Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1084
M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi
caused notable reduction in body weight of high fat diet rats. Compound 4b i.e. (Z)-3-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylprop-2-en-1-one has ability to reduce body weight and improve lipid profile in rats and requires further studies to establish its safety and efficacy in preclinical and clinical subjects.
{"title":"Synthesis, Cannabinoid Receptor Targeted Molecular Docking of Some New Pyrazole Derivatives as Hypolipidemic and Anti- Obesity Agents","authors":"M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi","doi":"10.36468/pharmaceutical-sciences.1084","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1084","url":null,"abstract":"caused notable reduction in body weight of high fat diet rats. Compound 4b i.e. (Z)-3-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylprop-2-en-1-one has ability to reduce body weight and improve lipid profile in rats and requires further studies to establish its safety and efficacy in preclinical and clinical subjects.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1125
A. Chowhan, B. Ghosh, T. Giri
{"title":"Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release","authors":"A. Chowhan, B. Ghosh, T. Giri","doi":"10.36468/pharmaceutical-sciences.1125","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1125","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1133
Swati Ughade, R. D. Bawankar, D. R. Mundhada
{"title":"Nifedipine Gastro Retentive Drug Delivery System: Formulation Characterization and Evaluation","authors":"Swati Ughade, R. D. Bawankar, D. R. Mundhada","doi":"10.36468/pharmaceutical-sciences.1133","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1133","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1146
K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula
{"title":"Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines","authors":"K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula","doi":"10.36468/pharmaceutical-sciences.1146","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1146","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1147
J. Kim, Ildoo Kim
Kim et al. : Arsenic Compounds Attenuate 3-Methylcholanthrene-Induced Cytotoxicity As complex mixtures of carcinogenic metalloids, arsenic compounds have been reported to possess anticytotoxic and antitumor effects. In this study, we evaluated the in vitro protective effects of arsenic compounds tetraarsenic oxide and arsenic trioxide against 3-methylcholanthrene-induced toxicity in human keratinocytes. Human keratinocytes were treated with varying concentrations of arsenic compounds alone or in combination with 3-methylcholanthrene. Treatment with arsenic compounds did not significantly affect cell viability, whereas, 3-methylcholanthrene significantly reduced the viability of human keratinocytes. Furthermore, both tetraarsenic oxide and arsenic trioxide decreased the expression of cytochrome P4501A1 at messenger ribonucleic acid and protein levels in human keratinocytes cells treated with 3-methylcholanthrene. In addition, these arsenic compounds increased the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1, which was shown to be inhibited by 3-methylcholanthrene treatment. Together, these findings suggest that tetraarsenic oxide and tetraarsenic oxide significantly inhibit 3-methylcholanthrene-induced cytotoxicity in human keratinocytes by decreasing the expression of cytochrome P4501A1 and increasing the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1. Additionally, tetraarsenic oxide was found to be more effective than arsenic trioxide against 3-methylcholanthrene-induced cytotoxicity in vitro .
{"title":"Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocytes","authors":"J. Kim, Ildoo Kim","doi":"10.36468/pharmaceutical-sciences.1147","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1147","url":null,"abstract":"Kim et al. : Arsenic Compounds Attenuate 3-Methylcholanthrene-Induced Cytotoxicity As complex mixtures of carcinogenic metalloids, arsenic compounds have been reported to possess anticytotoxic and antitumor effects. In this study, we evaluated the in vitro protective effects of arsenic compounds tetraarsenic oxide and arsenic trioxide against 3-methylcholanthrene-induced toxicity in human keratinocytes. Human keratinocytes were treated with varying concentrations of arsenic compounds alone or in combination with 3-methylcholanthrene. Treatment with arsenic compounds did not significantly affect cell viability, whereas, 3-methylcholanthrene significantly reduced the viability of human keratinocytes. Furthermore, both tetraarsenic oxide and arsenic trioxide decreased the expression of cytochrome P4501A1 at messenger ribonucleic acid and protein levels in human keratinocytes cells treated with 3-methylcholanthrene. In addition, these arsenic compounds increased the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1, which was shown to be inhibited by 3-methylcholanthrene treatment. Together, these findings suggest that tetraarsenic oxide and tetraarsenic oxide significantly inhibit 3-methylcholanthrene-induced cytotoxicity in human keratinocytes by decreasing the expression of cytochrome P4501A1 and increasing the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1. Additionally, tetraarsenic oxide was found to be more effective than arsenic trioxide against 3-methylcholanthrene-induced cytotoxicity in vitro .","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.673
M. He, Yalin Chen, Longwu Yu
He et
他等
{"title":"Application of Alveolar Lavage Fluid Second-Generation Sequencing in the Treatment of Severe Pneumonia","authors":"M. He, Yalin Chen, Longwu Yu","doi":"10.36468/pharmaceutical-sciences.spl.673","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.673","url":null,"abstract":"He et","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.675
Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu
:
：
{"title":"Clinical Efficacy and Safety Analysis of Glucocorticoids plus Immunosuppressive Agents for Systemic Lupus Erythematosus and its Influence on N-Glycan","authors":"Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu","doi":"10.36468/pharmaceutical-sciences.spl.675","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.675","url":null,"abstract":":","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.679
Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song
with type 2 diabetes mellitus combined with renal cell carcinoma are closely related to poor prognosis. Based on this, the individualized early warning model established by synthetic minority oversampling technique oversampling algorithm is beneficial to patients with high risk of poor prognosis early identification.
{"title":"Preliminary Construction of Prognostic Risk Early Warning Model for Renal Cell Carcinoma with Type 2 Diabetes Mellitus Based on SMOTE Algorithm","authors":"Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song","doi":"10.36468/pharmaceutical-sciences.spl.679","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.679","url":null,"abstract":"with type 2 diabetes mellitus combined with renal cell carcinoma are closely related to poor prognosis. Based on this, the individualized early warning model established by synthetic minority oversampling technique oversampling algorithm is beneficial to patients with high risk of poor prognosis early identification.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.606
Dan Xu, Xiuwen Ni, Tao Chen
{"title":"The Interference of Monoclonal Anti-Cluster of Differentiation 47 on Transfusion Compatibility Testing","authors":"Dan Xu, Xiuwen Ni, Tao Chen","doi":"10.36468/pharmaceutical-sciences.spl.606","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.606","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.608
Y. W. Li, Feng He, Shuang Liu, Yu Zhang, Ling Li, Bin Wang, Lan Lan, Zheyi Pan
axis could modulate tumor growth and survival time in vivo . Collectively, these data initiated a C-C motif ligand 21/C-C motif chemokine receptor 7-Janus kinase 2/signal transducer and activator of transcription 3 signaling for non-small cell lung cancer patients with brain metastasis, which shed various beneficial insights for future study.
{"title":"C-C Motif Ligand 21/C-C Motif Chemokine Receptor 7 Modulated Tumor Properties for Non-Small Cell Lung Cancer Brain Metastasis Patients","authors":"Y. W. Li, Feng He, Shuang Liu, Yu Zhang, Ling Li, Bin Wang, Lan Lan, Zheyi Pan","doi":"10.36468/pharmaceutical-sciences.spl.608","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.608","url":null,"abstract":"axis could modulate tumor growth and survival time in vivo . Collectively, these data initiated a C-C motif ligand 21/C-C motif chemokine receptor 7-Janus kinase 2/signal transducer and activator of transcription 3 signaling for non-small cell lung cancer patients with brain metastasis, which shed various beneficial insights for future study.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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