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Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method 采用绿色反相 HPTLC 法同时估算商业产品中的布洛芬、咖啡因和扑热息痛
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0220
M. Alqarni, F. Shakeel, S. Alshehri, A. Foudah, T. M. Aljarba, Fatma Abdel Bar, P. Alam
A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.
本研究建立并验证了一种快速、灵敏、绿色的反相 "高效薄层色谱 "方法,用于同时测定市售制剂中的布洛芬(IBF)、咖啡因(CAF)和扑热息痛(PCM)。采用丙酮和水(80:20 v/v)的二元组合作为绿色洗脱体系。使用四种不同的方法,即国家环境方法指数法、分析生态分数法(89)、氯毒法(1.08 g)和分析绿色度法(83)预测了当前方法的绿色程度,结果表明该方法具有突出的绿色特性。本方法在 25-800 纳克-带-1 范围内线性良好,可同时估计 IBF、CAF 和 PCM。此外,该方法准确(回收率 = 100 ± 2%)、精确(%CV < 2%)、稳健(%CV < 2%)、灵敏(LOD = 1.13-2.71 ng-band-1 和 LOQ = 3.39-8.10 ng-band-1)且绿色环保。经测定,商品片剂中 IBF、CAF 和 PCM 的含量分别为 99.51%、98.25% 和 100.64%。这些数据为本方法同时测定市售片剂中 IBF、CAF 和 PCM 的含量提供了支持。研究结果表明,目前的方法可用于分析市售片剂中的 IBF、CAF 和 PCM。
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引用次数: 0
Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions 辣椒素纳米颗粒的合成与表征:尝试提高辣椒素的生物利用度和药理作用
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0206
M. Sher, Ishtiaq Hussain, Farhat Ali Khan, Muhammad Zahoor, Wiaam Mujahid Sher, Muhammad Saqib Khalil, Muhammad Sulaiman, Riaz Ullah, Sumaira Naz, Essam A. Ali
Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin.
本文采用两种不同的方法制备了辣椒素纳米颗粒(NPs),即纳米悬浮液蒸发沉淀法(EPN)和注射泵反溶剂沉淀法(APSP)。通过优化溶剂与反溶剂的比例和搅拌速度等实验参数,制备出了所需尺寸的纳米颗粒。采用 EPN 和 APSP 方法制备的纳米粒子呈球形,平均直径分别为 171.29 ± 1.94 nm 和 78.91 ± 0.54 nm。差示扫描量热法和 X 射线衍射仪显示辣椒素结晶度降低。傅立叶变换红外光谱(FTIR)结果表明,制备的 NPs 具有原始结构,没有合成任何其他结构。NP 配方具有理想的药物含量。它们的溶解度超过了未加工的药物,并显示出理想的稳定性。与未加工的辣椒素相比,辣椒素 NP 霜的镇痛、消炎和抗菌效果增强了数倍。
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引用次数: 0
Green polymer electrolyte and activated charcoal-based supercapacitor for energy harvesting application: Electrochemical characteristics 基于绿色聚合物电解质和活性炭的能量收集应用超级电容器:电化学特性
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0109
S. B. Aziz, M. H. Hamsan, Rebar T. Abdulwahid, N. A. Halim, Jamal Hassan, Ahmed F. Abdulrahman, Sameerah I. Al-Saeedi, Jihad M. Hadi, M. Kadir, Samir M. Hamad, Salah R. Saeed
The aim of this study is to address the growing concern about microplastics in the ocean and their potential harm to human health through ingestion. The MPs issue is largely a result of the increasing demand for electronic devices and their components. To tackle this challenge, the research aimed to develop a green polymer electrolyte that used glycerol as a plasticizing agent to improve ionic conductivity. The polymer host included chitosan and polyvinyl alcohol and was composed of sodium acetate. To evaluate the performance of the polymer electrolyte, various analytical techniques were used, including impedance and electrochemical studies. The ionic conductivity of 7.56 × 10−5 S·cm−1 was recorded. The dielectric property study confirmed the ionic conduction process in the system and revealed the existence of non-Debye type relaxation, as indicated by asymmetric peaks of tanδ spectra. The alternating conductivity exhibits three distinguished regions. The polymer electrolyte was discovered to be electrochemically stable up to 2.33 V and capable of storing energy as a non-Faradaic electrochemical double-layer capacitor (EDLC). The cyclic voltammetry pattern is a leaf like shape. The EDLC was able to be charged and discharged up to 1 V, and it showed cyclability and could be used in low-voltage applications.
