Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

James Oluwagbamigbe Fajemiroye, Andre Luis Elias Moreira, Célia Regina Malveste Ito, Elson Alves Costa, Rafaella Misael Queiroz, Ogbu John Ihayi, Caroline Vitória Moreira, Rafael Fernandes Costa, Claudia Carneiro Teixeira, Miguel Júnior Sordi Bortolini, Osmar Nascimento Silva
{"title":"Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions","authors":"James Oluwagbamigbe Fajemiroye, Andre Luis Elias Moreira, Célia Regina Malveste Ito, Elson Alves Costa, Rafaella Misael Queiroz, Ogbu John Ihayi, Caroline Vitória Moreira, Rafael Fernandes Costa, Claudia Carneiro Teixeira, Miguel Júnior Sordi Bortolini, Osmar Nascimento Silva","doi":"10.3390/venereology2040013","DOIUrl":null,"url":null,"abstract":"In recent years, the global resurgence of syphilis has posed significant challenges to public health. This sexually transmitted infection, caused by the bacterium Treponema pallidum, can have severe consequences if left untreated, including neurological and cardiovascular complications. Diagnosing syphilis is complex due to its diverse clinical presentations, necessitating a multifaceted approach, including serological, molecular, and direct techniques such as dark-field microscopy. Penicillin remains the primary and effective treatment, but emerging macrolide-resistant strains have spurred investigations into alternative antibiotics. Syphilis vaccine development faces unique hurdles, yet promising strategies are under investigation. Targeted prevention strategies focus on high-risk populations such as men who have sex with men, pregnant women, and individuals with multiple sexual partners. The integration of syphilis services into primary healthcare enhances accessibility, early detection, and treatment. Innovative point-of-care diagnostics offer rapid, sensitive testing, while ongoing vaccine research holds the potential for long-term prevention. Addressing the global burden of syphilis requires a multifaceted approach, encompassing immunological advancements, innovative diagnostics, targeted prevention, and primary healthcare integration. Collaborative efforts between governments, healthcare systems, researchers, and communities are essential to effectively combat syphilis, striving toward a syphilis-free future that promotes better sexual health and overall well-being.","PeriodicalId":75296,"journal":{"name":"Venereology (Basel, Switzerland)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Venereology (Basel, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/venereology2040013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In recent years, the global resurgence of syphilis has posed significant challenges to public health. This sexually transmitted infection, caused by the bacterium Treponema pallidum, can have severe consequences if left untreated, including neurological and cardiovascular complications. Diagnosing syphilis is complex due to its diverse clinical presentations, necessitating a multifaceted approach, including serological, molecular, and direct techniques such as dark-field microscopy. Penicillin remains the primary and effective treatment, but emerging macrolide-resistant strains have spurred investigations into alternative antibiotics. Syphilis vaccine development faces unique hurdles, yet promising strategies are under investigation. Targeted prevention strategies focus on high-risk populations such as men who have sex with men, pregnant women, and individuals with multiple sexual partners. The integration of syphilis services into primary healthcare enhances accessibility, early detection, and treatment. Innovative point-of-care diagnostics offer rapid, sensitive testing, while ongoing vaccine research holds the potential for long-term prevention. Addressing the global burden of syphilis requires a multifaceted approach, encompassing immunological advancements, innovative diagnostics, targeted prevention, and primary healthcare integration. Collaborative efforts between governments, healthcare systems, researchers, and communities are essential to effectively combat syphilis, striving toward a syphilis-free future that promotes better sexual health and overall well-being.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
推进梅毒研究:探索免疫学和药理学干预的新领域
近年来,梅毒在全球的死灰复燃对公共卫生构成了重大挑战。这种由梅毒螺旋体(Treponema pallidum)细菌引起的性传播感染,如果不加以治疗,可能会产生严重后果,包括神经系统和心血管并发症。梅毒的诊断是复杂的,因为其临床表现多样,需要多方面的方法,包括血清学、分子和直接技术,如暗场显微镜。青霉素仍然是主要和有效的治疗方法,但新出现的大环内酯耐药菌株刺激了对替代抗生素的研究。梅毒疫苗的开发面临着独特的障碍,但有希望的策略正在研究中。有针对性的预防战略侧重于高危人群,如男男性行为者、孕妇和有多个性伴侣的个人。将梅毒服务纳入初级卫生保健可提高可及性、早期发现和治疗。创新的即时诊断提供快速、灵敏的检测,而正在进行的疫苗研究具有长期预防的潜力。解决梅毒的全球负担需要采取多方面的方法,包括免疫学进步、创新诊断、有针对性的预防和初级卫生保健整合。政府、卫生保健系统、研究人员和社区之间的合作努力对于有效防治梅毒至关重要,努力实现无梅毒的未来,促进更好的性健康和整体福祉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Screening for HPV-Related Oropharyngeal Cancer in Gay and Bisexual Men: Acceptability and Predicting Possible Use of "Oral Selfies" by Smartphone as a Secondary Prevention Approach. Racial Disparities Associated with Increased Burden of Sexually Transmitted Infections in North Carolina, Southeastern United States Seroprevalence of Human Cytomegalovirus Infection among HIV Patients in Edo State, Southern Nigeria Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions Pangenome Analysis Reveals a High Degree of Genetic Diversity in Gardnerella vaginalis: An In Silico Approach
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1