{"title":"Preliminary studies on selection of a vaccine candidate of Classical Swine Fever Virus","authors":"A RAMESH, K KUMANAN","doi":"10.56093/ijans.v93i10.125817","DOIUrl":null,"url":null,"abstract":"Classical swine fever is an economically important and endemic disease of swine in India. Though vaccination is the best way of controlling the disease, currently available vaccines are not very effective. Cell culture adapted local strains of viral pathogens could be a better choice for large scale vaccine production and better immunity. Two local isolates and one lapinized strain of Classical swine fever virus were adapted to PK-15 cells and assessed for their suitability as a vaccine candidate. The CSFV isolate, CSFV-Ind-TN/Veng-09-020–Vn, with a TCID50 titre of 9.5 after 40 continuous passages was found to give better seroconversion, good protection against virulent CSFV challenge and could be a better candidate vaccine strain.","PeriodicalId":13507,"journal":{"name":"Indian Journal of Animal Sciences","volume":"62 1","pages":"0"},"PeriodicalIF":0.2000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Animal Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56093/ijans.v93i10.125817","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
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Abstract
Classical swine fever is an economically important and endemic disease of swine in India. Though vaccination is the best way of controlling the disease, currently available vaccines are not very effective. Cell culture adapted local strains of viral pathogens could be a better choice for large scale vaccine production and better immunity. Two local isolates and one lapinized strain of Classical swine fever virus were adapted to PK-15 cells and assessed for their suitability as a vaccine candidate. The CSFV isolate, CSFV-Ind-TN/Veng-09-020–Vn, with a TCID50 titre of 9.5 after 40 continuous passages was found to give better seroconversion, good protection against virulent CSFV challenge and could be a better candidate vaccine strain.
期刊介绍：
Articles published in The Indian Journal of Animal Sciences encompass a broad range of research topics in animal health and production related to cattle, buffalo, sheep, goat, camel, equines, pig, rabbit, yak, mithun, poultry and fisheries. Studies involving wildlife species and laboratory animal species that address fundamental questions about their biology will also be considered for publication. All manuscripts must present some new development and must be original, timely, significant and scientifically excellent. Papers will be rejected if standards of care of, or procedures performed on animals are not up to those expected of humane veterinary scientists. At a minimum, standards must meet the International Guiding Principles for Biomedical Research involving Animals, as issued by the Council for International Organizations of Medical Sciences. (C.I.O.M.S., c/o WHO, CH 1211 Geneva 27, Switzerland). Articles reporting new animal disease must follow GOI directive as given in detail in Guidelines to Authors.
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