New 1, 2, 3-triazole-Furan Scaffold Schiff bases: Design, Synthesis, Characterization and biological studies

Q4 Earth and Planetary Sciences Research Journal of Chemistry and Environment Pub Date : 2023-08-15 DOI:10.25303/2709rjce0107
T.M. Somanatha, G. Krishnaswamy, R. Nayana, J. Nayana, R. Bhavana, G. Shivaraj, S. Sreenivasa, Prakash M. Shet
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引用次数: 0

Abstract

In the present investigation, Schiff bases (SBs) bearing 1, 2, 3-triazole and furan motif were synthesized through condensation reaction via conventional approach (Route-A) and solvent free approach (Route-B). It has been found that route-B is efficient since it is eco friendly with short reaction time and satisfactory yield than route-A. The structure and formation of targeted Schiff bases (SBs) were confirmed by different spectroscopic techniques (1H NMR, 13C NMR and Mass). Finally, in vitro antimicrobial screening result revealed that the synthesised SBs derivatives may act as moderate antimicrobial agents.
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新型1,2,3 -三唑-呋喃席夫碱支架:设计、合成、表征和生物学研究
在本研究中,通过常规方法(路线a)和无溶剂方法(路线b)合成了含有1,2,3 -三唑和呋喃基序的Schiff碱(SBs)。研究发现,b路线比a路线更环保,反应时间短,产率满意,是有效的。利用不同的波谱技术(1H NMR, 13C NMR和Mass)证实了目标席夫碱(SBs)的结构和形成。体外抗菌筛选结果表明,合成的SBs衍生物具有中等抑菌作用。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
195
审稿时长
4-8 weeks
期刊介绍: Information not localized
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