In vitro anticancer activity of Citrus maxima peel extract on human breast cancer cells

Q4 Biochemistry, Genetics and Molecular Biology Biomedicine (India) Pub Date : 2023-11-08 DOI:10.51248/.v43i5.3412
Flama Monteiro, Shilpa S. Shetty, Ranjitha Acharya, Vijith Vittal Shetty, Suchetha Kumari N.
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Abstract

Introduction and Aim: The alarming rise in breast cancer cases highlights the need for a safer, effective, and more responsive chemoprevention approach for cancer treatment. In contrast to conventional chemotherapeutic medicines, which primarily function as mono-target agents, phytochemicals have been proven to inhibit cancer growth by influencing numerous processes, such as apoptosis and signaling pathways. Citrus maxima (Burm). Merr., frequently identified as pomelo, exhibits a wide range of biological activities, and is utilized extensively in the conventional approach to medicine, and this study focused on anti-cancer properties of Citrus maxima peel extracts. Materials and Methods: The anti-proliferative properties of the Citrus maxima peel extracts and its flavonoid Naringin on the breast cancer cell line was evaluated using the MTT test. The ability of the breast cancer cells to migrate was assessed using a wound healing assay and their capacity to form colonies was assessed using a colony formation assay. Results: The Citrus maxima crude peel extracts and Naringin inhibited the cell proliferation of the breast cancer cell line. The cell viability of breast cancer cells decreased with time after treatment with their corresponding IC50. The colony-formation capacity and migration ability of the cells was also reduced. Conclusion: The examined Citrus maxima crude peel extracts and its flavonoid Naringin showed strong anticancer efficacy by suppressing cell proliferation and could be seen as prospective candidates for upcoming breast cancer therapeutic medications. Extensive research is also needed to fully comprehend the precise mechanism of action of extracts and its components.
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柑桔皮提取物对人乳腺癌细胞的体外抗癌活性研究
简介和目的:乳腺癌病例的惊人增长凸显了对一种更安全、更有效、反应更灵敏的癌症治疗化学预防方法的需求。与主要作为单靶点药物的传统化疗药物相比,植物化学物质已被证明通过影响许多过程(如细胞凋亡和信号通路)来抑制癌症生长。柑橘(棕)。稳定。柑桔,通常被认为是柚子,具有广泛的生物活性,在传统的医学方法中被广泛利用,本研究的重点是柑桔皮提取物的抗癌特性。材料与方法:采用MTT法研究柑桔皮提取物及其类黄酮柚皮苷对乳腺癌细胞株的抗增殖作用。使用伤口愈合试验评估乳腺癌细胞的迁移能力,使用集落形成试验评估其形成集落的能力。结果:柑桔粗皮提取物和柚皮苷对乳腺癌细胞系细胞增殖有抑制作用。治疗后乳腺癌细胞活力随治疗时间的延长而降低,其IC50值也相应降低。细胞的集落形成能力和迁移能力也降低。结论:所研究的大柑橘粗皮提取物及其类黄酮柚皮苷具有较强的抗肿瘤作用,可抑制细胞增殖,有望成为乳腺癌治疗药物的候选药物。还需要进行广泛的研究,以充分了解提取物及其成分的确切作用机制。
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Biomedicine (India)
Biomedicine (India) Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
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