Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases

IF 0.4 Q4 OTORHINOLARYNGOLOGY Case Reports in Otolaryngology Pub Date : 2023-11-11 DOI:10.1155/2023/4788617
W. F. Julius Scheurleer, Weibel W. Braunius, Bernard M. Tijink, Luuk M. Janssen, Frank A. Pameijer, Gerben E. Breimer, Ernst J. Smid, Remco de Bree, Lot A. Devriese, Johannes A. Rijken
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Abstract

Background. Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition. Methods. Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted. Results. Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease. Conclusion. Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)‐radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.
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鼻窦畸胎瘤的诊断与治疗:附三例报告
背景。摘要鼻窦畸胎瘤是一种罕见的侵袭性恶性肿瘤,几乎只发生在鼻腔、鼻窦或前颅底。组织病理学诊断可能是具有挑战性的,由于异质性的组成。方法。对3例在乌得勒支大学医学中心诊治的鼻窦畸形瘤肉瘤患者进行回顾性分析。结果。患者表现为鼻塞、鼻出血、头痛或行为改变。所有三名患者都有局部晚期疾病,其中一人有淋巴结转移。2例患者行手术后放疗,1例行新辅助化疗后手术。随访时间为3 ~ 32个月。三名患者均因疾病进展而死亡。结论。鼻窦畸胎癌肉瘤的特点是快速、侵袭性的局部扩张。由于转移和局部复发的风险高,预后较差。多模式治疗包括手术,随后(化疗)-放疗,是优化结果的必要条件。新辅助治疗提供了一个有希望的治疗选择。
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来源期刊
Case Reports in Otolaryngology
Case Reports in Otolaryngology OTORHINOLARYNGOLOGY-
自引率
0.00%
发文量
20
审稿时长
13 weeks
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