Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Inflammatory Marker in Preeclampsia: A Scoping Review

Abstract

Background: Preeclampsia (PE) is characterized as pregnancy-related hypertensive disease with unclear pathophysiology but causes tremendous fetomaternal death. Some predisposing factors considered to be responsible are statistical characteristics, hereditary and factors in the environment should purpose local abnormalities in activation of cytogenic elements along with integrins, matrix metalloproteinases, cytokines, and foremost histocompatibility complex molecules mainly responsible for reduced blood supply to placenta and fetus, trophoblastic cellular apoptosis and abnormal placentation. Aim: In the current scoping review (ScR), the detection of PE using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as an inflammatory marker which is easily available at primary health system. Methodology: The subject’s relevant researches were found using an ScR format from database searches in PubMed and Google Scholar. Out of 179 articles 10 fulfilled inclusion criteria which were systematically reviewed and underwent meta-analysis to highlight the knowledge gaps and further additional case–control study done in tertiary care center. Conclusion: Maternal NLR and PLR resulting from whole blood cell count is an easily available and routinely performed test, obtained as cost-benefit biomarkers for the early prediction of hypertensive disorders of pregnancy.