Synergistic effect of continuous care and cephalosporin antimicrobials in managing pulmonary infections in acute stroke patients: A comprehensive study

IF 0.6 4区 医学 Q4 PHARMACOLOGY & PHARMACY Tropical Journal of Pharmaceutical Research Pub Date : 2023-11-06 DOI:10.4314/tjpr.v22i10.24
Lanqing W, Lirong Chen, Haiyou Liao
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Abstract

Purpose: To investigate potential benefits of continuous nursing combined with cephalosporin antibiotics in patients with acute cerebral infarction complicated by pulmonary infection. Methods: A total of 106 patients diagnosed with acute cerebral infarction complicated by pulmonary infection were selected for this study, and admitted to The Second Affiliated Hospital of Hainan Medical University, Haikou, China from June 2020 to June 2022. Patients were randomly divided into a control group (which received conventional care and cephalosporin antibiotics, n =53), and a study group managed with sustained nursing and cephalosporin antibiotics (n = 53). The study compared various clinical parameters between two groups before and after intervention, including time of symptom relief for fever, cough, and wet rales, as well as the National Institutes of Health Stroke Scale (NIHSS), FuglMeyer Assessment (FMA), Barthel Index (BI), Self-Perceived Burden Scale (SPBS), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and severity of pulmonary infection which was assessed by CURB 65 score. Results: Compared with control group, study group had a significantly shorter clinical symptom relief time after intervention (p < 0.05). After intervention, NIHSS, SPBS, SAS, SDS, APACHE II, and CURB 65 scores in study group were significantly lower, whereas FMA and BI scores were significantly higher before intervention (p < 0.05). Conclusion: Administration of nursing care and cephalosporin antibiotics reduces the time required for symptom relief, and improves neurological function in patients with acute cerebral infarction and pulmonary infections.
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持续护理和头孢菌素抗菌药物在治疗急性脑卒中患者肺部感染中的协同作用:一项综合研究
目的:探讨持续护理联合头孢菌素类抗生素对急性脑梗死合并肺部感染患者的潜在疗效。 方法:选取2020年6月至2022年6月海南医科大学第二附属医院收治的急性脑梗死合并肺部感染患者106例作为研究对象。将患者随机分为对照组(53例)和研究组(53例),对照组接受常规护理和头孢菌素类抗生素治疗。比较干预前后两组患者发热、咳嗽、湿疹症状缓解时间,以及美国国立卫生研究院卒中量表(NIHSS)、FuglMeyer量表(FMA)、Barthel指数(BI)、自我感知负担量表(SPBS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、急性生理与慢性健康评估II (APACHE II)评分。及肺部感染严重程度,以CURB 65评分评估。 结果:与对照组相比,研究组干预后临床症状缓解时间显著缩短(p <0.05)。干预后,实验组NIHSS、SPBS、SAS、SDS、APACHE II、CURB 65评分显著低于干预前,FMA、BI评分显著高于干预前(p <0.05)。& # x0D;结论:给予护理和头孢菌素类抗生素可缩短急性脑梗死合并肺部感染患者症状缓解所需时间,改善神经功能。
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来源期刊
CiteScore
1.00
自引率
33.30%
发文量
490
审稿时长
4-8 weeks
期刊介绍: We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.
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