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Double-dose Versus Single-dose Methotrexate Therapy in Treatment of Ectopic Pregnancy 治疗宫外孕的双剂量与单剂量甲氨蝶呤疗法
IF 0.3 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2024-07-04 DOI: 10.2174/0115734048286695240627060120
L. Pourali, A. Vatanchi, H. Majd, N. Ghomian, Solaleh Jabarzadeh
Methotrexate (MTX) was traditionally administered using the multi-doseregimen or single-dose protocols to treat ectopic pregnancies. The two-dose regimen was describedas a cross between these two previous protocols aiming to lower side effects than multi-dose with ahigher success rate of single-dose protocols. Hence, this study compared double-dose versus singledosemethotrexate therapy in the treatment of ectopic pregnancy.This prospective cohort study was performed on the women referred to the academichospitals of Mashhad University of Medical Sciences from March 2018 to July 2021 who were diagnosedas having stable tubal ectopic pregnancy and selected for medical treatment with methotrexate.Statistical analysis was performed using the Statistical Package for the Social Sciences(SPSS) software (version 26). P≤0.05 was considered a significant level.A total number of 347 patients were included in this study. About 300 cases were evaluated:240 cases in single-dose and 60 cases in the double-dose group. The Beta Human chorionicgonadotropin (Beta-hCG) declined more than 15% between days 4 and 7 and was significantlyhigher in the double-dose group (P<0.001). Regarding the time from MTX administration until Beta-hCG level <5mIU/mg, this time was significantly shorter in the double-dose group (P=0.045).Considering the side effects, there was no complication in any of the groups. However, tubal rupturewas seen in 17 cases of double-dose and 10 cases in the single-dose group, respectively.The results of the current study showed a higher treatment success rate in double-doseMTX protocol with comparable side effects compared to single-dose MTX protocol for the treatmentof stable tubal ectopic pregnancy.
甲氨蝶呤(MTX)传统上采用多剂量方案或单剂量方案治疗异位妊娠。双剂量方案被描述为这两种方案的交叉,其目的是降低多剂量方案的副作用,同时提高单剂量方案的成功率。这项前瞻性队列研究的对象是 2018 年 3 月至 2021 年 7 月期间转诊至马什哈德医科大学附属医院的妇女,她们被诊断为患有稳定的输卵管异位妊娠,并被选中接受甲氨蝶呤药物治疗,研究采用社会科学统计软件包(SPSS)(26 版)进行统计分析。本研究共纳入 347 例患者。本研究共纳入 347 例患者,对其中约 300 例进行了评估:单剂量组 240 例,双剂量组 60 例。人绒毛膜促性腺激素(Beta-hCG)在第 4 天和第 7 天之间下降超过 15%,双剂量组明显高于单剂量组(P<0.001)。从服用 MTX 到 Beta-hCG 水平<5mIU/mg,双剂量组的时间明显更短(P=0.045)。本研究结果表明,与单剂量 MTX 方案相比,双剂量 MTX 方案治疗稳定期输卵管异位妊娠的成功率更高,且副作用相当。
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引用次数: 0
The Trend of Cesarean Hysterectomy in Hamadan, Iran, between 2009-2022 2009-2022 年间伊朗哈马丹剖腹产子宫切除术的发展趋势
IF 0.4 Q3 Medicine Pub Date : 2024-05-16 DOI: 10.2174/0115734048287230240429171400
N. Radnia, E. Talebi-Ghane, Heydar Tavilani, Maryam Garousian, Neda Alimohammadi, Marzieh Ghorbani
The data indicated that out of 114175 deliveries, there were 60 hysterectomies over 14years with the age range of 20-45 years. The incidence of hysterectomy increased from 0.34/1000during 2009-2015 to 0.71/1000 deliveries in 2015-2022, with an overall incidence of 0.53 per 1000deliveries during 14 years. The results indicated that the mean rate of hysterectomy (0.95% CI) increasedsignificantly by 0.059 yearly, and by adjusting other variables, the history of CS (0.95% CI)and placenta accreta previa significantly increased the hysterectomy mean rate by 0.291 (0.053-0.529) and 0.284 (0.074-0.494), respectively.The mean rate of hysterectomy represented an annual increase, especially during thelast 7 years. In summary, the main reason can be the history of CS that leads to placental disordersand, thus, hysterectomy.
