Pub Date : 2026-01-01Epub Date: 2026-03-19DOI: 10.1007/s12668-026-02506-8
Francesca Rodino, Myriam Briki, Thierry Buclin, Monia Guidi, Sandro Carrara
Abstract: The increasing demand for precision medicine, particularly in oncology, requires innovative solutions to address patient-specific inter-individual variability in drug response. Therapeutic drug monitoring (TDM) is crucial for optimizing treatment efficacy and minimizing toxic side effects, enabling precise dosage adjustments tailored to the patient's individual metabolic profile. Electrochemical biosensors offer a cost-effective, simple, and portable solution with rapid response times, making them ideal for point-of-care applications. In this work, we propose a novel dual-biosensor platform for TDM, designed to simultaneously detect multiple chemotherapeutic agents-cyclophosphamide, ifosfamide, etoposide, methotrexate, and 5-fluorouracil-for precision oncology. Following real clinical treatment scenarios, the system uses only two working electrodes integrated into a single electrochemical sensing platform, significantly reducing complexity and cost. By integrating MWCNTs with cytochrome P450 enzymes (CYP3A4 and CYP2B6), our platform achieves enhanced electron transfer and substrate specificity, enabling sensitive and selective detection of the five chemotherapeutic drugs, individually and in combination, within clinically relevant ranges. Designed for portability and rapid analysis, this dual-biosensor platform enables real-time, cost-effective drug monitoring at the point-of-care, advancing personalized cancer treatment with greater precision and accessibility.
{"title":"Dual-Biosensor for Five Drugs Detection in Precision Oncology.","authors":"Francesca Rodino, Myriam Briki, Thierry Buclin, Monia Guidi, Sandro Carrara","doi":"10.1007/s12668-026-02506-8","DOIUrl":"https://doi.org/10.1007/s12668-026-02506-8","url":null,"abstract":"<p><strong>Abstract: </strong>The increasing demand for precision medicine, particularly in oncology, requires innovative solutions to address patient-specific inter-individual variability in drug response. Therapeutic drug monitoring (TDM) is crucial for optimizing treatment efficacy and minimizing toxic side effects, enabling precise dosage adjustments tailored to the patient's individual metabolic profile. Electrochemical biosensors offer a cost-effective, simple, and portable solution with rapid response times, making them ideal for point-of-care applications. In this work, we propose a novel dual-biosensor platform for TDM, designed to simultaneously detect multiple chemotherapeutic agents-cyclophosphamide, ifosfamide, etoposide, methotrexate, and 5-fluorouracil-for precision oncology. Following real clinical treatment scenarios, the system uses only two working electrodes integrated into a single electrochemical sensing platform, significantly reducing complexity and cost. By integrating MWCNTs with cytochrome P450 enzymes (CYP3A4 and CYP2B6), our platform achieves enhanced electron transfer and substrate specificity, enabling sensitive and selective detection of the five chemotherapeutic drugs, individually and in combination, within clinically relevant ranges. Designed for portability and rapid analysis, this dual-biosensor platform enables real-time, cost-effective drug monitoring at the point-of-care, advancing personalized cancer treatment with greater precision and accessibility.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"16 4","pages":"258"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-12-05DOI: 10.1007/s12668-024-01678-5
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky
An important part of studying living systems is figuring out the complicated steps that lead to order from chaos. Spontaneous oscillations are a key part of self-organisation in many biological and chemical networks, including kombucha and proteinoids. This study examines the spontaneous oscillations in kombucha and proteinoids, specifically exploring their potential connection to the origin of life. As a community of bacteria and yeast work together, kombucha shows remarkable spontaneous oscillations in its biochemical parts. This system can keep a dynamic balance and organise itself thanks to metabolic processes and complex chemical reactions. Similarly, proteinoids, which may have been primitive forms of proteins, undergo spontaneous fluctuations in their structure and function periodically. Because these oscillations happen on their own, they may play a very important part in the development of early life forms. This paper highlights the fundamental principles governing the transition from chaos to order in living systems by examining the key factors that influence the frequency and characteristics of spontaneous oscillations in kombucha and proteinoids. Looking into these rhythms not only helps us understand where life came from but also shows us ways to make self-organising networks in synthetic biology and biotechnology. There is significant discussion over the emergence of biological order from chemical disorder. This article contributes to the ongoing discussion by examining at the theoretical basis, experimental proof, and implications of spontaneous oscillations. The results make it clear that random oscillations are an important part of the change from nonliving to living matter. They also give us important information about what life is all about.