这项研究旨在解决人们日益关注的海洋中的微塑料及其摄入对人类健康的潜在危害问题。微塑料问题在很大程度上是由于对电子设备及其组件的需求日益增长造成的。为应对这一挑战,该研究旨在开发一种绿色聚合物电解质,使用甘油作为增塑剂来提高离子导电性。聚合物宿主包括壳聚糖和聚乙烯醇,并由醋酸钠组成。为了评估聚合物电解质的性能,使用了各种分析技术,包括阻抗和电化学研究。记录到的离子电导率为 7.56 × 10-5 S-cm-1。介电性能研究证实了体系中的离子传导过程,并揭示了非德拜型弛豫的存在,如 tanδ 光谱的不对称峰所示。交变导电性呈现出三个不同的区域。研究发现,这种聚合物电解质的电化学稳定性高达 2.33 V,能够作为非法拉第电化学双层电容器(EDLC)储存能量。循环伏安模式呈树叶状。EDLC 的充放电电压可达 1 V,具有循环性,可用于低压应用。
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引用次数: 0
Membrane distillation of synthetic urine for use in space structural habitat systems 膜蒸馏合成尿液,用于太空结构栖息地系统
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0197
V. Sagar, Lauren M. Mekalip, J. Lynam
Low-energy separation of potable water from urine is an important area of research, particularly if humans hope to transcend their earth-bound origins. The high cost of water in rocket payloads means that it must be recycled and the byproducts of the crew used productively. Direct Contact Membrane Distillation (DCMD) can use low heat sources to separate water from urea, which can then be used as a plasticizer in regolith-based cement to make it more workable. In the present study, traditional cement curing was compared to vacuum curing for regolith-based cement where artificial urine, concentrated using DCMD, was added as a plasticizer. Increases in workability were found for increasing concentrations of urea. Porosity also tended to increase with increasing urea concentration. Surprisingly, Lunar Highlands Simulant regolith-based batches with urea that were cured under vacuum showed higher compressive strengths than those cured traditionally. No literature is available for DCMD use with urine, indicating that this research is novel and could have widespread applications, such as in desert environments or public urinals.
从尿液中低能分离饮用水是一个重要的研究领域,特别是如果人类希望超越其地球起源的话。火箭有效载荷中水的成本很高,这意味着必须对水进行回收,并对乘员的副产品进行有效利用。直接接触膜蒸馏(DCMD)可以利用低热源将水从尿素中分离出来,然后将尿素用作基于碎石的水泥中的增塑剂,使其更具可加工性。在本研究中,将传统的水泥固化与真空固化进行了比较,在真空固化中加入了使用 DCMD 浓缩的人造尿液作为增塑剂。结果发现,尿素浓度越高,可加工性越好。孔隙率也随着尿素浓度的增加而增加。令人惊讶的是,在真空条件下固化的月球高地模拟雷灰岩基尿素批次显示出比传统固化方法更高的抗压强度。目前还没有关于将 DCMD 用于尿液的文献,这表明这项研究具有新颖性,可广泛应用于沙漠环境或公共小便池等领域。
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引用次数: 0
Investigation on mechanical properties of the green synthesis bamboo fiber/eggshell/coconut shell powder-based hybrid biocomposites under NaOH conditions NaOH 条件下绿色合成竹纤维/蛋壳/椰壳粉基混合生物复合材料力学性能的研究
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0185
L. Natrayan, Neelima Devi Chinta, Balakrishna Gogulamudi, V. Swamy Nadh, G. Muthu, S. Kaliappan, Chidurala Srinivas
This research delves into the effects of different alkalization treatment approaches on the mechanical characteristics of epoxy matrix composites that are reinforced with natural bamboo fibers and enriched with egg and coconut shell powders as fillers. Various weight ratios of fibers and fillers were investigated, specifically at 5%, 10%, 15%, 20%, 25%, and 30%. The study assessed mechanical properties such as tensile strength, flexural behavior, microhardness, and impact resilience. Findings indicate that composites with alkali-treated fibers demonstrate superior mechanical performance (49.28 MPa of tensile, 57.33 MPa of flexural 89 HV of hardness, and 1.3 kJ·m−2 of impact) compared to untreated counterparts. Particularly noteworthy is the significant improvement in fracture toughness observed with the inclusion of 20% hybrid laminates, surpassing the performance of existing biomaterial-based composites. This heightened toughness is attributed to the optimized composition of fibers and enhanced water absorption capabilities. Conversely, the incorporation of 25% and 30% hybrid composites led to a decrease in mechanical strength (38.65 MPa of tensile, 46.7 MPa of flexural, 72 HV of hardness, and 1.19 kJ·m−2 of impact) due to the formation of additional interfacial contacts, pores, and voids within the polymeric matrix.
