{"title":"Tolerancia central de las células T, ¿qué hay de nuevo?","authors":"","doi":"10.1016/j.rcreu.2023.08.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Random somatic recombination of T<!--> <!-->cell receptors facilitates the variability of response to foreign antigens. Then, central tolerance occurs, a mechanism designed to avoid exit of autoreactive T<!--> <!-->cells from the thymus. However, failures in this process can induce the appearance of autoimmunity.</div></div><div><h3>Materials and methods</h3><div>This narrative review was conducted through a literature search focused on describing relevant and recent concepts of central tolerance of T<!--> <!-->cells.</div></div><div><h3>Results</h3><div>Multiple cell groups are part of the thymic microenvironment, among them, thymic epithelial cells are responsible for directing development of thymocytes, especially medullary thymic epithelial cells that direct the negative selection process.</div></div><div><h3>Conclusions</h3><div>Factors that affect thymocytes, the thymic microenvironment, or interaction between them, can lead to development of immunodeficiencies and/or autoimmunity.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Colombiana de Reumatologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0121812323000634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Health Professions","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
Random somatic recombination of T cell receptors facilitates the variability of response to foreign antigens. Then, central tolerance occurs, a mechanism designed to avoid exit of autoreactive T cells from the thymus. However, failures in this process can induce the appearance of autoimmunity.
Materials and methods
This narrative review was conducted through a literature search focused on describing relevant and recent concepts of central tolerance of T cells.
Results
Multiple cell groups are part of the thymic microenvironment, among them, thymic epithelial cells are responsible for directing development of thymocytes, especially medullary thymic epithelial cells that direct the negative selection process.
Conclusions
Factors that affect thymocytes, the thymic microenvironment, or interaction between them, can lead to development of immunodeficiencies and/or autoimmunity.
导言T细胞受体的随机体细胞重组促进了对外来抗原反应的可变性。然后，中枢耐受发生，这是一种旨在避免自体反应性 T 细胞从胸腺退出的机制。材料与方法本综述通过文献检索进行，重点是描述 T 细胞中枢耐受的相关最新概念。结果胸腺微环境中有多个细胞群，其中胸腺上皮细胞负责指导胸腺细胞的发育，尤其是髓质胸腺上皮细胞指导负选择过程。
期刊介绍：
The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.
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