数据显示,在 114175 例分娩中,14 年内有 60 例子宫切除术,年龄范围为 20-45 岁。子宫切除术的发生率从 2009-2015 年的 0.34/1000 例增至 2015-2022 年的 0.71/1000 例,14 年间的总发生率为 0.53/1000 例。结果显示,子宫切除术的平均率(0.95% CI)每年显著增加 0.059,调整其他变量后,CS(0.95% CI)和前置胎盘显著增加子宫切除术的平均率,分别为 0.291(0.053-0.529)和 0.284(0.074-0.494)。总之,主要原因可能是 CS 史导致胎盘功能紊乱,从而导致子宫切除。
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引用次数: 0
Human Papillomavirus Genotype Distribution in a Hospital-basedSingle-Center Study 一项基于医院的单中心研究中的人类乳头瘤病毒基因型分布情况
IF 0.4 Q3 Medicine Pub Date : 2024-05-10 DOI: 10.2174/0115734048280294240429115337
S. Hashemi, Farrokh Modarresi, A. Esmailzadeh, Nazanin Zeinab Sheikhsofla
Cervical cancer is reported as one of the most prevalent malignanciesworldwide in women. There is a substantial connection between cervical diseases and infectionwith Human Papillomavirus (HPV), especially Types 16 and 18 of HPV.This study aimed to assess the HPV genotype distribution to determine its most commontype at a referral hospital in Iran.This cross-sectional study was conducted on 400 women with positive HPV result testswho visited the gynecologic oncology clinic of Baqiyatallah Hospital from 2017-2021.The average age of subjects was 37.46±9.75 years (range=19-74). About 167 (41.8%) ofthe patients were between 25 to 35 years. The analysis showed that 137 (34.2%) patients had onlylow-risk (LR) typing, 129 (32.2%) patients had only high-risk (HR) typing, and 134 (33.5%) patients had both HR and LR typing. The most frequent LR HPV types were HPV 6 (18.5%) and 11(17%), and the most frequent HR HPV types were HPV-16 (14.7%), 52 (8.2%), 18, and 31 (6.5%).This study showed that the most frequent age category in both low- and HR HPVpositive women is the age 25 to 35 years. The second most common HR-HPV subtypes includedHPV-52, not HPV-18, which indicates variations in HR-HPV subtypes in different populations andraces and warrants further research.
