Phytonutrients as Potential Dietary Supplements to Ameliorate Sarcopenia via the Involvement of Autophagic Pathway

IF 5.3 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Reviews International Pub Date : 2023-11-12 DOI:10.1080/87559129.2023.2274487
Yujie Sun, Qingwei Zheng, Juan Sun, Li Wang, Yan Li
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Abstract

ABSTRACTAlthough sarcopenia has been a serious public health concern worldwide in recent years, its effective prevention and intervention measures are still lacking. The latest research has found that autophagy dysfunction is an essential mechanism in the pathogenesis of sarcopenia. And meanwhile, increasing studies have shown that phytonutrients consumption is positively correlated with the maintenance of skeletal muscle mass and strength, which involves the regulation of the autophagy pathway. However, due to the opposite environmental-dependent effect of autophagy in sarcopenia, targeting autophagy by phytonutrients as the treatment of sarcopenia is sometimes considered controversial. Thus, in this review, based on the illustration of the relationship between autophagy and skeletal muscle and the complex changes of autophagy in sarcopenia, the phytonutrients ameliorating sarcopenia by regulating autophagy are reviewed with emphasis, and the possible underlying mechanisms are systematically summarized. Despite some controversies, most current studies support the idea that maintaining basal and functional autophagy contributes to the treatment of sarcopenia. Several phytonutrients exhibit substantial beneficial effects on sarcopenia by targeting autophagy, with polyphenols (especially catechins and urolithin A) considered to be of potentially effective clinical relevance. Hence, the development of phytonutrients is a promising approach to the treatment of sarcopenia and its complications.KEYWORDS: Skeletal musclesarcopeniaautophagyphytonutrients AcknowledgmentsThis work was supported by the National Natural Science Foundation of China (32071166 and 32072254); the Ministry of Science and Technology of China (2022YFF1100502); the Earmarked Fund for China Agriculture Reasearch System (CARS-08-G19); the “Qing Lan Project” of Jiangsu Province and the Young Elite Scientists Sponsorship Program by CAST (2020QNRC001).Disclosure statementThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Data availability statementNo data was used for the research described in the article.Additional informationFundingThe work was supported by the Ministry of Science and Technology of China [2022YFF1100502]; National Natural Science Foundation of China [32071166]; the Young Elite Scientists Sponsorship Program by CAST [2020QNRC001]; the “Qing Lan Project” of Jiangsu Province; the Earmarked Fund for China Agriculture Reasearch System [CARS-08-G19].
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植物营养素作为潜在的膳食补充剂,通过参与自噬途径改善肌肉减少症
摘要近年来,肌少症已成为世界范围内严重的公共卫生问题,但缺乏有效的预防和干预措施。最新研究发现,自噬功能障碍是肌少症发病的重要机制。同时,越来越多的研究表明,植物营养素的消耗与骨骼肌质量和力量的维持呈正相关,这涉及到自噬途径的调节。然而,由于自噬在肌少症中具有相反的环境依赖作用,因此植物营养素靶向自噬作为肌少症的治疗有时被认为是有争议的。因此,本文在阐述自噬与骨骼肌的关系以及自噬在骨骼肌减少症中的复杂变化的基础上,重点综述了植物营养素通过调节自噬改善骨骼肌减少症的研究进展,并对其可能的机制进行了系统的总结。尽管存在一些争议,但目前大多数研究都支持维持基础和功能性自噬有助于治疗肌少症的观点。几种植物营养素通过靶向自噬对肌肉减少症表现出实质性的有益作用,其中多酚类物质(特别是儿茶素和尿素A)被认为具有潜在的有效临床意义。因此,植物营养素的开发是治疗肌肉减少症及其并发症的一种很有前途的方法。关键词:骨骼肌;骨骼肌减少;自噬;中国科学技术部(2022YFF1100502);中国农业科研体系专项基金(CARS-08-G19);江苏省“青蓝计划”和中国科协青年精英科学家资助计划(2020QNRC001)。披露声明作者声明,他们没有已知的竞争经济利益或个人关系,可能会影响本文所报道的工作。数据可用性声明本文所描述的研究未使用任何数据。本研究由中国科学技术部资助[2022YFF1100502];国家自然科学基金[32071166];中国科协青年精英科学家资助计划[2020QNRC001];江苏省“青兰工程”;中国农业科研体系专项基金[CARS-08-G19]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food Reviews International
Food Reviews International 工程技术-食品科技
CiteScore
11.50
自引率
1.70%
发文量
127
审稿时长
>24 weeks
期刊介绍: Food Reviews International presents state-of-the-art reviews concerned with food production, processing, acceptability, and nutritional values—examining the relationship of food and nutrition to health, as well as the differing problems affecting both affluent and developing nations. Offering technical solutions to critical global food dilemmas and shortages, Food Reviews International contains articles of interest for: •food scientists and technologists •food and cereal chemists •chemical engineers •agriculturists •microbiologists •toxicologists •nutritionists
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