Pharmacotherapy in Cardiovascular Disease with Chronic Kidney Disease Medications: A Comprehensive Literature

Maryam Azhar, Muneeb Zafar, Ali Irtaza, Madiha Asad, Sajal Kim, Manam Walait, Huda Rehman Mir, Salman Walyat
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Abstract

A progressive decrease of renal function is a symptom of chronic kidney disease, commonly known as chronic kidney failure. The body may accumulate hazardous amounts of fluid, electrolytes, and wastes if the patient has advanced chronic kidney disease. There are several causative factors which lead to CKD which include high or low blood pressure, more accumulation of cholesterol, diabetes and many more. According to WHO global health statistics in 2012, 864,226 mortalities (or 15% of all deaths worldwide) were attributed to this illness. CKD was categorized 14th on the index of principal causes of death, having 122 mortalities per 100,000 persons. Most of the causes of deaths were due to sudden cardiac arrests in CKD patients. In this review, we made a list of 10 FDA approved medications which has proven to decrease CKD and fatalities caused by cardiac arrests. SGLT-2 inhibitors have shown promising results in manipulating kidney functions to improve the efficiency of heart.
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心血管疾病与慢性肾脏疾病药物的药物治疗:综合文献
肾功能进行性下降是慢性肾脏疾病的一种症状,通常被称为慢性肾衰竭。如果患者患有晚期慢性肾脏疾病,身体可能会积聚有害数量的液体、电解质和废物。导致慢性肾病的原因有很多,包括高血压或低血压,胆固醇积累过多,糖尿病等等。根据世卫组织2012年全球卫生统计数据,有864 226例死亡(占全世界所有死亡人数的15%)归因于这种疾病。慢性肾病在主要死亡原因指数中排名第14,每10万人中有122人死亡。大多数死亡原因是由于CKD患者的心脏骤停。在这篇综述中,我们列出了10种FDA批准的药物,这些药物已被证明可以减少CKD和心脏骤停引起的死亡。SGLT-2抑制剂在操纵肾脏功能以提高心脏效率方面显示出有希望的结果。
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Pakistan Journal of Medical & Health Sciences
Pakistan Journal of Medical & Health Sciences MEDICINE, GENERAL & INTERNAL-
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期刊介绍: Pakistan Journal of Medical and Health Sciences is an international biomedical journal from Pakistan. We publish materials of interest to the practitioners and scientists in the broad field of medicine. Articles describing original qualitative, quantitative, human/animal clinical or laboratory studies are considered for publication.
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