Estimation of Secondary Cancer Risk of Radiosensitive Organs for Leukemia from Head Radiotherapy in Pediatric Patients

Shiva Rahbar Yazdi, Mohammad Hosein Zare, Mohammad Ali Broomand
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 Materials and Methods: In this expository cross-sectional study, from 45 patients who were examined, 16 patients age under 18 years (mean age of 9.6) met the criteria for entering the study in Shahid Ramezanzadeh Hospital in Yazd underwent whole brain radiotherapy (WBRT) using COMPACT accelerator. Measurement was performed using thermoluminescent dosimeters (TLD). After radiation therapy, the secondary cancer risk in these organs was calculated.
 Results: The organ dose mean values in female patients were 1.8±0.1, 1.65±0.61, 1.47±0.04, 0.1±0.03, and 1.58±0.52 cGy in the eye lenses, parotid, thyroid, breast, and region overlying ovaries, respectively and 2.7±0.6, 0.76±0.17, 0.6±0.05, and 0.005±0.002 cGy for eye lens, parotid, thyroid, breast, and testis of male patient, respectively. The ERR and EAR were estimated after 3, 5, 10, 15 and 20 years for eye lens, parotid breast, and ovary/testis for female/male.
 Conclusion: Higher risk values were found for eye lenses and thyroid. The scattered rays decreased by increasing the organ distance from the treatment radiation field.","PeriodicalId":44212,"journal":{"name":"Iranian Journal of Pediatric Hematology and Oncology","volume":"88 1","pages":"0"},"PeriodicalIF":0.4000,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pediatric Hematology and Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijpho.v13i4.13768","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
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Abstract

Background: The scattered radiation from the treatment volume might be more significant for children than for adults because of life expectancy. The present study used biological effects of ionizing radiation (BEIR) VII models to estimate radiation-induced secondary cancer risks in irradiated organs following three-dimensional conformal radiation therapy (3D-CRT) of Acute Lymphocytic Leukemia (ALL) in children. Both excess absolute risk (EAR) and excess relative risk (ERR) models were used to estimate the secondary cancer risks of eye lenses, thyroid, parotid, breast, and region overlying ovaries. Materials and Methods: In this expository cross-sectional study, from 45 patients who were examined, 16 patients age under 18 years (mean age of 9.6) met the criteria for entering the study in Shahid Ramezanzadeh Hospital in Yazd underwent whole brain radiotherapy (WBRT) using COMPACT accelerator. Measurement was performed using thermoluminescent dosimeters (TLD). After radiation therapy, the secondary cancer risk in these organs was calculated. Results: The organ dose mean values in female patients were 1.8±0.1, 1.65±0.61, 1.47±0.04, 0.1±0.03, and 1.58±0.52 cGy in the eye lenses, parotid, thyroid, breast, and region overlying ovaries, respectively and 2.7±0.6, 0.76±0.17, 0.6±0.05, and 0.005±0.002 cGy for eye lens, parotid, thyroid, breast, and testis of male patient, respectively. The ERR and EAR were estimated after 3, 5, 10, 15 and 20 years for eye lens, parotid breast, and ovary/testis for female/male. Conclusion: Higher risk values were found for eye lenses and thyroid. The scattered rays decreased by increasing the organ distance from the treatment radiation field.
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小儿头部放疗对白血病放射敏感器官继发癌风险的评估
背景:由于预期寿命的原因,治疗量对儿童的散射辐射可能比成人更显著。本研究使用电离辐射(BEIR) VII生物学效应模型来评估儿童急性淋巴细胞白血病(ALL)三维适形放射治疗(3D-CRT)后受照射器官中辐射诱导的继发性癌症风险。使用过度绝对风险(EAR)和过度相对风险(ERR)模型来估计眼晶状体、甲状腺、腮腺、乳房和卵巢上覆区域继发性癌症的风险。材料和方法:在这项阐述性横断面研究中,来自亚兹德Shahid Ramezanzadeh医院的45名患者中,有16名年龄在18岁以下(平均年龄9.6岁)符合进入研究标准的患者使用COMPACT加速器接受了全脑放疗(WBRT)。采用热释光剂量计(TLD)进行测量。放射治疗后,计算这些器官继发性癌症的风险。 结果:女性患者晶状体、腮腺、甲状腺、乳房、卵巢上覆区器官剂量平均值分别为1.8±0.1、1.65±0.61、1.47±0.04、0.1±0.03、1.58±0.52 cGy;男性患者晶状体、腮腺、甲状腺、乳房、睾丸器官剂量平均值分别为2.7±0.6、0.76±0.17、0.6±0.05、0.005±0.002 cGy。分别在3、5、10、15和20年后对女性/男性的晶状体、腮腺乳房和卵巢/睾丸进行ERR和EAR评估。 结论:晶状体和甲状腺有较高的危险值。散射射线随器官与治疗辐射场距离的增加而减小。
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来源期刊
CiteScore
0.80
自引率
33.30%
发文量
33
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