Etiotropic activity of the combined drug «EshriPhage» in vitro

Nikolay V. Pimenov, Alexey I. Laishevtsev
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Abstract

The intensification of the production of livestock and poultry products determines the strengthening of biological control and containment of the morbidity of animals, including birds, as well as the spread of infections that determine sanitary and epizootic distress. Coli-salmonella infection is widespread. By their antibiotic resistance, the microorganisms Escherichia coli and Salmonella spp. they belong to a high and critical priority group, most of the existing antibiotics for which are not active. To implement the tasks facing veterinary science and practice, formed by the global problem of combating epizootics of escherichiosis and salmonellosis, ensuring sanitary well-being, including products, a drug based on bacteriophages «EshriPhage» has been developed. Commission tests of the etiotropic activity of the combined agent «EshriPhage» in vitro in the spot test revealed a high level of epizootically significant isolates of coli-salmonella infection. Data are presented that allow us to recommend the widespread introduction of EshriPhage into practice and the further development of methods of epizootic control over bacterioses using bacteriophages.
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联合用药“EshriPhage”的体外致病因活性
牲畜和家禽产品生产的集约化决定了加强生物控制和控制包括禽类在内的动物的发病率,以及决定卫生和动物流行病困境的感染的传播。大肠杆菌感染很普遍。根据它们的抗生素耐药性,大肠杆菌和沙门氏菌属于高度和关键的优先群体,大多数现有的抗生素对它们没有活性。为了完成兽医科学和实践所面临的任务,这是由对抗埃希菌病和沙门氏菌病的全球问题所形成的,确保卫生福利,包括产品,开发了一种基于噬菌体的药物“EshriPhage”。委员会对联合制剂“EshriPhage”的致病因活性进行了体外现场试验,结果显示大肠沙门氏菌感染的分离株具有很高的动物流行病意义。所提出的数据使我们能够建议将EshriPhage广泛引入实践,并进一步发展使用噬菌体控制细菌的动物流行病方法。
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