据报道,宫颈癌是全球妇女最常见的恶性肿瘤之一。本研究旨在评估伊朗一家转诊医院的 HPV 基因型分布情况,以确定其最常见的类型。本横断面研究的对象是 2017-2021 年期间在 Baqiyatallah 医院妇科肿瘤门诊就诊的 400 名 HPV 检测结果呈阳性的女性。其中约 167 名(41.8%)患者的年龄在 25 岁至 35 岁之间。分析表明,137 例(34.2%)患者只有低危(LR)分型,129 例(32.2%)患者只有高危(HR)分型,134 例(33.5%)患者同时具有高危和 LR 分型。最常见的 LR HPV 类型是 HPV 6(18.5%)和 11(17%),最常见的 HR HPV 类型是 HPV-16(14.7%)、52(8.2%)、18 和 31(6.5%)。其次,最常见的 HR-HPV 亚型包括 HPV-52,而非 HPV-18,这表明不同人群和种族的 HR-HPV 亚型存在差异,值得进一步研究。
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引用次数: 0
Prevention of Anaemia in Pregnancy: A Five-Year Scoping Review 预防妊娠期贫血:五年范围审查
IF 0.4 Q3 Medicine Pub Date : 2024-05-09 DOI: 10.2174/0115734048283699240429110405
Olubukola E. Abiodun-Ojo, Cecilia B. Bello, Laofe O. Ogundipe
Approximately 50% of pregnant women globally suffer from pregnancy-relatedanaemia, which is a serious issue for reproductive health and can lead to a number of complications, including low birth weights, premature deliveries, foetal deformities, and feto-maternalmortality.This study aimed to evaluate the suggested strategies to prevent anaemia in pregnancythrough a 5-year scoping review (November, 2017 to November, 2022).A comprehensive list of keyword combinations linked to anemia prevention in pregnancy and pertinent approaches to inform the search strategy were evaluated. Significantevents, including pregnancy and anemia, were cross-referenced with the frequency and variability of terms across time. Literature from Pubmed (MEDLINE), Google Scholar, PLOS One,and Cochrane database were reviewed.Evidence-based preventative therapy options for iron deficiency anaemia in pregnancyinclude prophylactic iron supplementation, food fortification with iron and folate, and healtheducation. There is a wealth of research on the effects of these therapies on the occurrence ofanaemia during pregnancy. However, these prospects are endangered by several variables, suchas inadequate health facilities, low maternal health literacy, low utilisation of maternal healthcare in developing countries, a dearth of resources for health education, and lack of a government policy that prevents anaemia during pregnancy.If the highlighted challenges are appropriately addressed through the provision ofhealth education material, the effectiveness of anaemia prevention in pregnancy could be sustained.
全球约有 50%的孕妇患有与妊娠相关的贫血症,这对生殖健康而言是一个严重的问题,可导致一系列并发症,包括出生体重不足、早产、胎儿畸形和胎儿-产妇死亡。本研究旨在通过一项为期 5 年(2017 年 11 月至 2022 年 11 月)的范围界定综述,对预防妊娠期贫血的建议策略进行评估。包括妊娠和贫血在内的重要内容与不同时期的词频和变异性进行了交叉比对。对来自 Pubmed (MEDLINE)、Google Scholar、PLOS One 和 Cochrane 数据库的文献进行了综述。妊娠期缺铁性贫血的循证预防疗法包括预防性铁补充剂、铁和叶酸食品添加剂以及健康教育。关于这些疗法对孕期贫血发生的影响,已有大量研究。如果能通过提供健康教育材料来适当应对上述挑战,那么预防妊娠期贫血的效果就能持续下去。
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引用次数: 0
Breast Cancer and Women’s Health Physicians: Implications for NewApproaches to Diagnosis and Treatment 乳腺癌与女性健康医生:诊断和治疗新方法的意义
IF 0.4 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.2174/157340482003240213150542
John Yeh
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引用次数: 0
Is Stress Urinary Incontinence Symptom Determined by the Severity ofAnterior Compartment Prolapse? 压力性尿失禁症状是由前尿道脱垂的严重程度决定的吗?
IF 0.4 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.2174/1573404820666230407114456
F. Moegni, Adri Dwi Anggayana, Seno Adjie, S. Hakim, T. Priyatini
Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) would developsimultaneously because of the same etiopathogenesis of pelvic floor weakness. Some studieshave said the association between SUI symptoms may be determined by the degree of anterior compartmentprolapse. Then some incidences of occult SUI could also mask the symptom of SUI in thesevere stage of POP.A total of 32 women diagnosed with POP and SUI from the urogynecology clinic were includedin a cross-sectional study between 2019 and 2020. The degree of anterior compartment prolapsewas measured using the POP-Q system (Ba point), while SUI's severity was measured using a 1-hour pad test in grams. The correlation between the severity of SUI (with the occurrence of occultSUI) and the anterior compartment prolapse was analyzed.No correlation was observed between the degree of anterior compartment prolapse and SUIdegree (r = 0.240, p = 0.182). Occult SUI was found in only 5/24 (20.8%) grade III and IV anteriorcompartment prolapse cases.SUI symptom was not determined by the severity of anterior compartment prolapse. Theprevalence of occult SUI in severe POP was also low.
