Effect of postnatal environmental enrichment on LTP induction in the CA1 area of hippocampus of prenatally traffic noise-stressed female rats

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2023-01-01 DOI:10.3934/neuroscience.2023021
Fatemeh Aghighi, Mahmoud Salami, Sayyed Alireza Talaei
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Abstract

Early-life stress negatively alters mammalian brain programming. Environmental enrichment (EE) has beneficial effects on brain structure and function. This study aimed to evaluate the effects of postnatal environmental enrichment on long-term potentiation (LTP) induction in the hippocampal CA1 area of prenatally stressed female rats. The pregnant Wistar rats were housed in a standard animal room and exposed to traffic noise stress 2 hours/day during the third week of pregnancy. Their offspring either remained intact (ST) or received enrichment (SE) for a month starting from postnatal day 21. The control groups either remained intact (CO) or received enrichment (CE). Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area; then, LTP was induced by high-frequency stimulation. Finally, the serum levels of corticosterone were measured. Our results showed that while the prenatal noise stress decreased the baseline responses of the ST rats when compared to the control rats (P &lt; 0.001), the postnatal EE increased the fEPSPs of both the CE and SE animals when compared to the respective controls. Additionally, high-frequency stimulation (HFS) induced LTP in the fEPSPs of the CO rats (P &lt; 0.001) and failed to induce LTP in the fEPSPs of the ST animals. The enriched condition caused increased potentiation of post-HFS responses in the controls (P &lt; 0.001) and restored the disrupted synaptic plasticity of the CA1 area in the prenatally stressed rats. Likewise, the postnatal EE decreased the elevated serum corticosterone of prenatally stressed offspring (P &lt; 0.001). In conclusion, the postnatal EE restored the stress induced impairment of synaptic plasticity in rats' female offspring.

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产后环境富集对产前交通噪声应激雌性大鼠海马CA1区LTP诱导的影响
& lt; abstract><p>早期生活压力会对哺乳动物的大脑编程产生负面影响。环境富集(EE)对大脑结构和功能有有益的影响。本研究旨在评价出生后环境富集对产前应激雌性大鼠海马CA1区长期增强(LTP)诱导的影响。妊娠Wistar大鼠饲养于标准动物室,在妊娠第三周每天暴露于交通噪声环境2小时。他们的后代要么保持完整(ST),要么接受富集(SE),从出生后第21天开始一个月。对照组要么保持原状(CO),要么接受浓缩(CE)。在CA1区记录基本场兴奋性突触后电位(fepsp);然后用高频刺激诱发LTP。最后,测定血清皮质酮水平。我们的研究结果显示,与对照组相比,产前噪声应激降低了ST大鼠的基线反应(P <0.001),与各自的对照组相比,出生后EE增加了CE和SE动物的fEPSPs。此外,高频刺激(HFS)诱导CO大鼠fEPSPs发生LTP (P <0.001),未能在ST动物的fEPSPs中诱导LTP。富集条件导致对照组hfs后反应增强(P <0.001),并恢复了产前应激大鼠CA1区的突触可塑性。同样,产后EE降低了产前应激子代升高的血清皮质酮(P <0.001)。综上所述,产后情感表达可恢复应激引起的雌性后代突触可塑性损伤。& lt; / abstract>
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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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