本研究探讨了不同碱化处理方法对天然竹纤维增强环氧基复合材料机械特性的影响,并添加了鸡蛋和椰子壳粉作为填料。研究了纤维和填料的各种重量比,特别是 5%、10%、15%、20%、25% 和 30%。研究评估了拉伸强度、弯曲性能、微硬度和冲击回弹性等机械性能。研究结果表明,与未经处理的同类材料相比,经过碱处理的纤维复合材料具有更优越的机械性能(拉伸强度为 49.28 兆帕、弯曲强度为 57.33 兆帕、硬度为 89 HV、冲击韧性为 1.3 kJ-m-2)。尤其值得注意的是,加入 20% 混合层压材料后,断裂韧性显著提高,超过了现有生物材料基复合材料的性能。这种韧性的提高归功于纤维成分的优化和吸水能力的增强。相反,加入 25% 和 30% 的杂化复合材料会导致机械强度下降(拉伸强度为 38.65 兆帕、弯曲强度为 46.7 兆帕、硬度为 72 HV、冲击强度为 1.19 kJ-m-2),原因是聚合物基质中形成了额外的界面接触、孔隙和空隙。
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引用次数: 0
Facile, polyherbal drug-mediated green synthesis of CuO nanoparticles and their potent biological applications 多草药介导的 CuO 纳米粒子的简便绿色合成及其强效生物应用
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0174
Mohammad Azam Ansari, Hassan Nassr Al Dhneem, S. G. Ali, Yahya F. Jamous, M. Alomary, Banan Atwah, Maryam S. Alhumaidi, Umme Hani, Nazima Haider, S. Asiri, F. A. Khan
Copper oxide nanoparticles (CuO NPs) were synthesized using ayurvedic medicine septilin. The septilin-mediated CuO NPs were characterized using UV–Vis, fourier-transform infrared spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscope (TEM). The average particle size of CuO NPs was 8 nm as evident from TEM. Minimum inhibitory concentration of CuO NPs against Escherichia coli, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans was found in the range of 1–2.5 mg·mL−1. CuO NPs dose-dependently decreased the biofilm formation from 0.0315 to 2 mg·mL−1, at the highest dose of 2 mg·mL−1 of CuO NPs; 92.91%, 79.84%, and 71.57% decrease in biofilm was observed for P. aeruginosa, MRSA, and C. albicans, respectively. Down-regulation of biofilm upon treatment with nanoparticles (NPs) was also observed by SEM analysis. SEM analysis also showed the change in morphological structure, and deformities in bacterial and fungal cells upon treatment of NPs. Furthermore, the anticancer efficacy of NPs was assessed using colon cancer (HCT-116). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay clearly showed the anticancer potential of NPs, as the concentration of CuO NPs increased, the number of viable cells decreased. The produced CuO NPs have promise for future investigations in many biological and therapeutic domains, including the treatment of microbial biofilm infections, as well as the inhibition of cancer cell growth.
