Gas sensors based on nanoparticle-assembled interfaces and their application in breath detection of lung cancer

IF 7.9 2区综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY Cell Reports Physical Science Pub Date : 2023-11-01 DOI:10.1016/j.xcrp.2023.101678

Xinyuan Zhou, Manqing Qi, Kun Li, Zhenjie Xue, Tie Wang

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Abstract

Exhaled breath detection is a noninvasive method to diagnose diseases and is promising in the early screening of lung cancer. However, gas biomarkers of lung cancer within the exhaled breath are various and low content, and the exhaled breath has complex composition and strong fluidity, which puts forward high requirements for the performance of gas sensors. Hence, Wang’s team proposes a strategy for gas sensors based on nanoparticle-assembled interfaces. From the perspective of gas-sensing dynamics of exhaled breath, the microstructure of the sensing interface is designed to enhance their capture and adsorption efficiency via regulating the mass transfer behaviors of gas molecules so as to design high-performance sensors. In addition, from the three levels of cell, organ, and living body, this review summarizes the research strategy and progress of gas biomarkers of lung cancer and comments on the clinical application value of gas biomarkers in the breath detection of lung cancer. Then, this review introduces gas sensors with market application prospects, which promotes the breath detection of lung cancer from theoretical research to clinical application. Finally, breath sensors for lung cancer and prospected in smart homes are summarized.

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基于纳米粒子组装界面的气体传感器及其在肺癌呼吸检测中的应用

呼气检测是一种无创的疾病诊断方法，在肺癌的早期筛查中具有广阔的应用前景。然而，呼出气体中肺癌气体生物标志物种类多、含量低，且呼出气体成分复杂、流动性强，这对气体传感器的性能提出了很高的要求。因此，王的团队提出了一种基于纳米粒子组装界面的气体传感器策略。从呼出气体的气敏动力学角度出发，设计传感界面的微观结构，通过调节气体分子的传质行为来提高其捕获和吸附效率，从而设计出高性能的传感器。此外，从细胞、器官、活体三个层面，综述了肺癌气体生物标志物的研究策略及进展，并对气体生物标志物在肺癌呼吸检测中的临床应用价值进行了评述。然后，本文介绍了具有市场应用前景的气体传感器，促进肺癌呼吸检测从理论研究走向临床应用。最后，对肺癌呼吸传感器及其在智能家居中的应用前景进行了总结。

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来源期刊

Cell Reports Physical Science Energy-Energy (all)

CiteScore

11.40

自引率

2.20%

发文量

388

审稿时长

62 days

期刊介绍： Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.