压力性尿失禁(SUI)和盆腔器官脱垂(POP)会同时发生,因为它们的病因相同,都是盆底肌无力。一些研究表明,SUI 症状之间的关联可能取决于前房脱垂的程度。一项横断面研究共纳入了 32 名在 2019 年至 2020 年期间从泌尿妇科门诊诊断出患有 POP 和 SUI 的女性。研究使用 POP-Q 系统(Ba 点)测量前房脱垂的程度,而 SUI 的严重程度则使用以克为单位的 1 小时垫测试来测量。分析了 SUI 严重程度(包括隐性 SUI 的发生)与前室脱垂之间的相关性,未发现前室脱垂程度与 SUI 程度之间存在相关性(r = 0.240,p = 0.182)。仅在 5/24 例(20.8%)III 级和 IV 级前房脱垂病例中发现了隐匿性 SUI。在重度 POP 中,隐匿性 SUI 的发生率也很低。
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引用次数: 0
A Complex Case: Solid Unilateral Ovarian Mucinous CarcinomaMasquerading as Leiomyosarcoma in Postmenopausal Women 一个复杂的病例:绝经后妇女单侧卵巢实性粘液腺癌伪装成子宫肌瘤
IF 0.4 Q3 Medicine Pub Date : 2024-03-20 DOI: 10.2174/0115734048299563240318061151
Naina Kumar, I. Pradeep, M. Mangla, Annapurna Srirambhatla
Ovarian cancers are the third most common gynecological and 8th mostcommon cancer in women, associated with high mortality rates globally.A 60-year-old postmenopausal woman presented to the Gynecological outpatientdepartment with complaints of pain in the abdomen for 2-3 months and loss of appetite withweight loss for 1-2 months. She was diagnosed as a case of uterine leiomyosarcoma or left adnexalmass on ultrasound and MRI. Intra-operatively, she was diagnosed with a unilateral left ovarian malignantmass, predominantly solid in consistency with metastasis to the left fallopian tube, uterus,cervical stroma, and omentum. The right ovary and tube were healthy. On histopathological examination,the final diagnosis of primary mucinous ovarian carcinoma was made. The patient toleratedstaging laparotomy (total abdominal hysterectomy with bilateral salpingo-oophorectomy and infracolicomentectomy) well and was started on six cycles of adjuvant chemotherapy with Paclitaxeland Carboplatin injections along with Bevacizumab.Primary mucinous ovarian carcinomas are rare and distinct subtypes of epithelial ovariancarcinomas. Due to their strong resemblance to other ovarian tumors and leiomyosarcoma, theirdiagnosis becomes challenging. Hence, it is crucial to consider leiomyosarcomas in the differentialdiagnosis of ovarian masses, especially in postmenopausal women.