利用阿育吠陀药七叶皂苷(septilin)合成了氧化铜纳米粒子(CuO NPs)。使用紫外-可见光谱、傅立叶变换红外光谱、X射线衍射(XRD)、扫描电子显微镜(SEM)和透射电子显微镜(TEM)对septilin介导的CuO NPs进行了表征。从 TEM 可见,CuO NPs 的平均粒径为 8 nm。CuO NPs 对大肠杆菌、绿脓杆菌、耐甲氧西林金黄色葡萄球菌(MRSA)和白色念珠菌的最小抑制浓度为 1-2.5 mg-mL-1。在 0.0315 至 2 mg-mL-1 的范围内,CuO NPs 可剂量依赖性地减少生物膜的形成,最高剂量为 2 mg-mL-1 时,铜绿假单胞菌、MRSA 和白色念珠菌的生物膜分别减少了 92.91%、79.84% 和 71.57%。通过扫描电镜分析还观察到使用纳米颗粒(NPs)处理后生物膜的减少。扫描电子显微镜分析还显示了经 NPs 处理后细菌和真菌细胞形态结构的变化和畸形。此外,还利用结肠癌(HCT-116)评估了 NPs 的抗癌功效。3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四氮唑试验清楚地表明了 NPs 的抗癌潜力,随着 CuO NPs 浓度的增加,存活细胞的数量减少。所制备的 CuO NPs 未来有望在许多生物和治疗领域开展研究,包括治疗微生物生物膜感染和抑制癌细胞生长。
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引用次数: 0
Biofabrication of silver nanoparticles using Uncaria tomentosa L.: Insight into characterization, antibacterial activities combined with antibiotics, and effect on Triticum aestivum germination 利用云杉生物制造银纳米粒子:深入了解其特性、与抗生素结合的抗菌活性以及对小麦发芽的影响
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0207
R. M. Alghanmi, R. Hamouda, A. Al-Moubaraki, Afnan A. Allouzi, Muhammad A. Abuelmagd
Herein, we used the aqueous extract of Uncaria tomentosa L. barks (Cat’s claw bark [CCb]) for the biofabrication of silver nanoparticles (CCb-Ag-NPs). The effects of different parameters (Uncaria tomentosa L. aqueous extract, silver nitrate [AgNO3] ratio, temperature, and pH) on the formation of the nanoparticles were investigated using UV scan as a preliminary tool for the detection of surface plasmon resonance of CCb-Ag-NPs. The optimal ratio was 1:7 (Uncaria tomentosa L. extract: 1 mM AgNO3 solution). Fourier-transform infrared spectroscopy revealed the functional groups of both CCb extract and the CCb-Ag-NPs, whose dispersion and quasispherical morphologies were characterized using scanning electron microscopy and transmission electron microscopy. Particle sizes ranged from 19.2 to 38.5 nm. The zeta potential of CCb-Ag-NPs was −34.44 mV. According to energy-dispersive X-ray analysis, the CCb-Ag-NPs contained 28.87% silver. The formation of Ag-NPs was also confirmed by X-ray diffraction pattern analysis. Pristine CCb-Ag-NPs showed antibacterial activity against three pathogenic bacterial strains: Escherichia coli (ATCC 25922), E. coli (ATCC 8739), and Pseudomonas aeruginosa (ATCC 90274). Antibacterial activity increased significantly after loading CCb-Ag-NPs on antibiotic discs containing meropenem and cefoxitin. Low concentrations of CCb-Ag-NPs also enhanced the germination percentage, coleoptile length, and radical root length of Triticum aestivum.
在此,我们利用猫爪草树皮(Uncaria tomentosa L. barks [CCb])的水提取物进行银纳米粒子(CCb-Ag-NPs)的生物制造。利用紫外线扫描作为检测 CCb-Ag-NPs 表面等离子体共振的初步工具,研究了不同参数(猫爪树树皮水提取物、硝酸银 [AgNO3] 比例、温度和 pH 值)对纳米粒子形成的影响。最佳比例为 1:7(Uncaria tomentosa L. 提取物:1 mM AgNO3 溶液)。扫描电子显微镜和透射电子显微镜表征了CCb提取物和CCb-Ag-NPs的分散性和准球形形态。颗粒大小为 19.2 至 38.5 nm。CCb-Ag-NPs 的 zeta 电位为 -34.44 mV。根据能量色散 X 射线分析,CCb-Ag-NPs 含有 28.87% 的银。X 射线衍射图样分析也证实了 Ag-NPs 的形成。纯净的 CCb-Ag-NPs 对三种致病细菌菌株具有抗菌活性:大肠杆菌(ATCC 25922)、大肠杆菌(ATCC 8739)和铜绿假单胞菌(ATCC 90274)。在含有美罗培南和头孢西丁的抗生素圆片上添加 CCb-Ag-NPs 后,抗菌活性明显提高。低浓度的 CCb-Ag-NPs 还能提高小麦的发芽率、叶柄长度和根茎长度。
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引用次数: 0
Biosynthesis of silver nanoparticles on yellow phosphorus slag and its application in organic coatings 黄磷渣上银纳米粒子的生物合成及其在有机涂料中的应用
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0204
Nguyen Tien Dung, Duong Tra My, Nguyen Thuy Chinh, Nguyen Quy Dai, Vu Dinh Hieu, Tran Thanh Thuy, Nguyen Kim Thoa, T. Hoang
This work concentrated on the decoration of AgNPs to yellow phosphorus slag (YPS) using both chemical (NaBH4) and biological (Areca catechu nut and Jasminum subtriplinerve leaf extracts) reducing agents, as well as its use as antibacterial and enhancement additives for organic coatings based on acrylic emulsion resin. It is the first study about the decoration of AgNPs on the surface of YPS using bio-reduction agents (A. catechu nut and J. subtriplinerve leaf extracts). The characteristics of YPS decorated by AgNPs (YPS@AgNPs) were determined using attenuated total reflectance infrared spectroscopy, scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy and dynamic light scattering methods. To quantify the amount of AgNPs in YPS@AgNPs, atomic absorption spectroscopy was used. The results of YPS@AgNPs fabrication confirmed that the above green reduction agents had a higher efficiency and were more suitable than the chemical reduction agent (NaBH4). Moreover, the ability to inhibit the growth of bacteria strains of YPS@AgNPs using the J. subtriplinerve leaf extract as a reducing agent gave the best result among the three agents. In particular, the bactericidal activity of YPS@AgNPs against the new marine bacterium, Pseudomonas stutzeri B27, was evaluated, and it was found that YPS@AgNPs can inhibit the growth of an antibiotic-resistant bacterium, P. stutzeri B27. They enhance not only the mechanical properties but also the bactericidal ability of the water-borne acrylic resin coating.
