Evaluation of Bioactive Compounds Obtained from Ginkgo Biloba Against Crystal Structure of Myelin Oligodendrocyte Glycoprotein (MOG)

Abstract

Multiple Sclerosis (MS) spreads rapidly across the globe, causing almost 2.8 million cases worldwide. Many drugs and inhibitors, such as dronabinol and nabilone, have been used to treat MS, but there is no effective treatment for MS till now as these medications can cause severe side effects. So, we tested different compounds from Ginkgo biloba to inhibit the symptoms caused by MS as an herbal treatment. We targeted the Crystal structure of Myelin Oligodendrocyte Glycoprotein as it has shown some excellent results in experimental labs. In this article, the binding interactions through the molecular docking model was performed. Further compound's effectiveness through various screening protocols such as the ADME Test, Bioavailability Radar Test, and BOILED-Egg Test has been done. This study found that Amentoflavone and Isoginkgetin have the potential to inhibit the Crystal Structure of Myelin Oligodendrocyte Glycoprotein as they show the least binding energies which are -7.79 kcal/mol and -8.14 kcal/mol. To check the effectiveness of these compounds, Molecular Dynamics Simulations and in-vitro studies can be done to find some possible herbal treatments for Multiple Sclerosis.