Pub Date : 2024-07-04DOI: 10.2174/0115734048286695240627060120
L. Pourali, A. Vatanchi, H. Majd, N. Ghomian, Solaleh Jabarzadeh
Methotrexate (MTX) was traditionally administered using the multi-dose regimen or single-dose protocols to treat ectopic pregnancies. The two-dose regimen was described as a cross between these two previous protocols aiming to lower side effects than multi-dose with a higher success rate of single-dose protocols. Hence, this study compared double-dose versus singledose methotrexate therapy in the treatment of ectopic pregnancy. This prospective cohort study was performed on the women referred to the academic hospitals of Mashhad University of Medical Sciences from March 2018 to July 2021 who were diagnosed as having stable tubal ectopic pregnancy and selected for medical treatment with methotrexate. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) software (version 26). P≤0.05 was considered a significant level. A total number of 347 patients were included in this study. About 300 cases were evaluated: 240 cases in single-dose and 60 cases in the double-dose group. The Beta Human chorionic gonadotropin (Beta-hCG) declined more than 15% between days 4 and 7 and was significantly higher in the double-dose group (P<0.001). Regarding the time from MTX administration until Beta- hCG level <5mIU/mg, this time was significantly shorter in the double-dose group (P=0.045). Considering the side effects, there was no complication in any of the groups. However, tubal rupture was seen in 17 cases of double-dose and 10 cases in the single-dose group, respectively. The results of the current study showed a higher treatment success rate in double-dose MTX protocol with comparable side effects compared to single-dose MTX protocol for the treatment of stable tubal ectopic pregnancy.
{"title":"Double-dose Versus Single-dose Methotrexate Therapy in Treatment of Ectopic Pregnancy","authors":"L. Pourali, A. Vatanchi, H. Majd, N. Ghomian, Solaleh Jabarzadeh","doi":"10.2174/0115734048286695240627060120","DOIUrl":"https://doi.org/10.2174/0115734048286695240627060120","url":null,"abstract":"\u0000\u0000Methotrexate (MTX) was traditionally administered using the multi-dose\u0000regimen or single-dose protocols to treat ectopic pregnancies. The two-dose regimen was described\u0000as a cross between these two previous protocols aiming to lower side effects than multi-dose with a\u0000higher success rate of single-dose protocols. Hence, this study compared double-dose versus singledose\u0000methotrexate therapy in the treatment of ectopic pregnancy.\u0000\u0000\u0000\u0000This prospective cohort study was performed on the women referred to the academic\u0000hospitals of Mashhad University of Medical Sciences from March 2018 to July 2021 who were diagnosed\u0000as having stable tubal ectopic pregnancy and selected for medical treatment with methotrexate.\u0000Statistical analysis was performed using the Statistical Package for the Social Sciences\u0000(SPSS) software (version 26). P≤0.05 was considered a significant level.\u0000\u0000\u0000\u0000A total number of 347 patients were included in this study. About 300 cases were evaluated:\u0000240 cases in single-dose and 60 cases in the double-dose group. The Beta Human chorionic\u0000gonadotropin (Beta-hCG) declined more than 15% between days 4 and 7 and was significantly\u0000higher in the double-dose group (P<0.001). Regarding the time from MTX administration until Beta-\u0000hCG level <5mIU/mg, this time was significantly shorter in the double-dose group (P=0.045).\u0000Considering the side effects, there was no complication in any of the groups. However, tubal rupture\u0000was seen in 17 cases of double-dose and 10 cases in the single-dose group, respectively.\u0000\u0000\u0000\u0000The results of the current study showed a higher treatment success rate in double-dose\u0000MTX protocol with comparable side effects compared to single-dose MTX protocol for the treatment\u0000of stable tubal ectopic pregnancy.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.2174/0115734048287230240429171400
N. Radnia, E. Talebi-Ghane, Heydar Tavilani, Maryam Garousian, Neda Alimohammadi, Marzieh Ghorbani
The data indicated that out of 114175 deliveries, there were 60 hysterectomies over 14 years with the age range of 20-45 years. The incidence of hysterectomy increased from 0.34/1000 during 2009-2015 to 0.71/1000 deliveries in 2015-2022, with an overall incidence of 0.53 per 1000 deliveries during 14 years. The results indicated that the mean rate of hysterectomy (0.95% CI) increased significantly by 0.059 yearly, and by adjusting other variables, the history of CS (0.95% CI) and placenta accreta previa significantly increased the hysterectomy mean rate by 0.291 (0.053- 0.529) and 0.284 (0.074-0.494), respectively. The mean rate of hysterectomy represented an annual increase, especially during the last 7 years. In summary, the main reason can be the history of CS that leads to placental disorders and, thus, hysterectomy.