这项工作的重点是利用化学还原剂(NaBH4)和生物还原剂(Areca catechu nut 和 Jasminum subtriplinerve leaf extracts)在黄磷渣(YPS)上装饰 AgNPs,并将其用作基于丙烯酸乳液树脂的有机涂料的抗菌和增强添加剂。这是首次使用生物还原剂(儿茶坚果和次三叶芹叶提取物)在 YPS 表面装饰 AgNPs 的研究。研究采用衰减全反射红外光谱法、扫描电子显微镜法、X 射线衍射法、紫外可见光谱法和动态光散射法测定了被 AgNPs(YPS@AgNPs)装饰的 YPS 的特性。为了量化 YPS@AgNPs 中的 AgNPs 量,使用了原子吸收光谱法。YPS@AgNPs 的制备结果证实,上述绿色还原剂具有更高的效率,比化学还原剂(NaBH4)更合适。此外,以J. subtriplinerve叶提取物为还原剂的YPS@AgNPs抑制菌株生长的能力在三种还原剂中效果最好。特别是评估了 YPS@AgNPs 对新型海洋细菌 P. stutzeri B27 的杀菌活性,结果发现 YPS@AgNPs 可以抑制抗生素耐药菌 P. stutzeri B27 的生长。它们不仅增强了水性丙烯酸树脂涂层的机械性能,还增强了其杀菌能力。
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引用次数: 0
Zinc oxide-manganese oxide/carboxymethyl cellulose-folic acid-sesamol hybrid nanomaterials: A molecularly targeted strategy for advanced triple-negative breast cancer therapy 氧化锌-氧化锰/羧甲基纤维素-叶酸-芝麻酚混合纳米材料:治疗晚期三阴性乳腺癌的分子靶向策略
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0179
Chunming Zhao, Xueqiang Pan, Xiao Li, Meixia Li, Rui Jiang, Yuyang Li
Multifunctional nanocomposites (NC) can greatly enhance therapy outcomes by reducing tumor proliferative potential. We created a novel class of Zn_Mn_CMC_FA_sesamol NC in the current work to combat breast cancer (MDA-MB-231) cells. To understand how zinc (Zn), manganese (Mn), carboxymethylcellulose, and folic acid (FA) interact with sesamol, UV-Visible spectrophotometer and Fourier Transform Infrared spectroscopy were used to analyze the absorption behavior of the synthesized NC. The particle size of NC was confirmed by X-ray diffraction and dynamic light scattering. Scanning electron microscopy was used to assess the morphological features of these NCs. photoluminescence spectrum was used to analyze the optical and electron transition molecules of the sample. In addition to MTT analysis, acridine orange/ethidium bromide (AO/EtBr) analysis of reactive oxygen species (ROS) and nuclear staining with 4′,6-diamidino-2-phenylindole as well as flow cytometry were used to confirm the apoptotic activity of Zn_Mn_CMC_FA_sesamol NC on MDA-MB-231 cells. The results showed significant cytotoxicity, apoptosis induction on AO/EtBr, and increased ROS production in treated cells compared to control cells. The cell cycle analysis revealed that NCs triggered apoptosis and arrested the cell cycle in G0/G1 phases. As a conclusion, the created NC serves as a versatile platform for the successful molecularly targeted chemotherapeutic treatment of cancer.
