Exploring the biological activity of organotin carboxylate complexes with 4-sulfosalicylic acid

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI:10.4314/bcse.v37i6.11

Dhekra Jawad Hashim, Enass J. Waheed, Angham G. Hadi, Sadiq J. Baqir

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Abstract

ABSTRACT. 4-Sulfosalicylic acid (SSA) was used as a ligand to prepare new triphenyltin and dimethyl-tin complexes by condensation with the corresponding organotin chloride salts. The complexes were identified by different techniques, such as infrared spectra (tin and proton), magnetic resonance, and elemental analyses. The 119Sn-NMR was studied to determine the prepared complexes' geometrical shape. Two methods examined the antioxidant activity of (SSA) and prepared complexes; Free radical scavenging activity (DPPH) and CUPRRAC methods. Tri and di-tin complexes gave high percentage inhibition than ligands with both methods due to tin moiety; the triphenyltin carboxylate complex was the best compared with the others. Also, antibacterial activity was assessed by using the agar ditch method against (Escherichia coli) and (Staphylococcus aureus) bacteria. The complexes gave high activity in inhibition than the ligand derived. Also Triphenyltin carboxylate complex showed higher antibacterial activity than the dimethyltin complex against two types of bacteria (Escherichia coli) and (Staphylococcus aureus). KEY WORDS: Antioxidant activity, Antibacterial activity, Sulfosalicylic acid, Tri phenyl tin chloride, Escherichia coli, Staphylococcus aureus bacteria Bull. Chem. Soc. Ethiop. 2023, 37(6), 1435-1442. DOI: https://dx.doi.org/10.4314/bcse.v37i6.11

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探讨羧酸有机锡与4-磺基水杨酸配合物的生物活性

摘要以4-磺基水杨酸(SSA)为配体，与相应的有机氯化锡盐缩合制备了新的三苯基锡和二甲基锡配合物。这些配合物通过红外光谱(锡和质子)、磁共振和元素分析等不同技术进行了鉴定。用119Sn-NMR测定了所制备配合物的几何形状。两种方法检测了(SSA)的抗氧化活性并制备了配合物;自由基清除活性(DPPH)和CUPRRAC方法。由于锡部分的存在，三锡和二锡配合物比两种方法的配体具有更高的抑制率;羧酸三苯基锡配合物效果最好。采用琼脂沟法对大肠杆菌和金黄色葡萄球菌进行抑菌活性测定。该配合物比衍生的配体具有更高的抑制活性。三苯基羧酸锡配合物对大肠杆菌和金黄色葡萄球菌的抑菌活性也高于二甲基锡配合物。关键词:抗氧化活性、抑菌活性、磺基水杨酸、三苯基氯化锡、大肠杆菌、金黄色葡萄球菌;公牛。化学。Soc。中国生物医学工程学报，2017,37(6)，1435-1442。DOI: https://dx.doi.org/10.4314/bcse.v37i6.11

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.