N-Terminal pro-B-Type natriuretic peptide correlates with prevalence of microvascular complications in emirati adults with type 2 diabetes mellitus

Abstract

Background: Pro-B-type natriuretic peptide (BNP) is a well-known predictor of congestive heart failure. No published data, to our knowledge, are available on the correlation of NT-proBNP with microvascular complications of type 2 diabetes in the Emirati population. Aims and Objectives: We aimed to evaluate the correlation between N-terminal-proBNP (NT-proBNP) and microvascular complications in patients with type 2 diabetes and to evaluate the correlation between NT-proBNP and metabolic parameters in patients with type 2 diabetes. Materials and Methods: This was a cross-sectional study conducted from 1st January 2016 to 31st December 2016. Eligible participants with type 2 diabetes were assessed for the evidence of nephropathy, neuropathy and retinopathy as well as biochemical testing for metabolic parameters. They were divided into two groups based on NT-proBNP level (100 pg/mL). Results: The total number of patients recruited was 236; 39.5% (n = 93) had an NT-proBNP of ≥100 pg/mL (Group A), and 60.5% (n = 143) had an NT-proBNP of <100 pg/mL (Group B). The odds ratio (OR) for patients with NT-proBNP ≥100 (Group A) to develop retinopathy was 2.196 (95% confidence interval [CI] 1.307–3.689, P = 0.003), the OR for Group A to develop neuropathy was 1.607 (95% CI 1.046–2.469, P = 0.031), while the OR for Group A to develop microalbuminuria was 1.082 (95% CI 0.855–1.369, P = 0.515). Conclusion: NT-proBNP is related to the prevalence of microvascular complications in patients with type 2 diabetes mellitus. Using NT-proBNP as a marker can define the population of patients at risk who may benefit from the therapeutic interventions to delay microvascular complication.