Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats

Abstract

The central mechanisms of acetylcholine and insulin in nanoparticles via transpalatinal administration to cats were studied using a neuroimaging algorithm, including a software-supported pharmaco-EEG analysis of graphic functions of normalized electrograms. The studied substances were found to exhibit a predominantly depressing action, which begins in the first hours after administration. Liposomal forms of acetylcholine and insulin penetrate the blood-brain barrier and modulate the intracentral relations of the brain, reflected in high-frequency rhythms (mainly γ-rhythms) of the hippocampal region of the brain and associated with the activity of intercalary neurons and pyramidal cells. The substances under study appear to be promising for the prevention and treatment of neuropathies caused, e.g., by geriatric dysfunctions of the cholinergic and insulin signaling systems, as well as for improving memory consolidation and cognitive functions.