{"title":"W35. INVESTIGATION OF RELATIONSHIPS BETWEEN INTERNALIZING, EXTERNALIZING, AND RISKY SEXUAL BEHAVIOR: A GENETICALLY-INFORMATIVE SAMPLE","authors":"Katie Paulich, Michael Stallings","doi":"10.1016/j.euroneuro.2023.08.225","DOIUrl":null,"url":null,"abstract":"Risky sexual behavior (RSB) has been linked to substance abuse, externalizing problems, and internalizing problems, with previous research documenting significant phenotypic and genetic correlations between RSB and these other factors of interest. Potential sex differences in those relationships have also been examined previously; the authors’ prior research suggested a stronger correlation between RSB and internalizing problems alone in females. The current study uses a Colorado twin sample in addition to biometrical methods to expand on previous findings to investigate whether the association between RSB and internalizing problems persists when externalizing problems are accounted for, and whether unique genetic influences underlie the associations between the three latent factors. We also investigate whether sex differences in the three-variable latent model replicate those demonstrated previously. Specifically, we hypothesize that the association between RSB and internalizing problems will be stronger in females than in males, whereas the association between RSB and externalizing problems will be stronger in males. Final results pending. Our results could have important implications both to the understanding of RSB as a construct, as well as to the public health sector. Additional discussion pending.","PeriodicalId":12049,"journal":{"name":"European Neuropsychopharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":6.7000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Neuropsychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.euroneuro.2023.08.225","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Risky sexual behavior (RSB) has been linked to substance abuse, externalizing problems, and internalizing problems, with previous research documenting significant phenotypic and genetic correlations between RSB and these other factors of interest. Potential sex differences in those relationships have also been examined previously; the authors’ prior research suggested a stronger correlation between RSB and internalizing problems alone in females. The current study uses a Colorado twin sample in addition to biometrical methods to expand on previous findings to investigate whether the association between RSB and internalizing problems persists when externalizing problems are accounted for, and whether unique genetic influences underlie the associations between the three latent factors. We also investigate whether sex differences in the three-variable latent model replicate those demonstrated previously. Specifically, we hypothesize that the association between RSB and internalizing problems will be stronger in females than in males, whereas the association between RSB and externalizing problems will be stronger in males. Final results pending. Our results could have important implications both to the understanding of RSB as a construct, as well as to the public health sector. Additional discussion pending.
期刊介绍:
European Neuropsychopharmacology is the official publication of the European College of Neuropsychopharmacology (ECNP). In accordance with the mission of the College, the journal focuses on clinical and basic science contributions that advance our understanding of brain function and human behaviour and enable translation into improved treatments and enhanced public health impact in psychiatry. Recent years have been characterized by exciting advances in basic knowledge and available experimental techniques in neuroscience and genomics. However, clinical translation of these findings has not been as rapid. The journal aims to narrow this gap by promoting findings that are expected to have a major impact on both our understanding of the biological bases of mental disorders and the development and improvement of treatments, ideally paving the way for prevention and recovery.