一名 60 岁的绝经后妇女因腹部疼痛 2-3 个月,食欲不振伴体重下降 1-2 个月到妇科门诊就诊。经超声波和核磁共振检查,她被诊断为子宫肌瘤或左侧附件肿物。术中,她被诊断为单侧左侧卵巢恶性肿瘤,主要为实性,并转移至左侧输卵管、子宫、宫颈间质和网膜。右侧卵巢和输卵管健康。经组织病理学检查,最终诊断为原发性粘液性卵巢癌。患者对分期开腹手术(全腹子宫切除术,双侧输卵管卵巢切除术和结肠下切除术)耐受良好,并开始接受六个周期的辅助化疗,包括紫杉醇卡铂注射和贝伐单抗。原发性粘液性卵巢癌是上皮性卵巢癌中罕见而独特的亚型。原发性粘液性卵巢癌是一种罕见而独特的上皮性卵巢癌亚型,由于其与其他卵巢肿瘤和卵巢黏液肉瘤非常相似,因此其诊断极具挑战性。因此,在卵巢肿块的鉴别诊断中考虑子宫肌瘤至关重要,尤其是绝经后妇女。
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引用次数: 0
The Childbirth Experience: A Systematic Review on Prenatal and Intrapartum Supportive Interventions 分娩体验:产前和产中支持性干预系统回顾
IF 0.4 Q3 Medicine Pub Date : 2024-03-15 DOI: 10.2174/0115734048285845240313085858
J.M. Seno Adjie, Janice Priscilla, Fahira Nada Safira
The incidence of challenging delivering experiences varies among societiesand is impacted by various factors. The primary goal of this review was to assess the effect ofsupportive interventions pre- and during delivery on the likelihood of a positive childbirth experience.This study reviewed articles related to childbirth experience in international databases,such as PubMed, Cochrane, and ScienceDirect. A total of 1433 articles were found using thePRISMA guideline. Review research emphasized the supporting interventions during labor andwomen's subjective experience. Quality assessment was conducted using the modified Jadad scale.Overall, fifteen studies passed the eligibility criteria. The effective approaches to develop afavorable understanding of the whole birthing process encompassed the following supportive interventions:yoga exercise during pregnancy, antenatal hypnosis program, continuous supportive careduring labor, family companion during labor, massage during labor, therapeutic touch program, acupressureduring labor, birth ball exercise during labor, warm showers during the first stage, anddancing with music during the active phase of labor.Various supportive interventions related to childbirth may reduce pain and anxiety,build confidence, encourage, and serve as valuable psychosocial interventions for childbirth. Becominga mother is not a frequent occurrence for all women, contributing to an overall experiencein childbirth. Our study recommends interventions, such as yoga exercises during pregnancy, an antenatalhypnosis program, continuous supportive care during labor, a family companion during labor,massage during labor, a therapeutic touch program, acupressure during labor, birth ball exerciseduring labor, warm showers during the first stage, and dancing with music during the activephase of labor.
具有挑战性的分娩经历的发生率因社会而异,并受到各种因素的影响。本研究在 PubMed、Cochrane 和 ScienceDirect 等国际数据库中查阅了与分娩经历相关的文章。本研究在 PubMed、Cochrane 和 ScienceDirect 等国际数据库中查阅了与分娩体验相关的文章,并采用PRISMA 指南找到了 1433 篇文章。综述研究强调了分娩过程中的辅助干预措施和妇女的主观体验。总体而言,有 15 项研究通过了资格审查。对整个分娩过程形成良好理解的有效方法包括以下支持性干预措施:孕期瑜伽运动、产前催眠计划、分娩期持续支持性护理、分娩期家庭陪伴、分娩期按摩、治疗性抚触计划、分娩期穴位按摩、分娩期分娩球运动、第一产程温水淋浴、分娩活跃期音乐伴舞。并非所有妇女都能经常成为母亲,这也是分娩过程中整体体验的一部分。我们的研究建议采取一些干预措施,如孕期瑜伽练习、产前催眠计划、分娩过程中的持续支持性护理、分娩过程中的家人陪伴、分娩过程中的按摩、治疗性抚触计划、分娩过程中的穴位按摩、分娩过程中的分娩球运动、第一产程中的温水淋浴、分娩活跃期的音乐伴舞等。
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引用次数: 0
Current Trends and Future Strategies on Diagnosis and Management ofAdenomyosis: An Updated Review 诊断和治疗子宫腺肌症的当前趋势和未来策略:最新综述