{"title":"The Trend of Cesarean Hysterectomy in Hamadan, Iran, between 2009-2022","authors":"N. Radnia, E. Talebi-Ghane, Heydar Tavilani, Maryam Garousian, Neda Alimohammadi, Marzieh Ghorbani","doi":"10.2174/0115734048287230240429171400","DOIUrl":"https://doi.org/10.2174/0115734048287230240429171400","url":null,"abstract":"\u0000\u0000The data indicated that out of 114175 deliveries, there were 60 hysterectomies over 14\u0000years with the age range of 20-45 years. The incidence of hysterectomy increased from 0.34/1000\u0000during 2009-2015 to 0.71/1000 deliveries in 2015-2022, with an overall incidence of 0.53 per 1000\u0000deliveries during 14 years. The results indicated that the mean rate of hysterectomy (0.95% CI) increased\u0000significantly by 0.059 yearly, and by adjusting other variables, the history of CS (0.95% CI)\u0000and placenta accreta previa significantly increased the hysterectomy mean rate by 0.291 (0.053-\u00000.529) and 0.284 (0.074-0.494), respectively.\u0000\u0000\u0000\u0000The mean rate of hysterectomy represented an annual increase, especially during the\u0000last 7 years. In summary, the main reason can be the history of CS that leads to placental disorders\u0000and, thus, hysterectomy.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.2174/0115734048280294240429115337
S. Hashemi, Farrokh Modarresi, A. Esmailzadeh, Nazanin Zeinab Sheikhsofla
Cervical cancer is reported as one of the most prevalent malignancies worldwide in women. There is a substantial connection between cervical diseases and infection with Human Papillomavirus (HPV), especially Types 16 and 18 of HPV. This study aimed to assess the HPV genotype distribution to determine its most common type at a referral hospital in Iran. This cross-sectional study was conducted on 400 women with positive HPV result tests who visited the gynecologic oncology clinic of Baqiyatallah Hospital from 2017-2021. The average age of subjects was 37.46±9.75 years (range=19-74). About 167 (41.8%) of the patients were between 25 to 35 years. The analysis showed that 137 (34.2%) patients had only low-risk (LR) typing, 129 (32.2%) patients had only high-risk (HR) typing, and 134 (33.5%) patients had both HR and LR typing. The most frequent LR HPV types were HPV 6 (18.5%) and 11 (17%), and the most frequent HR HPV types were HPV-16 (14.7%), 52 (8.2%), 18, and 31 (6.5%). This study showed that the most frequent age category in both low- and HR HPVpositive women is the age 25 to 35 years. The second most common HR-HPV subtypes included HPV-52, not HPV-18, which indicates variations in HR-HPV subtypes in different populations and races and warrants further research.
{"title":"Human Papillomavirus Genotype Distribution in a Hospital-based\u0000Single-Center Study","authors":"S. Hashemi, Farrokh Modarresi, A. Esmailzadeh, Nazanin Zeinab Sheikhsofla","doi":"10.2174/0115734048280294240429115337","DOIUrl":"https://doi.org/10.2174/0115734048280294240429115337","url":null,"abstract":"\u0000\u0000Cervical cancer is reported as one of the most prevalent malignancies\u0000worldwide in women. There is a substantial connection between cervical diseases and infection\u0000with Human Papillomavirus (HPV), especially Types 16 and 18 of HPV.\u0000\u0000\u0000\u0000This study aimed to assess the HPV genotype distribution to determine its most common\u0000type at a referral hospital in Iran.\u0000\u0000\u0000\u0000This cross-sectional study was conducted on 400 women with positive HPV result tests\u0000who visited the gynecologic oncology clinic of Baqiyatallah Hospital from 2017-2021.\u0000\u0000\u0000\u0000The average age of subjects was 37.46±9.75 years (range=19-74). About 167 (41.8%) of\u0000the patients were between 25 to 35 years. The analysis showed that 137 (34.2%) patients had only\u0000low-risk (LR) typing, 129 (32.2%) patients had only high-risk (HR) typing, and 134 (33.5%) patients had both HR and LR typing. The most frequent LR HPV types were HPV 6 (18.5%) and 11\u0000(17%), and the most frequent HR HPV types were HPV-16 (14.7%), 52 (8.2%), 18, and 31 (6.5%).\u0000\u0000\u0000\u0000This study showed that the most frequent age category in both low- and HR HPVpositive women is the age 25 to 35 years. The second most common HR-HPV subtypes included\u0000HPV-52, not HPV-18, which indicates variations in HR-HPV subtypes in different populations and\u0000races and warrants further research.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}