Influence of the immunomodulator kargdekhin on cellular and humoral immunity of the holstein-frisian and red-steppe breed of cattle in leptospirosis

Abstract

Regardless of the breed affiliation in cattle with leptospirosis, suppression of neutrophil activity to the ability to digest foreign agents, neutrophil mobilization coefficient and, conversely, an increase in phagocytic number were revealed. Phagocytosis indices in the Red Steppe breed were significantly higher than in the Holstein-Frisian breed. In patients with leptospirosis of the Holstein-Frisian breed, suppression of the activity of acid phosphatase, myeloperoxidase, and the level of lysosomal cationic proteins was revealed. The Red Steppe breed showed a decrease only in the activity of acid phosphatase, relative to clinically healthy animals. After the application of highly effective drugs to sick animals (antibiotic, hepatoprotector, vitamins, trace elements, immunomodulator kargdechin), an increase in phagocytosis processes was found, in addition, cytochemical parameters were restored faster in the Red Steppe breed, which indicated a higher immune status relative to the Holstein-Frisian and breed.