Carbon Dots -A Turn-On Probe for Neurological Disorder

Payel Mukherjee, Manas Chakraborty, Goutam Mukhopadhyay
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Abstract

The creation of novel methods is essential for the early diagnosis and treatment of neurological illnesses (NDs). The blood-brain barrier (BBB), which can prevent substances from accessing the central nervous system, is the most difficult obstacle to overcome in the development of neural medication delivery systems (CNS). For several biological applications, carbon dots (CDs) have emerged as highly outstanding and promising agents, including the treatment of brain tumours, ND, and bioimaging research. Because of their great qualities, they have a lot of potential for a range of scientific disciplines due to their biocompatibility, tiny size, tunable optical properties, photostability, and straightforward fabrication processes. This article's goal is to provide a summary of current CD research and to make recommendations for future work on creating neural drug delivery systems that can penetrate the BBB and reach the central nervous system. The two main subjects of this review are CD toxicity and unique optical properties. For a variety of neurological illnesses, a unique CD-based drug delivery system is designed in detail. This study also explores the possible applications of CDs for neurodegenerative disease therapies and imaging of brain tumours. The final section provides a summary of present CD sensing applications and projected future developments.
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碳点——神经紊乱的开启探针
新方法的创造对于神经系统疾病的早期诊断和治疗至关重要。阻止物质进入中枢神经系统的血脑屏障(BBB)是神经药物传递系统(CNS)开发中最难克服的障碍。对于一些生物应用,碳点(cd)已经成为非常突出和有前途的药物,包括脑肿瘤的治疗,ND和生物成像研究。由于它们的优良品质,由于它们的生物相容性、微小的尺寸、可调的光学特性、光稳定性和简单的制造工艺,它们在一系列科学学科中具有很大的潜力。本文的目的是总结目前的乳糜泻研究,并对未来的工作提出建议,以建立能够穿透血脑屏障并到达中枢神经系统的神经药物传递系统。本综述的两个主要主题是CD的毒性和独特的光学性质。针对多种神经系统疾病,详细设计了一种独特的基于cd的给药系统。本研究还探讨了cd在神经退行性疾病治疗和脑肿瘤成像方面的可能应用。最后一节总结了目前的CD传感应用和预测未来的发展。
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