Olga I. Vernaya, Alexey S. Shumilkin, Darya L. Karlova, Anna S. Shevchenko, Alina A. Makeeva, Andrey V. Shabatin, Alexandr M. Semenov, Tatiana I. Shabatina, Mikhai Ya. Melnikov
{"title":"CRYOFORMATION AND PROPERTIES OF DIOXIDIN/GELATIN SYSTEMS","authors":"Olga I. Vernaya, Alexey S. Shumilkin, Darya L. Karlova, Anna S. Shevchenko, Alina A. Makeeva, Andrey V. Shabatin, Alexandr M. Semenov, Tatiana I. Shabatina, Mikhai Ya. Melnikov","doi":"10.55959/msu0579-9384-2-2023-64-1-11-18","DOIUrl":null,"url":null,"abstract":"Cryoforming of gelatin systems with the antibacterial drug dioxidine was carried out. The paper considers the effect of system synthesis conditions (gelatin concentration in the precursor solution) on their structural characteristics, antibacterial activity, and drug release time. The composition and structure of the dioxidine/gelatin and dioxidine/hydrolyzed collagen systems were characterized by SEM, IR and UV spectroscopy. The disk diffusion method was used to determine the antibacterial activity of the obtained systems against E. coli and S. aureus.","PeriodicalId":23660,"journal":{"name":"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya","volume":"22 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55959/msu0579-9384-2-2023-64-1-11-18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cryoforming of gelatin systems with the antibacterial drug dioxidine was carried out. The paper considers the effect of system synthesis conditions (gelatin concentration in the precursor solution) on their structural characteristics, antibacterial activity, and drug release time. The composition and structure of the dioxidine/gelatin and dioxidine/hydrolyzed collagen systems were characterized by SEM, IR and UV spectroscopy. The disk diffusion method was used to determine the antibacterial activity of the obtained systems against E. coli and S. aureus.
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