Effect and Safety of Amoxicillin-Clavulanate Potassium and Ceftriaxone Combined with Pulmonary Physical Therapy on Neonatal Pneumonia

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI:10.36468/pharmaceutical-sciences.spl.731
Jing Li, Di Zhang, Wenxiu Yao
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Abstract

The main objective of this study was to determine the effect, safety and intestinal microecology of amoxicillin-clavulanate potassium, ceftriaxone combined with pulmonary physical therapy on neonatal pneumonia. A total of 180 neonatal pneumonia patients in our hospital were studied and divided into research group (n=90) and control group (n=90). The control group was treated with amoxicillin-clavulanate potassium and ceftriaxone and the study group was treated with pulmonary physiotherapy on the basis of control group. The treatment cycle was 7 d. The two groups were compared with total response rate, symptom resolution time, lung function index, inflammatory factor index, adverse reactions and the number of major probiotics in the intestine. The total effective rate of the research group was significantly higher than that of the control group, the symptom disappearance time of the research group was shorter than that of the control group and the lung function index was better than that of the control group. The inflammatory factor index, the incidence of adverse reactions was lower than that of the control group and the main probiotics in the intestinal tract of the research group was more than that of the control group (p<0.05). For neonatal pneumonia, on the basis of amoxicillin-clavulanate potassium and ceftriaxone, supplemented with pulmonary physical therapy, the effect is better, the safety is high and it can improve the lung function level of patients, reduce the level of inflammatory factors and balance the gut microbiome.
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阿莫西林-克拉维酸钾联合头孢曲松联合肺部物理治疗新生儿肺炎的疗效及安全性
本研究的主要目的是确定阿莫西林-克拉维酸钾、头孢曲松联合肺部物理治疗对新生儿肺炎的疗效、安全性和肠道微生态。对我院180例新生儿肺炎患者进行研究,分为研究组(n=90)和对照组(n=90)。对照组给予阿莫西林-克拉维酸钾联合头孢曲松治疗,研究组在对照组的基础上给予肺部物理治疗。治疗周期为7 d。比较两组患者总有效率、症状缓解时间、肺功能指数、炎症因子指数、不良反应及肠道主要益生菌数量。研究组总有效率显著高于对照组,症状消失时间短于对照组,肺功能指标好于对照组。研究组炎症因子指数、不良反应发生率均低于对照组,肠道主要益生菌数量均高于对照组(p<0.05)。对于新生儿肺炎,在阿莫西林-克拉维酸钾和头孢曲松的基础上,辅以肺部物理治疗,效果更好,安全性高,可改善患者肺功能水平,降低炎症因子水平,平衡肠道微生物群。
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期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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