W35. INVESTIGATION OF RELATIONSHIPS BETWEEN INTERNALIZING, EXTERNALIZING, AND RISKY SEXUAL BEHAVIOR: A GENETICALLY-INFORMATIVE SAMPLE

IF 6.7 2区 医学 Q1 CLINICAL NEUROLOGY European Neuropsychopharmacology Pub Date : 2023-10-01 DOI:10.1016/j.euroneuro.2023.08.225
Katie Paulich, Michael Stallings
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引用次数: 0

Abstract

Risky sexual behavior (RSB) has been linked to substance abuse, externalizing problems, and internalizing problems, with previous research documenting significant phenotypic and genetic correlations between RSB and these other factors of interest. Potential sex differences in those relationships have also been examined previously; the authors’ prior research suggested a stronger correlation between RSB and internalizing problems alone in females. The current study uses a Colorado twin sample in addition to biometrical methods to expand on previous findings to investigate whether the association between RSB and internalizing problems persists when externalizing problems are accounted for, and whether unique genetic influences underlie the associations between the three latent factors. We also investigate whether sex differences in the three-variable latent model replicate those demonstrated previously. Specifically, we hypothesize that the association between RSB and internalizing problems will be stronger in females than in males, whereas the association between RSB and externalizing problems will be stronger in males. Final results pending. Our results could have important implications both to the understanding of RSB as a construct, as well as to the public health sector. Additional discussion pending.
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W35。内化、外化和危险性行为之间关系的调查:一个基因信息样本
危险的性行为(RSB)与药物滥用、外化问题和内化问题有关,以前的研究记录了RSB与这些其他感兴趣的因素之间显著的表型和遗传相关性。这些关系中潜在的性别差异此前也曾被研究过;作者之前的研究表明,女性的RSB与内化问题之间存在更强的相关性。目前的研究使用了科罗拉多双胞胎样本,并采用生物计量学方法来扩展先前的研究结果,以调查当外化问题被考虑在内时,RSB和内化问题之间的联系是否仍然存在,以及是否独特的遗传影响是这三个潜在因素之间联系的基础。我们还研究了三变量潜在模型中的性别差异是否重复了先前的证明。具体来说,我们假设RSB和内化问题之间的关联在女性中比在男性中更强,而在男性中RSB和外化问题之间的关联更强。最终结果待定。我们的结果可能对RSB作为一种结构的理解以及对公共卫生部门具有重要意义。有待进一步讨论。
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来源期刊
European Neuropsychopharmacology
European Neuropsychopharmacology 医学-精神病学
CiteScore
10.30
自引率
5.40%
发文量
730
审稿时长
41 days
期刊介绍: European Neuropsychopharmacology is the official publication of the European College of Neuropsychopharmacology (ECNP). In accordance with the mission of the College, the journal focuses on clinical and basic science contributions that advance our understanding of brain function and human behaviour and enable translation into improved treatments and enhanced public health impact in psychiatry. Recent years have been characterized by exciting advances in basic knowledge and available experimental techniques in neuroscience and genomics. However, clinical translation of these findings has not been as rapid. The journal aims to narrow this gap by promoting findings that are expected to have a major impact on both our understanding of the biological bases of mental disorders and the development and improvement of treatments, ideally paving the way for prevention and recovery.
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