The Effect of Chrysin-nanocrystal on Oxidative Stress Indices and Histopathological changes in Kidney Tissue of Rats Exposed to Chlorpyrifos

Abstract

aims: The current study looked at the effect of nanocrystal chrysin on the effects of chlorpyrifos on kidney function, as well as the histopathological changes in this tissue and its potential as an antioxidant in the kidneys of adult male rats background: The effect of nanocrystal chrysin on the kidney of rat exposed chlorpyrifos has not fully understood. objective: The safety and efficacy of nanocrystal chrysin was evaluated. method: The rats were randomly divided into six groups of six rats each: 1) a control group treated with corn oil, 2) a group treated with chrysin nanocrystals (5mg/kg), 3) a group treated with chrysin nanocrystals (10mg/kg), 4) a group treated with chrysin nanocrystals (5mg/kg) + chlorpyrifos(30mg/kg), 5) a group treated with chrysin nanocrystals (10mg/kg) +chlorpyrifos(30mg/kg). After the intervention, serum and kidney tissue samples were separated. result: Histology and biochemical factors at the serum level did not reveal any significant changes. Additionally, the morphology of the renal tubules in all groups, including the glomeruli, was normal. There was no inflammation, congestion, necrosis, or degeneration. conclusion: In this study, the serum levels of urea, creatinine, bilirubin, and Alb, which are indicators of kidney function, as well as oxidative stress indices and kidney morphology in animals given doses of 5 mg/kg and 10 mg/kg of chrysin nanocrystals did not change. This study suggests that chrysin nanocrystals with an average diameter of 155 nm may be a safe and efficient antioxidant.