Comparison of BoLA-DRB3 genetic diversity among polish red and white (PRW) and polish holstein-friesian (PHF) cattle

IF 1.9 4区农林科学 Q1 Veterinary Annals of Animal Science Pub Date : 2023-10-05 DOI:10.2478/aoas-2023-0091

Anna E. Zielak-Steciwko, Tomasz Strzała, Bartosz Luboń, Grzegorz Smołucha, Andrzej Zachwieja, Katarzyna Płoneczko-Janeczka, Krzysztof Rypuła

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Abstract

Abstract Cattle breeding in Poland, including the maintenance of indigenous breeds, is exposed to the occurrence of many diseases of infectious and non-infectious etiologies. Bovine MHC (BoLA)-DRB3 is a highly polymorphic gene that plays an important role in the immune response to antigens. This pilot study aimed to analyze BoLA-DRB3 genetic diversity among Polish Red and White (PRW) and Polish Holstein-Frisian (PHF) cattle. DNA sequencing revealed haplotypes for 48 out of 106 PRW and 10 out of 26 PHF cows. Analysis indicated 42 alleles detected in the PRW breed and 16 in the PHF animals. Interestingly, within the PRW breed three alleles BOLA03100|BoLA-DRB3*001:01|554, BOLA03113|BoLA-DRB3*009:02|270 and BOLA03302|BoLA-DRB3*049:01|236 were observed in 24 cows. Overall, the presented study demonstrated the genetic diversity of the BoLA-DRB3 gene in the indigenous cattle breed Polish Red and White cattle breed for the first time. The acquired results broaden the knowledge of BoLA-DRB3 diversity in cattle, whose genetic variants promote resistance or susceptibility to viral or bacterial diseases.

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波兰红白牛(PRW)和波兰荷斯坦-弗里牛(PHF) BoLA-DRB3遗传多样性的比较

波兰的牛养殖，包括本地品种的维持，暴露于许多传染性和非传染性病因疾病的发生。牛MHC (BoLA)-DRB3是一个高度多态性的基因，在对抗原的免疫反应中起重要作用。本试验旨在分析波兰红白牛(PRW)和波兰荷尔斯坦-弗里斯兰牛(PHF)的BoLA-DRB3遗传多样性。DNA测序结果显示，106头PRW奶牛中有48头单倍体，26头PHF奶牛中有10头单倍体。在PRW品种中检测到42个等位基因，在PHF动物中检测到16个等位基因。有趣的是，在PRW品种中，24头奶牛共检测到BOLA03100|BoLA-DRB3*001:01|554、BOLA03113|BoLA-DRB3*009:02|270和BOLA03302|BoLA-DRB3*049:01|236三个等位基因。总体而言，本研究首次证实了波兰红白牛品种BoLA-DRB3基因的遗传多样性。获得的结果拓宽了对牛BoLA-DRB3多样性的认识，牛的遗传变异促进了对病毒或细菌疾病的抗性或易感性。

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来源期刊

Annals of Animal Science AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

3.80

自引率

5.30%

发文量

138

期刊介绍： Annals of Animal Science accepts original papers and reviews from the different topics of animal science: genetic and farm animal breeding, the biology, physiology and reproduction of animals, animal nutrition and feedstuffs, environment, hygiene and animal production technology, quality of animal origin products, economics and the organization of animal production.