Neurocognitive Functions in Opioid Dependence: Comparisons Between Opioid Categories

IF 1.2 4区社会学 Q4 SUBSTANCE ABUSE Journal of Drug Issues Pub Date : 2023-05-30 DOI:10.1177/00220426231179208

Abhishek Ghosh, Alka Shaktan, Abhishek Verma, Ritu Nehra, Debasish Basu, Devender K Rana, Chirag K Ahuja, Manish Modi, Paramjit Singh

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Abstract

We examined the differences in neurocognitive functions in individuals dependent on heroin ( n = 120), pharmaceutical ( n = 52), and natural opioids ( n = 66) and compared with healthy controls (HC, n = 94). We estimated independent effects of the opioid groups on cognitive tests, adjusted for effect modifiers. Pharmaceutical opioid dependent group performed worse than HC in Wisconsin Card Sorting Test in conceptual level response and trials to complete first category. Pharmaceutical and heroin groups had higher error scores than HC in verbal and visual N-Back Tests (NBTs). There was no significant difference between pharmaceutical and heroin groups, but both had higher error scores than the natural opioid users in NBTs. Time to complete Trail Making- A test was higher in pharmaceutical than in natural opioid group. The natural opioid group required more trials than HC to complete the first category. Pharmaceutical opioid group had worst cognitive impairment. Cognitive functions are relatively spared in natural opioid-dependent group.

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阿片类药物依赖的神经认知功能:阿片类药物类别的比较

我们检测了依赖海洛因(n = 120)、药物(n = 52)和天然阿片类药物(n = 66)的个体在神经认知功能上的差异，并与健康对照(HC, n = 94)进行了比较。我们估计了阿片类药物组对认知测试的独立影响，并根据影响调节剂进行了调整。药物类阿片依赖组在威斯康星卡片分类测验的概念水平反应和完成第一类的试验中表现差于HC。药物组和海洛因组在言语和视觉N-Back测试中的错误得分高于HC组。药物组和海洛因组之间的错误评分没有显著差异，但两者的错误评分都高于天然阿片类药物使用者。完成Trail Making- A测试的时间，药物组高于天然阿片类药物组。天然阿片类药物组比HC需要更多的试验来完成第一类。阿片类药物组认知功能障碍最严重。天然阿片类药物依赖组的认知功能相对完好。

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来源期刊

Journal of Drug Issues SUBSTANCE ABUSE-

CiteScore

3.00

自引率

11.80%

发文量

期刊介绍： The Journal of Drug Issues (JDI) was incorporated as a nonprofit entity in the State of Florida in 1971. In 1996, JDI was transferred to the Florida State University College of Criminology and Criminal Justice, and the Richard L. Rachin Endowment was established to support its continued publication. Since its inception, JDI has been dedicated to providing a professional and scholarly forum centered on the national and international problems associated with drugs, especially illicit drugs. It is a refereed publication with international contributors and subscribers. As a leader in its field, JDI is an instrument widely used by research scholars, public policy analysts, and those involved in the day-to-day struggle against the problem of drug abuse.