IF 0.4 Q3 Medicine Pub Date : 2024-03-11 DOI: 10.2174/0115734048265172231018071749
Rizwana Bee, Mohammad Ahmad, S. Verma, Ritesh kumar Tiwari
This aim of the study was to gather information for use in the present and future managementof the adenomyosis condition. Adenomyosis is a benign gynecological condition thatneeds to be managed for the rest of one's life with either medication or surgical treatment. It is alsoassociated with abnormal uterine bleeding, dysmenorrhea, dyspareunia, and infertility. Thechoice a woman makes will be influenced by her age, reproductive status, and clinical indicators.The primary goals of this study were to gain knowledge on adenomyosis and to review potentialtreatment possibilities. According to this review, adenomyosis can be treated in a number of ways,including through medical attention utilizing least-invasive techniques a surgical operation that isperformed with minimally invasive techniques. Focused ultrasound with high intensity (HIFU) forhysteroscopic ablation and resection Embolishing the uterine artery (UAE). Adenomyosis is a benigngynecological illness that necessitates a lifelong care strategy by medication or surgical therapyand is accompanied by abnormal uterine hemorrhage, dysmenorrhea, dyspareunia, and infertility.The option a woman chooses will depend on her age, reproductive status, and clinical signs.Since there is currently no medication approved for the treatment of adenomyosis, the present reviewwill focus on existing and future medical procedures for the condition. The uterus is impactedby the medical condition adenomyosis. It happens when the endometrial tissue that normallylines the uterus invades the myometrium, the uterine muscle wall. Although this illness is benign,some people may experience substantial pain and discomfort as a result of it. It is more typicallydetected in those who have had children and is most frequently diagnosed in people between theages of 30 and 50. Treatment options depend on the severity of symptoms and the individual's specificsituation. Treatment approaches may include Pain Management, Hormonal Therapy, SurgicalInterventions, Surgical Interventions and Lifestyle Changes. Several uterine-sparing therapeutic alternativesare currently available, each with unique risks and benefits, such as medication, hysteroscopicresection or ablation, conservative surgical methods, and high-intensity focused ultrasound.Uterine artery embolization, a practical, secure, and cost-effective method for treating uterine fibroids,has recently grown in popularity as a treatment for uterine adenomyosis.
这项研究的目的是收集相关信息,以用于目前和未来对腺肌症的管理。子宫腺肌症是一种良性妇科疾病,需要通过药物或手术治疗进行终生管理。它还与异常子宫出血、痛经、排便困难和不孕有关。妇女的选择会受到其年龄、生育状况和临床指标的影响。本研究的主要目的是了解子宫腺肌症的相关知识,并回顾潜在的治疗可能性。根据该综述,子宫腺肌症的治疗方法有很多,包括利用微创技术进行的外科手术。高强度聚焦超声(HIFU)用于宫腔镜消融和切除 子宫动脉栓塞(UAE)。子宫腺肌症是一种良性妇科疾病,需要采取药物或手术治疗的终生护理策略,并伴有异常子宫出血、痛经、排便困难和不孕症。子宫受到子宫腺肌症的影响。当子宫内膜组织侵入子宫肌层(子宫肌壁)时,子宫就会受到影响。虽然这种疾病是良性的,但有些人可能会因此而感到剧烈疼痛和不适。这种疾病通常在生过孩子的人中被发现,最常在 30 至 50 岁的人群中被诊断出来。治疗方案取决于症状的严重程度和个人的具体情况。治疗方法可能包括疼痛控制、荷尔蒙疗法、外科干预、手术干预和改变生活方式。子宫动脉栓塞术是治疗子宫肌瘤的一种实用、安全、经济的方法,最近作为子宫腺肌症的一种治疗方法越来越受欢迎。
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引用次数: 0
