A Review on Drug Delivery Systems Containing Polymer Nanocomposites for Breast Cancer Treatment

IF 11.1 2区化学 Q1 POLYMER SCIENCE Polymer Reviews Pub Date : 2023-10-05 DOI:10.1080/15583724.2023.2262542

Ali Mohammadpour-Haratbar, Yasser Zare, Kyong Yop Rhee

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Abstract

AbstractBreast cancer (BC) is one of the most common malignant cancers among women and the second leading cause of cancer-related deaths. Conventional treatments for BC are effective; however, they have several drawbacks, such as poor bioavailability and substantial side effects. On the other hand, using drug delivery systems (DDSs) have numerous benefits, such as suitable cancer targeting, reduced side effects, and controlled drug release. In recent years, DDSs have become a hotspot for the delivery of anti-BC drugs. The purpose of this review is to explore the progress of recent research on anti-BC drugs and the applications of polymer nanocomposites (PNCs) as DDSs for the treatment of BC. Moreover, this review summarizes important advances in the synthesis, preparation, and application of PNCs, using various nanomaterials and polymers, as nanocarriers for the treatment of BC. The challenges and opportunities associated with future clinical applications of PNCs in the treatment of BC are discussed.Keywords: Polymer nanocompositedrug carriersbreast cancerdrug delivery systemscontrolled release Disclosure statementThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Additional informationFundingThis work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2022R1 A2C1 004437).

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含高分子纳米复合材料的乳腺癌药物传递系统研究进展

摘要乳腺癌(BC)是女性最常见的恶性肿瘤之一，也是癌症相关死亡的第二大原因。对BC的常规治疗是有效的;然而，它们有一些缺点，如生物利用度差和严重的副作用。另一方面，使用药物传递系统(dds)有许多好处，例如合适的癌症靶向，减少副作用和控制药物释放。近年来，dds已成为抗bc药物递送的热点。本文就近年来抗BC药物的研究进展及聚合物纳米复合材料(pnc)作为抗BC药物的应用作一综述。此外，本文综述了利用各种纳米材料和聚合物作为纳米载体处理BC的pnc的合成、制备和应用方面的重要进展。讨论了pnc在BC治疗中未来临床应用的挑战和机遇。关键词:高分子纳米复合药物载体乳腺癌药物传递系统控制释放披露声明作者声明他们没有已知的竞争经济利益或个人关系可能会影响本文所报道的工作。本研究由韩国教育科学技术部国家研究基金(NRF)基础科学研究计划(2022R1 A2C1 004437)资助。

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来源期刊

Polymer Reviews 工程技术-高分子科学

CiteScore

24.80

自引率

0.80%

发文量

审稿时长

6 months

期刊介绍： Polymer Reviews is a reputable publication that focuses on timely issues within the field of macromolecular science and engineering. The journal features high-quality reviews that have been specifically curated by experts in the field. Topics of particular importance include biomedical applications, organic electronics and photonics, nanostructures, micro- and nano-fabrication, biological molecules (such as DNA, proteins, and carbohydrates), polymers for renewable energy and environmental applications, and interdisciplinary intersections involving polymers. The articles in Polymer Reviews fall into two main categories. Some articles offer comprehensive and expansive overviews of a particular subject, while others zero in on the author's own research and situate it within the broader scientific landscape. In both types of articles, the aim is to provide readers with valuable insights and advancements in the field of macromolecular science and engineering.