Uncovering the Biological Applications of Cinnamic Acid Derivatives: A Patent Review

IF 1.2 4区医学 Q4 CHEMISTRY, MEDICINAL Letters in Drug Design & Discovery Pub Date : 2023-10-20 DOI:10.2174/0115701808273623231009074241

Ricardo Silva Porto, Viviane Amaral Porto

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Abstract

Background: Cinnamic acid, derived from Cinnamomum cassia, is a natural compound known for its wide-ranging therapeutic properties and minimal toxicity. Extensive research has demonstrated the diverse biological activities displayed by cinnamic acid derivatives, encompassing their potential as agents against cancer, diabetes, microbial infections, tuberculosis, malaria, and more. Objective: This review aims to provide an overview of the latest applications detailing the biological activity of cinnamic acid derivatives, as documented in patents. Methods: The published patent data underwent a prior screening and selection process based on their relevance and primary focus: the biological activities of cinnamic acid derivatives as potential drugs. Espacenet, USPTO, and Google Patents were used for this selection. Results: Cinnamic acid derivatives demonstrate a range of activities, including anticancer, antibacterial, anti-inflammatory, analgesic, anticholinesterase, and other properties. These biological activities were investigated across different derivatives, emphasizing their pharmacological potential when compared to reference compounds. Conclusions: Despite several patents have explored the biological properties of cinnamic acid derivatives, there has been a lack of a comprehensive review dedicated to this subject. Accordingly, this review aims to facilitate the discovery of new and diverse potential drugs with various therapeutic profiles.

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揭示肉桂酸衍生物的生物学应用:专利综述

背景:肉桂酸是从肉桂中提取的，是一种天然化合物，以其广泛的治疗特性和最小的毒性而闻名。广泛的研究表明，肉桂酸衍生物显示出多种生物活性，包括它们作为抗癌、糖尿病、微生物感染、结核病、疟疾等药物的潜力。目的:本文综述了肉桂酸衍生物的最新应用，详细介绍了专利文件中的生物活性。方法:对已发表的专利资料根据其相关性和主要关注点:肉桂酸衍生物作为潜在药物的生物活性，进行事先筛选和选择过程。Espacenet, USPTO和Google专利被用于此选择。结果:肉桂酸衍生物具有抗癌、抗菌、抗炎、镇痛、抗胆碱酯酶等多种活性。这些生物活性在不同的衍生物中进行了研究，强调了它们与对照化合物相比的药理潜力。结论:尽管一些专利已经探索了肉桂酸衍生物的生物学特性，但一直缺乏专门针对这一主题的全面审查。因此，本综述旨在促进发现具有不同治疗概况的新的和不同的潜在药物。

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来源期刊

Letters in Drug Design & Discovery 医学-医药化学

CiteScore

1.80

自引率

10.00%

发文量

245

审稿时长

3 months

期刊介绍： Aims & Scope Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.