Exploring Women’s Childbirth Experiences in Labor Induction versus Expectant Management: A Systematic Review and Meta-analysis 探索妇女在引产与待产管理中的分娩体验:系统回顾和元分析
IF 0.4 Q3 Medicine Pub Date : 2024-03-07 DOI: 10.2174/0115734048285132240229084803
J.M. Seno Adjie, Teresa Catalina R., Janice Priscilla
Negative childbirth experiences impact the well-being of women and theirfamilies. With rising induction of labor (IOL) rates and the inconsistent evidence regarding itsimpact on childbirth experiences, we conducted a systematic review and meta-analysis to estimatethe overall effect of IOL versus expectant management on women’s childbirth experiences, definedas a woman’s self-assessment of her lasting memories of the childbirth event.We searched databases (PubMed, Embase, Cochrane Library, Science Direct, ProQuestand EBSCO) for RCTs and observational studies from 1970 to September 2023. Inclusion criteriacovered women aged 19 and older with live, singleton, cephalic pregnancies at 37 0/7 until 41 6/7weeks gestation. Quality was assessed using the Jadad and Newcastle-Ottawa Scales. RevMan 5.4software and random-effects meta-analysis were used, adhering to PRISMA guidelines.Of the 1.467 screened articles, we included nine studies from five European countries. Sixstudies (2.376 women) used the Childbirth Experience Questionnaire (CEQ). Overall CEQ scoresshowed no significant IOL vs. expectant management differences (MD = 0.01 [95% CI -0.06, 0.08];p=0.78; I2 = 65%). Subgroup analyses favored IOL in RCTs (MD = 0.07 [95% CI 0.02, 0.13];p=0.006; I2 = 0%) and studies with ≥500 participants (MD = 0.09 [95% CI 0.02, 0.15]; p=0.006; I2= 0%). Conversely, four studies (48.324 women) using the Childbirth Experience Visual AnalogueScale (VAS) favored expectant management (OR = 0.73 [95% CI 0.63, 0.85]; p<0.001; I2 = 86%).VAS assessments suggest a more positive childbirth experience with the expectantmanagement group. Improvements in the IOL process, transfer to delivery, and pain reliefadministration may benefit the IOL group. In contrast, the overall CEQ scores did not significantlydiffer between groups. Clinical practice should consider individualized approaches that align withpatient needs and medical contexts. Limitations, such as variability in study quality and dataheterogeneity, should be acknowledged.CRD42023464153
负面的分娩经历会影响妇女及其家庭的幸福。随着引产(IOL)率的上升以及有关引产对分娩经历影响的证据不一致,我们进行了一项系统性回顾和荟萃分析,以估算引产与待产管理对妇女分娩经历的总体影响,即妇女对其分娩事件持久记忆的自我评估。纳入标准包括妊娠 37 0/7 周至 41 6/7 周的 19 岁及以上活产、单胎、头位妊娠妇女。采用 Jadad 和纽卡斯尔-渥太华量表进行质量评估。在筛选出的 1467 篇文章中,我们纳入了来自 5 个欧洲国家的 9 项研究。六项研究(2376 名妇女)使用了分娩体验问卷(CEQ)。CEQ 的总体调查结果显示,IOL 与预产期管理没有明显差异(MD = 0.01 [95% CI -0.06, 0.08];P=0.78;I2 = 65%)。亚组分析显示,RCT(MD = 0.07 [95% CI 0.02, 0.13];p=0.006;I2 = 0%)和参与人数≥500 人的研究(MD = 0.09 [95% CI 0.02, 0.15];p=0.006;I2= 0%)更倾向于 IOL。相反,四项使用分娩体验视觉模拟量表(VAS)的研究(48 324 名妇女)倾向于期待管理组(OR = 0.73 [95% CI 0.63, 0.85];p<0.001;I2 = 86%)。VAS评估结果表明,期待管理组的分娩体验更积极。IOL流程、分娩转运和镇痛管理方面的改进可能会使IOL组受益。相比之下,各组之间的 CEQ 总分没有明显差异。临床实践应考虑符合患者需求和医疗环境的个性化方法。应认识到研究的局限性,如研究质量的差异性和数据的异质性。
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引用次数: 0
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Current Women s Health Reviews
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