The Value IRS-1 rs1801278G > A Polymorphism Testing in Evaluating Infertile Women with Polycystic Ovarian Syndrome: A Case-control Study

IF 0.3 Q4 OBSTETRICS & GYNECOLOGY Current Women s Health Reviews Pub Date : 2023-09-06 DOI:10.2174/1573404820666230906091306
Zeena Raad Helmi, Wassan Nori, Muna Abdul Ghani Zghair
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Abstract

Background: Polycystic ovary syndrome (PCOS) is a leading cause of infertility. Insulin resistance is a key element in pathogenesis. The insulin receptor causes phosphorylation of the insulin receptor substrate (IRS); IRS-1 rs1801278G > A polymorphism variant is the most common genetic variant associated with IR and PCOS. Objective: We aimed to examine the frequency of IRS-1 rs1801278G > A polymorphism variant and test its value in evaluating infertile PCOS women. Methods: A case-control study recruited 140 age and body-mass-matched participants in the university hospital, subdivided according to Rotterdam criteria into PCOS cases (70/140) and healthy controls (70/140). We collected demographic data, ultrasonic [antral follicles and endometrial thickness], hormonal [FSH, LH, AMH, E2], and genetic data by polymerase chain reaction for analysis. Result: Wild GG SNP rs1801278 G was meaningfully higher among controls (58.57%, P<0.0001). Mutant AA SNP rs1801278 was significantly higher in PCOS women (37.14%, P-value =0.0001, an odds ratio of 20.50, 95% CI (9.42-28.63) to develop PCOS. Heterogenous GA gene SNP rs1801278 showed a trend of higher frequency in PCOS patients with 44.29%; OR of 3.91, 95% CI (1.37–7.55); P = 0.422. Upon correlating infertility parameters to SNP rs1801278 G>A polymorphism, statistical differences were found with AFC, LH/FSH ratio, and serum testosterone. As for the AMH, E2, and endometrial thickness, they failed to have a statistical value. Conclusion: The significant correlation of genetic polymorphism to infertility parameters among PCOS women opens a new therapeutic and prognostic avenue that helps gynecologists tailor manganate for a better and safer outcome.
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IRS-1的数值多囊卵巢综合征不孕妇女的多态性检测:一项病例对照研究
背景:多囊卵巢综合征(PCOS)是导致不孕的主要原因。胰岛素抵抗是发病的关键因素。胰岛素受体引起胰岛素受体底物(IRS)的磷酸化;IRS-1 rs1801278G;多态性变异是与IR和PCOS相关的最常见的遗传变异。目的:探讨IRS-1 rs1801278G >多态性变异及其在评价不育性多囊卵巢综合征中的价值。方法:在大学医院招募年龄和体重匹配的140例患者,按鹿特丹标准分为多囊卵巢综合征患者(70/140)和健康对照组(70/140)。我们通过聚合酶链反应收集了人口统计学数据、超声[窦卵泡和子宫内膜厚度]、激素[FSH、LH、AMH、E2]和基因数据进行分析。结果:野生GG SNP rs1801278 G在对照组中显著升高(58.57%,P<0.0001)。突变型AA SNP rs1801278在PCOS女性中显著升高(37.14%,p值=0.0001,优势比为20.50,95% CI(9.42 ~ 28.63))。异质性GA基因SNP rs1801278在PCOS患者中出现频率较高,占44.29%;OR为3.91,95% CI (1.37-7.55);P = 0.422。将不孕参数与SNP rs1801278 G>A多态性相关联,发现与AFC、LH/FSH比值、血清睾酮有统计学差异。AMH、E2、子宫内膜厚度均无统计学意义。结论:多囊卵巢综合征(PCOS)患者遗传多态性与不孕参数的显著相关性为妇科医生定制治疗方案提供了新的治疗和预后途径,以获得更好、更安全的结局。
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来源期刊
Current Women s Health Reviews
Current Women s Health Reviews OBSTETRICS & GYNECOLOGY-
CiteScore
0.70
自引率
25.00%
发文量
67
期刊介绍: Current Women"s Health Reviews publishes frontier reviews on all the latest advances on obstetrics and gynecology. The journal"s aim is to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all clinicians and researchers in the fields of obstetrics and gynecology.
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