an effective, efficient and dependable means. This review summarizes the delivery systems loaded with carotenoids, explores their mechanism and applications in alleviating IBD, and aims to provide corresponding theoretical references for developing novel delivery systems and their practical prospects in IBD.KEYWORDS: Inflammatory bowel diseasecarotenoidsdelivery systemapplication AcknowledgmentsThis work was supported by the project of Natural Science Foundation of Jiangsu Province (Project No. BK20201241) and Independent Innovation Fund Project of Agricultural Science and Technology in Jiangsu Province (Project No. CX (20)3047).Disclosure statementNo potential conflict of interest was reported by the author(s).Author contributionsThe manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.
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基于类胡萝卜素的缓解炎症性肠病输送系统的研究进展
炎症性肠病(IBD)是一种慢性胃肠道炎症性疾病,其病因尚不清楚。目前,治疗IBD的主要药物有氨基水杨酸、糖皮质激素、免疫抑制剂和生物制剂等。然而,由于长期使用药物,它对人体其他器官产生不利影响。因此,天然生物活性化合物被用作缓解IBD的补充剂或替代药物。类胡萝卜素作为一种具有较强抗氧化和抗炎活性的植物天然化合物,在减轻肠道炎症方面表现出了强有力的作用。然而,直接口服类胡萝卜素可能导致炎症部位特异性较低,这是由于其水溶性差和稳定性有限。养分输送系统的建设已成为一种有效、高效、可靠的手段。本文综述了类胡萝卜素负载给药系统的研究进展,探讨了类胡萝卜素在缓解IBD中的作用机制和应用,旨在为开发新型给药系统及其在IBD中的应用前景提供相应的理论参考。关键词:炎症性肠病类胡萝卜素给药系统应用江苏省农业科技自主创新基金项目(项目编号:BK20201241);残雪(20)3047)。披露声明作者未报告潜在的利益冲突。作者的贡献本手稿是由所有作者共同撰写的。所有作者都同意了手稿的最终定稿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food Reviews International
Food Reviews International 工程技术-食品科技
CiteScore
11.50
自引率
1.70%
发文量
127
审稿时长
>24 weeks
期刊介绍: Food Reviews International presents state-of-the-art reviews concerned with food production, processing, acceptability, and nutritional values—examining the relationship of food and nutrition to health, as well as the differing problems affecting both affluent and developing nations. Offering technical solutions to critical global food dilemmas and shortages, Food Reviews International contains articles of interest for: •food scientists and technologists •food and cereal chemists •chemical engineers •agriculturists •microbiologists •toxicologists •nutritionists
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