A Rare Case of Seizures Secondary to Proton Pump Inhibitors-Induced Hypomagnesemia

Abstract

Hypomagnesemia is a side effect in patients in treatment with proton pump inhibitors (PPI) for more than one year. It can cause arrhythmias, tetany, seizure, and it can be a life-threatening condition. We describe the case of a 78-year-old man with history of relapsing tonic clonic seizures (TCZ), remote stroke, who presented to emergency department for another episode of TCZ. At blood tests, he had severe hypomagnesemia (0.39 mmol/L). After excluding other causes for hypomagnesaemia, chronic use of PPIs was considered a plausible cause. Therefore, substitutive therapy was initiated to restore blood levels of magnesium, and PPIs were discontinued.