Effect of Boric Acid on Oxidative Damage in Immunocompetent Organs under Conditions of Potassium Bichromate and Gamma Radiation Exposure

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2730

Marat Iztleuov, Yerbolat Iztleuov, Gulnara Temirova, Dariga Yesmukhanova, Ainur Akhmetova, Assem Temirbayeva, Raushan Medeuova, Almagul Zhumasheva, Arailym Sarishova

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Abstract

The immune system supports antigenic homeostasis in the body and regulates the processes of proliferation and differentiation of cellular components in hemo- and immunopoiesis. Chromium compounds and ionizing radiation lead to the formation of highly reactive free radicals. Sublethal dose of gamma-irradiation is characterized by a 56% decrease in thymus cellularity and a 22% decrease in lymph nodes against the background of a 44% increase in the number of lymphoid cells in the spleen. Under the combined effect of hexavalent chromium and gamma-radiation, a decrease in the number of lymphoid cells is observed. In thymus the cellularity decreases by 70%, in spleen - by 40%, in lymph nodes - by 42% in comparison with control data. Under the influence of boric acid the number of lymphoid cells in thymus significantly increases by 47%, in lymph nodes - by 14% (p<0.05) compared to the data of irradiated animals. Boric acid administration weakens the development of oxidative stress, lipid peroxidation decreases, and the activity of antioxidant defense enzymes in immunocompetent cells is increased.

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硼酸对重铬酸钾和γ辐射照射下免疫功能器官氧化损伤的影响

免疫系统支持体内抗原稳态，并调节造血和免疫生成过程中细胞成分的增殖和分化过程。铬化合物和电离辐射导致高活性自由基的形成。亚致死剂量γ辐照的特点是胸腺细胞减少56%，淋巴结减少22%，而脾脏淋巴样细胞数量增加44%。在六价铬和γ辐射的共同作用下，观察到淋巴样细胞数量减少。与对照数据相比，胸腺细胞减少70%，脾脏减少40%，淋巴结减少42%。在硼酸的影响下，胸腺淋巴样细胞数量比辐照动物显著增加47%，淋巴结淋巴样细胞数量显著增加14% (p < 0.05)。硼酸可减弱氧化应激的发展，降低脂质过氧化反应，提高免疫能力细胞抗氧化防御酶的活性。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.