Messung des Atemzugvolumens bei Patienten mit Obesitas-Hypoventilations-Syndrom und Opiumabhängigkeit

IF 0.6 Q4 CLINICAL NEUROLOGY Somnologie Pub Date : 2023-11-09 DOI:10.1007/s11818-023-00434-3

Babak Amra, Bahar Behvandi, Forogh Soltaninejad, Mehrzad Salmasi, Awat Feizi, Martin Glos, Ingo Fietze, Thomas Penzel, Matthew Salanitro

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引用次数: 1

Abstract

Abstract Background Both obesity hypoventilation syndrome (OHS) and opium dependence can negatively affect nocturnal respiratory functionality. However, the effects of a combination of the two are relatively unknown. In this study, the tidal volume (VT) of OHS patients with and without opium dependence was estimated by measuring changes in the circumference of the thorax and the abdomen during sleep. Materials and methods This case–control study was performed in Iran, Isfahan. Initially, 20 healthy subjects calibrated the Pneumobelts (Löwenstein Medical Technology GmbH, Hamburg, Germany) by wearing the device and also breathing in and out of a Spirobag. From this, it was possible to estimate the coefficient factors for determining VT based on thoracic and abdominal measures. Subsequently, the study included 55 patients with OHS, who were divided into two groups: opium dependent and non-users. They were then admitted to the sleep lab for a single night of polysomnography (PSG). VT was estimated and then compared between groups. Results In total, there were 24 patients in the opium group and 31 in the non-user control group. All PSG variables were analyzed with independent-sample t -tests and an analysis of covariance was used to adjust for potential confounding variables. The following confounding variables were adjusted: sex, smoking, body mass index, and hypertension. VT values were not significantly different between groups (opium: 772 ± 125.4; non-user: 774 ± 95). Average oxygen saturation values were significantly lower in opium-dependent patients (opium: 86.1 ± 5.5; non-user: 89.1 ± 4.1). All other variables from PSG including chest and abdominal circumference were not significantly different between groups. Conclusion OHS patients with opium dependency showed similar VT levels when compared to non-users with OHS. Due to the rarity of the sample, it was difficult to gather exactly matched pairs. Therefore, it is possible that with a more closely related sample, we might be able to see a difference in VT between groups.

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测量奥氏综合症病人呼吸急促及鸦片依赖程度

背景肥胖低通气综合征(OHS)和鸦片依赖均可对夜间呼吸功能产生负面影响。然而，两者结合的影响相对未知。本研究通过测量睡眠时胸腹围度的变化来估计有鸦片依赖和无鸦片依赖的OHS患者的潮气量(VT)。材料和方法本病例对照研究在伊朗伊斯法罕进行。最初，20名健康受试者通过佩戴该设备并通过吸入和呼出Spirobag来校准气垫(Löwenstein Medical Technology GmbH, Hamburg, Germany)。由此，可以根据胸腹测量来估计决定VT的系数因子。随后，该研究纳入了55名OHS患者，他们被分为两组:鸦片依赖和非使用者。然后他们被送入睡眠实验室进行一晚的多导睡眠描记(PSG)。评估各组间VT并进行比较。结果鸦片治疗组24例，非鸦片治疗组31例。所有PSG变量均采用独立样本t检验进行分析，并采用协方差分析来调整潜在的混杂变量。调整了以下混杂变量:性别、吸烟、体重指数和高血压。各组间VT值无显著差异(鸦片:772±125.4;非用户:774±95)。阿片依赖患者的平均血氧饱和度明显降低(阿片:86.1±5.5;非用户:89.1±4.1)。包括胸围和腹围在内的所有其他PSG变量在组间无显著差异。结论鸦片依赖OHS患者与非鸦片依赖OHS患者的VT水平相似。由于样本的稀缺性，很难收集到完全匹配的配对。因此，有可能通过更密切相关的样本，我们可能能够看到组间VT的差异。

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来源期刊

Somnologie CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

28.60%

发文量

期刊介绍： Die Zeitschrift Somnologie ist das offizielle Organ der Deutschen Gesellschaft für Schlafforschung und Schlafmedizin (DGSM), der Österreichischen Gesellschaft für Schlafmedizin und Schlafforschung (ÖGSM) und der Schweizerischen Gesellschaft für Schlafforschung, Schlafmedizin und Chronobiologie (SGSSC). Auf der Basis von aktuellen, klinisch relevanten Forschungsergebnissen befasst sich die Somnologie mit der Ätiologie, Pathophysiologie, Differentialdiagnostik und Therapie der verschiedenen Schlafstörungen. Eine wissenschaftlich hochqualifizierte Analyse der Ätiologie, Pathophysiologie, Epidemiologie, Diagnose und Therapie verschiedener Schlafstörungen erfordert die Kooperation einer Vielzahl von medizinischen Fachdisziplinen. Durch die Zusammenarbeit von Vertretern aus den Bereichen der Epidemiologie, Humangenetik, HNO, Mund-, Kiefer- und Gesichtschirurgie, Innere Medizin, Pneumologie, Kardiologie, Gastroenterologie, Neurologie, Neurophysiologie, Physiologie, Psychologie, Pädiatrie und Pharmakologie erfüllt die Somnologie die multidisziplinären Anforderungen der Schlafforschung und Schlafmedizin. Besonderes Augenmerk liegt hierbei auch auf methodischen Neuerungen der Biomedizinischen Technik. Neben experimentellen oder klinischen Originalarbeiten und Übersichtsarbeiten werden Empfehlungen, Positionspapiere und Leitlinien der DGSM publiziert. Regelmäßig erscheinende Schwerpunktthemen und die Einrichtung einer CME-Rubrik in der Somnologie erfüllen den Aus- und Weiterbildungsanspruch dieser Zeitschrift und der beteiligten Fachgesellschaften.Auf eine ausgewogene Kombination von wissenschaftlichen Inhalten und praxisnahen Inhalten, die der Aus- und Weiterbildung dienen, wird bei der Zusammenstellung der einzelnen Ausgaben Wert gelegt. Based on current, clinically relevant research results, the journal Somnologie focuses on the etiology, pathophysiology, differential diagnostics and treatment of various sleep disorders.A scientific, comprehensive analysis of the various causes of sleep disorders requires the cooperation of several branches of medicine. Through the collaboration of specialists in the areas of epidemiology, human genetics, ENT, OMF, internal medicine, pneumology, cardiology, gastroenterology, neurology, neurophysiology, physiology, psychology, pediatrics, and pharmacology, Somnologie fulfills the multidisciplinary requirements of sleep research and sleep medicine. Special attention is paid to methodological innovations of biomedical engineering.In addition to experimental and original clinical articles, reviews, case reports, recommendations and guidelines of the DGSM are published. Focus issues and and CME-articles fulfill the continuing education requirements of this journal and the involved professional societies.A balanced combination of scientific content and articles fostering education in sleep medicine is provided in each single issue of Somnologie.