Abigail L. Barker, Yosef Geva, Eyal Simonovsky, Netta Shemesh, Yael Phillip, Ifat Shub, Franck E. Dayan
{"title":"Protoporphyrinogen oxidase inhibitors discovered by Artificial Intelligence platform","authors":"Abigail L. Barker, Yosef Geva, Eyal Simonovsky, Netta Shemesh, Yael Phillip, Ifat Shub, Franck E. Dayan","doi":"10.51694/advweedsci/2023;41:00011","DOIUrl":null,"url":null,"abstract":"Background Weed control is essential in modern agriculture, though it has become more difficult with the emergence of resistance to most current herbicides and the slow registration process for new compounds. Objective Identify herbicide candidates using an innovative artificial intelligence algorithm that takes into effect biological parameters with the goal of reducing research and development time of new herbicides. Results We describe the discovery of 4-chloro-2-pentenamides as novel inhibitors of protoporphyrinogen oxidase (PPO), a known herbicide target site, by [...]","PeriodicalId":29845,"journal":{"name":"Advances in Weed Science","volume":"27 1","pages":"0"},"PeriodicalIF":1.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Weed Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51694/advweedsci/2023;41:00011","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background Weed control is essential in modern agriculture, though it has become more difficult with the emergence of resistance to most current herbicides and the slow registration process for new compounds. Objective Identify herbicide candidates using an innovative artificial intelligence algorithm that takes into effect biological parameters with the goal of reducing research and development time of new herbicides. Results We describe the discovery of 4-chloro-2-pentenamides as novel inhibitors of protoporphyrinogen oxidase (PPO), a known herbicide target site, by [...]
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