LT Laagland, FC Bach, FM Riemers, G Erdmann, TS Braun, GGH van den Akker, TC Schmitz, LB Creemers, C Sachse, CL Le Maitre, TJM Welting, K Ito, MF Templin, MA Tryfonidou
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引用次数: 0
Abstract
Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the nucleus pulposus shifts from notochordal cells (NCs) to nucleus pulposus cells (NPCs). In previous studies, porcine NC-derived matrix (NCM), containing NC-secreted factors, induced matrix anabolic effects and inhibited pro-inflammatory mediators in NPCs in vitro and in degenerated
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