Synthesis, characterization and biocompatibility of glycine modified graphene oxide

Abstract

AbstractGraphene oxide has a great potential for use in medicine for creating systems for targeted drug delivery, as well as for creating diagnostic and theranostics tools. This work is devoted to study of biocompatibility of graphene oxide modified with glycine. The identification of the covalent conjugate was carried out by 13С nuclear magnetic resonance spectroscopy, elemental analysis, X-ray photoelectron spectroscopy, thermogravimetric analysis and infrared spectroscopy. The study of the biocompatibility of the synthesized nanomaterial included the study of hemocompatibility, antioxidant activity, cyto- and genotoxicity, as well as the protective effect with respect to collagen under UV irradiation.Keywords: Graphene oxideglycinehemocompatibilityphotoprotective effectproliferation AcknowledgmentsThe research was performed using the equipment of the Center for optical and laser materials research, Research Centre for X-ray diffraction studies, Magnetic Resonance Research Center, Center for Physical methods of surface investigation, Thermogravimetric and Calorimetric Research Center, Computer Center of SPbU and the Centre for Chemical analysis and materials research of the Research Park of Saint Petersburg State University.Data availability statementThe authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.Disclosure statementThe authors report there are no competing interests to declare.Additional informationFundingThe work was carried out with the financial support of the Ministry of Health of the Russian Federation “Molecular design and creation of drugs based on conjugates of carbon nanostructures, vectors of targeted delivery and cytotoxic agents for inactivation of stem tumor cells and components of the tumor microenvironment,” EGISU:123021300231-8.