Ameliorated antimicrobial, antioxidant, and anticancer properties by Plectranthus vettiveroides root extract-mediated green synthesis of chitosan nanoparticles

IF 3.8 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY Green Processing and Synthesis Pub Date : 2023-01-01 DOI:10.1515/gps-2023-0086
Kamalesh Balakumar Venkatesan, Saravanan Alamelu, Sivamathi Rathna Priya, Nivedha Jayaseelan, Sathish-Kumar Kamaraj, Manoj Kumar Srinivasan, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Ahmed Saif, Selvendiran Periyasamy
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Abstract

Abstract In this investigation, using the biogenic approach, Plectranthus vettiveroides root extract was used to synthesize chitosan nanoparticles ( P. vettiveroides CNPs). The produced nanoparticles (NPs) were characterized using UV-visible (UV/vis) absorption spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The typical absorption peaks in the UV/vis spectra were located around 253 nm. Functional groups were identified in P. vettiveroides CNPs by FTIR. As per SEM analysis, the NPs generated exhibited a spherical shape with an average diameter of 78.01 nm. In addition, the synthesized P. vettiveroides CNPs were examined for antioxidant and antibacterial properties and anticancer activities. They show a strong antioxidant activity compared to butylated hydroxytoluene as a standard antioxidant. P. vettiveroides root extract CNPs demonstrated the most significant zone of inhibition against Klebsiella pneumoniae (22 mm), followed by Escherichia coli (21 mm), Bacillus cereus (19 mm), and Staphylococcus aureus (17 mm). In addition, using MTT assay, anticancer efficacy against KB (oral cancer) cells was studied. The cytotoxic reaction was observed in a dosage-dependent manner. P. vettiveroides CNPs show bioefficacy because of their size and the existence of bioactive compounds, which can enhance antibacterial and anticancer activities by lysing bacterial and cancer cell walls.
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中药根提取物介导的绿色合成壳聚糖纳米颗粒改善了抗菌、抗氧化和抗癌性能
摘要本研究采用生物源法,以草根提取物为原料合成壳聚糖纳米颗粒(P. vettiveroides CNPs)。利用紫外-可见(UV/vis)吸收光谱、傅里叶变换红外(FTIR)光谱和扫描电子显微镜(SEM)对制备的纳米颗粒(NPs)进行了表征。紫外/可见光谱的典型吸收峰位于253 nm左右。利用傅里叶变换红外光谱(FTIR)鉴定了香根草CNPs中的官能团。SEM分析表明,合成的纳米粒子呈球形,平均直径为78.01 nm。此外,还对合成的香根草属植物CNPs进行了抗氧化、抗菌和抗癌活性的研究。与作为标准抗氧化剂的丁基羟基甲苯相比,它们显示出较强的抗氧化活性。根提取物CNPs对肺炎克雷伯菌(22 mm)的抑制作用最显著,其次是大肠杆菌(21 mm)、蜡样芽孢杆菌(19 mm)和金黄色葡萄球菌(17 mm)。此外,采用MTT法研究其对口腔癌细胞的抗癌作用。细胞毒性反应呈剂量依赖性。P. vettiveroides CNPs由于其大小和存在的生物活性化合物而具有生物功效,可以通过裂解细菌和癌细胞壁来增强抗菌和抗癌活性。
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来源期刊
Green Processing and Synthesis
Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL
CiteScore
6.70
自引率
9.30%
发文量
78
审稿时长
7 weeks
期刊介绍: Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.
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