Impact of vaccination in the mortality of Colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation

Yina Daniela Benítez Patiño , Luis Carlos Triana , Oscar Mauricio Muñoz Velandia , Viviana Yiset López Ramírez , Laura María Niño Guerra , Santiago Bottia Córdoba
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Abstract

Introduction

Vaccination for SARS-CoV-2 made it possible to reduce severe cases that require invasive mechanical ventilation (IMV) and care in the ICU. However, its impact on severe disease is not clear. The objective was to assess whether adults with severe SARS-CoV-2 pneumonia who required mechanical ventilation had a different clinical behaviour in terms of mortality, depending on their vaccination status.

Methodology

Retrospective cohort study, in adults with severe pneumonia due to SARS-CoV-2 requiring IMV and ICU. Clinical outcomes were evaluated according to vaccination status, controlling for comorbidities.

Results

Two hundred patients (24% vaccinated, age 61 ± 13 years, men 68%) were analysed. The vaccinated had lower CRP at admission, distension pressure and PEEP requirement for IMV. Mortality (43.8 vs 36.8%, P: .335), hospital stay, ICU stay, and time on IMV were similar between groups. Acute kidney injury and haemodialysis requirement (0 vs 9.2%, P: .03) were more frequent in the unvaccinated. There was no association between mortality and receiving at least one dose of vaccination (RR 1.21; CI 95% 0.829–1.774, P: .335).

Conclusions

Vaccination did not impact mortality. However, our data suggest that it may reduce the inflammatory state produced by the disease and the occurrence of acute kidney injury and the requirement for haemodialysis. Future studies will be required to assess the impact of the type of vaccine and/or the number of doses received.

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接种疫苗对哥伦比亚因SARS-CoV-2引起的急性呼吸窘迫综合征需要有创机械通气的成年人死亡率的影响
接种SARS-CoV-2疫苗可以减少需要有创机械通气(IMV)和ICU护理的严重病例。然而,它对严重疾病的影响尚不清楚。目的是评估需要机械通气的成人严重SARS-CoV-2肺炎患者在死亡率方面是否有不同的临床行为,这取决于他们的疫苗接种状况。回顾性队列研究,涉及需要IMV和ICU治疗的成人SARS-CoV-2所致严重肺炎患者。根据疫苗接种情况评估临床结果,控制合并症。分析了200例患者(24%接种疫苗,年龄61±13岁,男性68%)。接种疫苗者入院时CRP、腹胀压和肺活量均较低。两组间死亡率(43.8% vs 36.8%, P: 0.335)、住院时间、ICU住院时间和IMV时间相似。急性肾损伤和血液透析需求在未接种疫苗的人群中更为常见(0比9.2%,P: 0.03)。死亡率与接种至少一剂疫苗之间没有关联(RR 1.21;Ci 95% 0.829-1.774, p: 0.335)。接种疫苗对死亡率没有影响。然而,我们的数据表明,它可能会减少疾病产生的炎症状态和急性肾损伤的发生以及血液透析的需要。今后需要进行研究,以评估疫苗种类和(或)接种剂量的影响。La vacunación para SARS-CoV-2 permitió disminuir casos graves que required de ventilación mecánica invasiva (VMI) y atención en UCI。在禁运期间,没有任何一种克拉罗塞特的影响是严重的。目的:对成人的健康状况进行评估neumonía严重不良的SARS-CoV-2的要求ventilación mecánica健康状况不一致clínico不同的健康状况,según健康状况vacunación。研究小组回顾性研究了7名成年人,他们的研究结果表明,他们对VMI和UCI的几个较差的SARS-CoV-2要求。研究结果表明:clínicos según el estado de vacunación、对照和不良合并症。对200例患者进行分析,其中男性占24%,男性61±13 años,男性68%。Los vacunados tenían menor PCR al ingresso, presión de distensión y requirements to de PEEP para VMI。死亡率(43.8% vs 36.8%, p:0.335)、医院牧场、牧场内UCI、牧场内VMI的死亡率与两组相似。黄酮lesión肾腺癌的发生率高于黄酮hemodiálisis(0比9.2%,p:0.03),黄酮más的发生率高于黄酮más。无hubo asociación中心死亡率与复发性疾病的相关性为vacunación (RR 1.21;IC 95% 0.829-1.774, p: 0.334)。La vacunación no impactó La mortalidad。2008年1月1日,新数据显示,在1个国家/地区(inflamación)的生产资料中,在1个国家/地区(aparición)的生产资料中,在1个国家/地区(lesión)的生产资料中,在1个国家/地区(hemodiálisis)的生产资料中,在1个国家/地区(hemodiálisis)的生产资料中。请参阅requerirán工作室未来的para - evaluation (para - evaluation) / /或número de - dosis recibidas。
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