{"title":"On Emergence of Spontaneous Oscillations in Kombucha and Proteinoids.","authors":"Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky","doi":"10.1007/s12668-024-01678-5","DOIUrl":"10.1007/s12668-024-01678-5","url":null,"abstract":"<p><p>An important part of studying living systems is figuring out the complicated steps that lead to order from chaos. Spontaneous oscillations are a key part of self-organisation in many biological and chemical networks, including kombucha and proteinoids. This study examines the spontaneous oscillations in kombucha and proteinoids, specifically exploring their potential connection to the origin of life. As a community of bacteria and yeast work together, kombucha shows remarkable spontaneous oscillations in its biochemical parts. This system can keep a dynamic balance and organise itself thanks to metabolic processes and complex chemical reactions. Similarly, proteinoids, which may have been primitive forms of proteins, undergo spontaneous fluctuations in their structure and function periodically. Because these oscillations happen on their own, they may play a very important part in the development of early life forms. This paper highlights the fundamental principles governing the transition from chaos to order in living systems by examining the key factors that influence the frequency and characteristics of spontaneous oscillations in kombucha and proteinoids. Looking into these rhythms not only helps us understand where life came from but also shows us ways to make self-organising networks in synthetic biology and biotechnology. There is significant discussion over the emergence of biological order from chemical disorder. This article contributes to the ongoing discussion by examining at the theoretical basis, experimental proof, and implications of spontaneous oscillations. The results make it clear that random oscillations are an important part of the change from nonliving to living matter. They also give us important information about what life is all about.</p>","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"15 1","pages":"65"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.1007/s12668-023-01288-7
A. Bhat, Gaurav Gupta, Muhammad Afzal, Riya Thapa, Haider Ali, Safar M. Alqahtani, W. Almalki, Imran Kazmi, S. Alzarea, Shakir Saleem, Vetriselvan Subramaniyan
{"title":"Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review","authors":"A. Bhat, Gaurav Gupta, Muhammad Afzal, Riya Thapa, Haider Ali, Safar M. Alqahtani, W. Almalki, Imran Kazmi, S. Alzarea, Shakir Saleem, Vetriselvan Subramaniyan","doi":"10.1007/s12668-023-01288-7","DOIUrl":"https://doi.org/10.1007/s12668-023-01288-7","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"78 17","pages":"1-19"},"PeriodicalIF":3.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.1007/s12668-023-01285-w
Velmurugan Sekar, Jayaraman Narenkumar, A. Rajasekar, Amutha Santhanam, P. Velmurugan, Mohammad Mansoob Khan, Nagaraj Basavegowda
{"title":"HAP-Based Nanocomposite and Vitamin C for Sustained Drug Delivery of Amoxicillin","authors":"Velmurugan Sekar, Jayaraman Narenkumar, A. Rajasekar, Amutha Santhanam, P. Velmurugan, Mohammad Mansoob Khan, Nagaraj Basavegowda","doi":"10.1007/s12668-023-01285-w","DOIUrl":"https://doi.org/10.1007/s12668-023-01285-w","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"50 28","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.1007/s12668-023-01289-6
Manoswini Manoswini, Madhuchhanda Mohanty, Amrito Ghosh Majumdar, B. R. Sahu, P. Mohanty
{"title":"Extraction and Characterizations of Viral Protein Particles: A Methodological Study","authors":"Manoswini Manoswini, Madhuchhanda Mohanty, Amrito Ghosh Majumdar, B. R. Sahu, P. Mohanty","doi":"10.1007/s12668-023-01289-6","DOIUrl":"https://doi.org/10.1007/s12668-023-01289-6","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"49 35","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.1007/s12668-023-01265-0
Nazia Shahmir, Muhammad Ramzan, Javaria Akram, S. Kadry, Saad Alshahrani, Shuguang Li
{"title":"Peristaltic Flow of Ethylene Glycol and Water Mixture-Based Hybrid Nanofluid in an Asymmetric Channel","authors":"Nazia Shahmir, Muhammad Ramzan, Javaria Akram, S. Kadry, Saad Alshahrani, Shuguang Li","doi":"10.1007/s12668-023-01265-0","DOIUrl":"https://doi.org/10.1007/s12668-023-01265-0","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":" 19","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-29DOI: 10.1007/s12668-023-01279-8
Ashish Mishra, Gunjan Pathak, Alok Kumar
{"title":"Computational Analysis of Bioconvection of MoS2-SiO2-GO/H2O Ternary Hybrid Nanofluid Containing Gyrotactic Microorganisms over an Exponentially Stretching Sheet with Chemical Reaction","authors":"Ashish Mishra, Gunjan Pathak, Alok Kumar","doi":"10.1007/s12668-023-01279-8","DOIUrl":"https://doi.org/10.1007/s12668-023-01279-8","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":" 32","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139143292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-29DOI: 10.1007/s12668-023-01264-1
Y. Ōnishi, Rui-Cheng Ji, Takashi Kobayashi, M. Onishi, Masaaki Mizuno, Jun Yoshida, Naoji Kubota, Yuki Eshita
{"title":"Soliton-Based Signaling Communication and Supermolecular Nano-complex by DDMC/PTX in Tumor Microenvironment","authors":"Y. Ōnishi, Rui-Cheng Ji, Takashi Kobayashi, M. Onishi, Masaaki Mizuno, Jun Yoshida, Naoji Kubota, Yuki Eshita","doi":"10.1007/s12668-023-01264-1","DOIUrl":"https://doi.org/10.1007/s12668-023-01264-1","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"28 52","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139147445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-29DOI: 10.1007/s12668-023-01278-9
Sarika Hinge, Arun Banpurkar, Gauri Kulkarni
{"title":"Probing the Interaction Between Red Blood Cells and Gold Nanoparticles by Optical Tweezer","authors":"Sarika Hinge, Arun Banpurkar, Gauri Kulkarni","doi":"10.1007/s12668-023-01278-9","DOIUrl":"https://doi.org/10.1007/s12668-023-01278-9","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":" 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139144468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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