多功能纳米复合材料(NC)可降低肿瘤的增殖潜力,从而大大提高治疗效果。在目前的工作中,我们创造了一类新型的 Zn_Mn_CMC_FA_sesamol NC,用于对抗乳腺癌(MDA-MB-231)细胞。为了了解锌(Zn)、锰(Mn)、羧甲基纤维素和叶酸(FA)如何与芝麻酚相互作用,我们使用紫外-可见分光光度计和傅立叶变换红外光谱分析了合成的 NC 的吸收行为。X 射线衍射和动态光散射证实了 NC 的粒度。扫描电子显微镜用于评估这些 NC 的形态特征。光致发光光谱用于分析样品的光学和电子转变分子。除了 MTT 分析外,还使用吖啶橙/溴化乙锭(AO/EtBr)分析活性氧(ROS)、4′,6-二脒基-2-苯基吲哚进行细胞核染色以及流式细胞仪来证实 Zn_Mn_CMC_FA_sesamol NC 对 MDA-MB-231 细胞的凋亡活性。结果表明,与对照细胞相比,处理后的细胞具有明显的细胞毒性,AO/EtBr 诱导细胞凋亡,ROS 生成增加。细胞周期分析表明,NCs 会引发细胞凋亡,并使细胞周期停滞在 G0/G1 期。总之,所创造的 NC 是成功进行癌症分子靶向化疗的多功能平台。
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引用次数: 0
Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents 抗坏血酸介导的硒纳米粒子作为潜在的抗高尿酸血症、抗氧化、抗凝血和溶栓药物
IF 4.3 4区 工程技术 Q1 Engineering Pub Date : 2024-01-01 DOI: 10.1515/gps-2023-0158
Muhammad Aamir Ramzan Siddique, Muhammad Aslam Khan, Syed Ali Imran Bokhari, Muhammad Ismail, Khurshid Ahmad, H. A. Haseeb, Mustafa Mubin Kayani, Suleman Khan, Nafeesa Zahid, Sher Bahadar Khan
Selenium (Se) is an important trace element that is involved in controlling oxidative stress and inflammatory disorders. Gouty arthritis is the inflammation and pain within the joints and tissues caused due to the accumulation of monosodium urate (MSU) crystals. This study aimed to investigate the antigout, antioxidant, anticoagulant, and thrombolytic potential of ascorbic acid-mediated Se nanoparticles (A-SeNPs). Different analytical techniques were used to investigate the formation of A-SeNPs. The antigout potential of the nanoparticles was carried out using MSU crystal dissolution, uric acid (UA) degradation assay, and xanthine oxidase inhibition (XOI). A-SeNPs exhibited excellent antihyperurecemic activity in a concentration-dependent manner. It was observed that at the tested concentration of 20 mg·mL−1, the A-SeNPs demonstrated significant breakage and dissolution of MSU crystals and resulted in UA degradation of 67.76%. Similarly, A-SeNPs resulted in 76% XOI with an excellent IC50 of 140 µg·mL−1. Furthermore, considerable antioxidant activity was noted for the A-SeNPs as evaluated with multiple antioxidant assays. Finally, the NPs were found to have significant anticoagulant and thrombolytic potential. Thus, it was concluded that A-SeNPs have potent antihyperuricemic, antioxidant, anticoagulant, and thrombolytic activities, making them an ideal choice for future biomedical applications.
硒(Se)是一种重要的微量元素,参与控制氧化应激和炎症性疾病。痛风性关节炎是由于单钠尿酸盐(MSU)结晶堆积引起的关节和组织内的炎症和疼痛。本研究旨在探讨抗坏血酸介导的硒纳米粒子(A-SeNPs)的抗痛风、抗氧化、抗凝血和溶栓潜力。研究人员采用了不同的分析技术来研究 A-SeNPs 的形成。使用 MSU 晶体溶解、尿酸(UA)降解测定和黄嘌呤氧化酶抑制(XOI)等方法对纳米粒子的抗痛风潜力进行了研究。A-SeNPs 以浓度依赖的方式表现出卓越的抗高血脂活性。据观察,在 20 毫克/毫升-1 的测试浓度下,A-SeNPs 能显著击碎和溶解 MSU 晶体,使尿酸降解率达到 67.76%。同样,A-SeNPs 的 XOI 为 76%,IC50 为 140 µg-mL-1。此外,通过多种抗氧化试验评估发现,A-SeNPs 具有相当高的抗氧化活性。最后,研究还发现这种 NPs 具有显著的抗凝血和溶栓潜力。因此,A-SeNPs 具有强大的抗高尿酸血症、抗氧化、抗凝血和溶血栓活性,是未来生物医学应用的理想选择。
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Green Processing and Synthesis
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