A Topical Alginate-Based Wound Gel Fixated with Metal-Based Nanoparticles and Tranexamic Acid as a Hemostatic Wound Healing System

IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS BioNanoScience Pub Date : 2023-10-04 DOI:10.1007/s12668-023-01208-9

Xhamla Nqoro, Samson A. Adeyemi, Philemon Ubanako, Derek T. Ndinteh, Pradeep Kumar, Yahya E. Choonara, Blessing A. Aderibigbe

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Abstract

Abstract Wounds are usually accompanied by complications such as excessive bleeding and bacteria invasion. The design of wound dressings that rapidly stop excessive bleeding and inhibit bacterial invasion, is crucial to promoting accelerated wound healing. To meet the abovementioned requirements in wound dressings, topical gels were prepared from sodium alginate (SA) and carbopol. The wound dressings were loaded with an antifibrinolytic agent, tranexamic acid, and a variety of metal-based nanoparticles. The prepared topical gels displayed significant antibacterial efficacy against Gram-negative bacteria and moderate activity against Gram-positive bacterial strains. These gels exhibited good spreadability and viscosity, signifying suitability for skin application, and ease of application. Moreover, the prepared gels showed good cytocompatibility, promoted cell proliferation, and exhibited > 85% wound closure on day 3 compared to the untreated which showed a 38% wound reduction in vitro. Excellent blood clotting absorbance values were observed for the gels compared to the control, showing that they can promote blood clotting. Features presented by the prepared gels reveal that they are promising wound dressings for treating bleeding and infected wounds.

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外用海藻酸盐伤口凝胶固定金属纳米颗粒和氨甲环酸作为止血伤口愈合系统

创面常伴有大量出血、细菌侵袭等并发症。创面敷料的设计能够迅速止血和抑制细菌入侵，对促进伤口加速愈合至关重要。为满足伤口敷料的上述要求，以海藻酸钠(SA)和卡波酚为原料制备外用凝胶。伤口敷料装载了抗纤溶剂、氨甲环酸和各种金属基纳米颗粒。所制备的外用凝胶对革兰氏阴性菌具有显著的抑菌效果，对革兰氏阳性菌具有中等抑菌活性。这些凝胶具有良好的涂抹性和粘度，表明适合皮肤应用，易于使用。此外，制备的凝胶具有良好的细胞相容性，促进细胞增殖，并表现出>与未治疗组相比，第3天伤口愈合了85%伤口减少了38%与对照组相比，观察到凝胶具有良好的凝血吸收值，表明它们可以促进凝血。所制备的凝胶的特征表明，它们是治疗出血和感染伤口的有前途的伤口敷料。

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来源期刊

BioNanoScience MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

5.10

自引率

3.30%

发文量

120

期刊介绍： BioNanoScience is a new field of research that has emerged at the interface of nanoscience and biology, aimed at integration of nano-materials into engineered systems, for new applications in biology and medicine. The aim of BioNanoScience is to provide a forum for the rapidly growing area of bionanoscience, emphasizing the link between structure, properties and processes of nanoscale phenomena in biological and bioinspired structures and materials for a variety of engineered systems. The journal promotes fundamental research in bionanoscience and engineering to advance nanoscience, nanotechnology and engineering, toward application in biology and medicine. This new journal will provide a forum for this interdisciplinary community by publishing highest quality peer-reviewed publications. Methods covered in this journal include experimental (including but not limited to imaging, via SEM/AFM/optical microscopy and tweezers; x-ray scattering and diffraction tools, electrical/magnetic characterizations; design, and synthesis via self-assembly, layer-by-layer, Langmuir films; biotechnology, via recombinant DNA methods, and protein engineering, etc.), theoretical (e.g. statistical mechanics, nanomechanics, quantum mechanics, etc.) and computational (bottom-up multi-scale simulation, first principles methods, supercomputing, etc.) research. Areas of applications of interest include all relevant physical, chemical, and biological phenomena and their engineering into integrated systems: mechanical (e.g. deformation, adhesion, failure), electrical and electronic (e.g. electromechanical stimulation, capacitors, energy storage, batteries), optical (e.g. absorption, luminescence, photochemistry), thermal (e.g. thermomutability, thermal management), biological (e.g. how cells interact with nanomaterials, molecular flaws and defects, biosensing, biological mechanisms s.a. mechanosensing), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue fa ilure), as well as information science (e.g. DNA computing). The journal covers fundamental structural and mechanistic analyses of biological processes at nanoscale and their translation into synthetic applications. Studies of interfaces (e.g. between dissimilar structures, organic-inorganic) are of particular interest. In the area of interface between dissimilar structures, papers are also welcome on hybrid systems, including CMOS integrated circuits embedding organic nanostructures as well as biological components.